BRD-K74514084_pazopanib_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

60 genes differentially expressed following the BRD-K74514084_pazopanib_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP12 A kinase (PRKA) anchor protein 12
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BPTF bromodomain PHD finger transcription factor
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DUSP6 dual specificity phosphatase 6
FABP6 fatty acid binding protein 6, ileal
GLRX glutaredoxin (thioltransferase)
HK1 hexokinase 1
IER3 immediate early response 3
ITGA6 integrin, alpha 6
KIAA0226L KIAA0226-like
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LUC7L3 LUC7-like 3 (S. cerevisiae)
MMP12 matrix metallopeptidase 12
PMEPA1 prostate transmembrane protein, androgen induced 1
RGS5 regulator of G-protein signaling 5
TCF4 transcription factor 4
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TOMM34 translocase of outer mitochondrial membrane 34
UBXN4 UBX domain protein 4
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta

decreased expression

Symbol Name
AK4 adenylate kinase 4
BAX BCL2-associated X protein
BEX1 brain expressed, X-linked 1
BST2 bone marrow stromal cell antigen 2
C2CD5 C2 calcium-dependent domain containing 5
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCL19 chemokine (C-C motif) ligand 19
CCL5 chemokine (C-C motif) ligand 5
CD69 CD69 molecule
CLU clusterin
CORO1A coronin, actin binding protein, 1A
CRYAB crystallin, alpha B
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
ERBB2 erb-b2 receptor tyrosine kinase 2
FUS FUS RNA binding protein
GPM6B glycoprotein M6B
GSTA4 glutathione S-transferase alpha 4
HIRA histone cell cycle regulator
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HP haptoglobin
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IL1R2 interleukin 1 receptor, type II
IL1RN interleukin 1 receptor antagonist
LAMP1 lysosomal-associated membrane protein 1
MB myoglobin
NCKAP1L NCK-associated protein 1-like
OBSL1 obscurin-like 1
PDIA3 protein disulfide isomerase family A, member 3
PEG3 paternally expressed 3
PTCH1 patched 1
RAD23B RAD23 homolog B (S. cerevisiae)
RBP1 retinol binding protein 1, cellular
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLPI secretory leukocyte peptidase inhibitor