BRD-K74777906_N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-3-methoxythiophene-2-sulfonamide_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

46 genes differentially expressed following the BRD-K74777906_N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-3-methoxythiophene-2-sulfonamide_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
BASP1 brain abundant, membrane attached signal protein 1
CD59 CD59 molecule, complement regulatory protein
CXCL12 chemokine (C-X-C motif) ligand 12
DUSP1 dual specificity phosphatase 1
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GPX3 glutathione peroxidase 3
HOXC6 homeobox C6
IRS2 insulin receptor substrate 2
LTBP3 latent transforming growth factor beta binding protein 3
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
PMP22 peripheral myelin protein 22
PPAP2B phosphatidic acid phosphatase type 2B
PRAME preferentially expressed antigen in melanoma
TCL1A T-cell leukemia/lymphoma 1A
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)

decreased expression

Symbol Name
ACSL3 acyl-CoA synthetase long-chain family member 3
ADGRL2 adhesion G protein-coupled receptor L2
AK4 adenylate kinase 4
ARMCX1 armadillo repeat containing, X-linked 1
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
C1ORF106 chromosome 1 open reading frame 106
CETN2 centrin, EF-hand protein, 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
ESR1 estrogen receptor 1
EZR ezrin
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
KRT23 keratin 23, type I
MB myoglobin
PDZK1 PDZ domain containing 1
PRR15L proline rich 15-like
PTN pleiotrophin
RGCC regulator of cell cycle
RPA3 replication protein A3, 14kDa
S100A14 S100 calcium binding protein A14
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
STK38L serine/threonine kinase 38 like
TMEM45A transmembrane protein 45A
TMSB15A thymosin beta 15a
TRA2A transformer 2 alpha homolog (Drosophila)
WFDC2 WAP four-disulfide core domain 2