BRD-K74690444_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

163 genes differentially expressed following the BRD-K74690444_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACPP acid phosphatase, prostate
AQP3 aquaporin 3 (Gill blood group)
ATF3 activating transcription factor 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
C1ORF54 chromosome 1 open reading frame 54
CD151 CD151 molecule (Raph blood group)
CD9 CD9 molecule
CDK19 cyclin-dependent kinase 19
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CLDN3 claudin 3
CLDN4 claudin 4
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM60A family with sequence similarity 60, member A
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXG1 forkhead box G1
GADD45B growth arrest and DNA-damage-inducible, beta
GCLC glutamate-cysteine ligase, catalytic subunit
GEM GTP binding protein overexpressed in skeletal muscle
HBEGF heparin-binding EGF-like growth factor
HBP1 HMG-box transcription factor 1
HCAR3 hydroxycarboxylic acid receptor 3
HILPDA hypoxia inducible lipid droplet-associated
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXB2 homeobox B2
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
JUNB jun B proto-oncogene
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
LAPTM5 lysosomal protein transmembrane 5
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN2A1 mannosidase, alpha, class 2A, member 1
MME membrane metallo-endopeptidase
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1X metallothionein 1X
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS16 regulator of G-protein signaling 16
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMAD3 SMAD family member 3
SULF1 sulfatase 1
TACSTD2 tumor-associated calcium signal transducer 2
TCF4 transcription factor 4
TGFB2 transforming growth factor, beta 2
TGM4 transglutaminase 4
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
VEGFA vascular endothelial growth factor A
YBX3 Y box binding protein 3
ZEB1 zinc finger E-box binding homeobox 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ASXL2 additional sex combs like transcriptional regulator 2
AURKA aurora kinase A
BRCA1 breast cancer 1, early onset
C1S complement component 1, s subcomponent
C6ORF62 chromosome 6 open reading frame 62
C7 complement component 7
CASP6 caspase 6, apoptosis-related cysteine peptidase
CCNF cyclin F
CIAPIN1 cytokine induced apoptosis inhibitor 1
COL16A1 collagen, type XVI, alpha 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL12 chemokine (C-X-C motif) ligand 12
CYBA cytochrome b-245, alpha polypeptide
DCN decorin
DLK1 delta-like 1 homolog (Drosophila)
DPYSL2 dihydropyrimidinase-like 2
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
FAM13B family with sequence similarity 13, member B
FAM178A family with sequence similarity 178, member A
FAM46A family with sequence similarity 46, member A
FBXO9 F-box protein 9
FLRT2 fibronectin leucine rich transmembrane protein 2
GAS1 growth arrest-specific 1
GCH1 GTP cyclohydrolase 1
GOLGA8A golgin A8 family, member A
GPX2 glutathione peroxidase 2
HEXIM1 hexamethylene bis-acetamide inducible 1
HLTF helicase-like transcription factor
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
IFI44 interferon-induced protein 44
ITM2A integral membrane protein 2A
KIAA0907 KIAA0907
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KYNU kynureninase
LRRC16A leucine rich repeat containing 16A
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MFAP5 microfibrillar associated protein 5
MKKS McKusick-Kaufman syndrome
NR2F2 nuclear receptor subfamily 2, group F, member 2
OLFM1 olfactomedin 1
OLFML1 olfactomedin-like 1
PLK1 polo-like kinase 1
PLXNC1 plexin C1
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTP4A2 protein tyrosine phosphatase type IVA, member 2
QPRT quinolinate phosphoribosyltransferase
RAP2A RAP2A, member of RAS oncogene family
RPIA ribose 5-phosphate isomerase A
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RSRP1 arginine/serine-rich protein 1
SAR1A secretion associated, Ras related GTPase 1A
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SPINK1 serine peptidase inhibitor, Kazal type 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SYNE1 spectrin repeat containing, nuclear envelope 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFRC transferrin receptor
TMEM47 transmembrane protein 47
TMEM97 transmembrane protein 97
TOB1 transducer of ERBB2, 1
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
TSPYL5 TSPY-like 5