BRD-K74514084_pazopanib_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

83 genes differentially expressed following the BRD-K74514084_pazopanib_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AIM1 absent in melanoma 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
CD24 CD24 molecule
CDH17 cadherin 17, LI cadherin (liver-intestine)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLCN3 chloride channel, voltage-sensitive 3
COL11A1 collagen, type XI, alpha 1
CRISP3 cysteine-rich secretory protein 3
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR3 early growth response 3
F13A1 coagulation factor XIII, A1 polypeptide
FAM60A family with sequence similarity 60, member A
FHL1 four and a half LIM domains 1
GATA3 GATA binding protein 3
GDF15 growth differentiation factor 15
HEATR1 HEAT repeat containing 1
HOXB6 homeobox B6
HSPA14 heat shock 70kDa protein 14
IGFBP7 insulin-like growth factor binding protein 7
IL17RB interleukin 17 receptor B
LGMN legumain
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LY75 lymphocyte antigen 75
MET MET proto-oncogene, receptor tyrosine kinase
MKRN1 makorin ring finger protein 1
NRIP1 nuclear receptor interacting protein 1
NT5E 5'-nucleotidase, ecto (CD73)
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4
OLFM4 olfactomedin 4
PALLD palladin, cytoskeletal associated protein
PEG10 paternally expressed 10
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAT plasminogen activator, tissue
PTK2 protein tyrosine kinase 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RPP38 ribonuclease P/MRP 38kDa subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SFRP4 secreted frizzled-related protein 4
SLC30A1 solute carrier family 30 (zinc transporter), member 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TRIM2 tripartite motif containing 2
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZBTB18 zinc finger and BTB domain containing 18
ZNF318 zinc finger protein 318

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ANXA6 annexin A6
APH1A APH1A gamma secretase subunit
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
COL3A1 collagen, type III, alpha 1
CSRP1 cysteine and glycine-rich protein 1
CTSZ cathepsin Z
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EIF5A eukaryotic translation initiation factor 5A
ESR1 estrogen receptor 1
GLOD4 glyoxalase domain containing 4
H1F0 H1 histone family, member 0
HEBP1 heme binding protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT23 keratin 23, type I
KRT6B keratin 6B, type II
NREP neuronal regeneration related protein
PMP22 peripheral myelin protein 22
PMVK phosphomevalonate kinase
PXMP2 peroxisomal membrane protein 2, 22kDa
RBP1 retinol binding protein 1, cellular
REEP5 receptor accessory protein 5
RPS4Y1 ribosomal protein S4, Y-linked 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SFN stratifin
SFTPB surfactant protein B
SPINK5 serine peptidase inhibitor, Kazal type 5
SPRR1A small proline-rich protein 1A
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta