BRD-K74402642_Chemistry 2804_RKO_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

179 genes differentially expressed following the BRD-K74402642_Chemistry 2804_RKO_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AREG amphiregulin
ATF3 activating transcription factor 3
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
BAG3 BCL2-associated athanogene 3
BCAS2 breast carcinoma amplified sequence 2
BEX1 brain expressed, X-linked 1
BEX4 brain expressed, X-linked 4
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C3ORF14 chromosome 3 open reading frame 14
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD52 CD52 molecule
CD9 CD9 molecule
CGRRF1 cell growth regulator with ring finger domain 1
CHIC2 cysteine-rich hydrophobic domain 2
CHMP4A charged multivesicular body protein 4A
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CSRP2 cysteine and glycine-rich protein 2
DDIT3 DNA-damage-inducible transcript 3
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNTT DNA nucleotidylexotransferase
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DUSP1 dual specificity phosphatase 1
EFHD1 EF-hand domain family, member D1
F11R F11 receptor
FN1 fibronectin 1
FOXO1 forkhead box O1
FST follistatin
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GTF2B general transcription factor IIB
H2BFS H2B histone family, member S (pseudogene)
HES1 hes family bHLH transcription factor 1
HIC2 hypermethylated in cancer 2
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HMOX1 heme oxygenase 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA2 heat shock 70kDa protein 2
HSPH1 heat shock 105kDa/110kDa protein 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGHM immunoglobulin heavy constant mu
IL7R interleukin 7 receptor
INHBA inhibin, beta A
IPO13 importin 13
JCHAIN joining chain of multimeric IgA and IgM
KLK5 kallikrein-related peptidase 5
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT14 keratin 14, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LAMP1 lysosomal-associated membrane protein 1
LAMP2 lysosomal-associated membrane protein 2
LST1 leukocyte specific transcript 1
MIR22HG MIR22 host gene
MOSPD1 motile sperm domain containing 1
MTF2 metal response element binding transcription factor 2
MX1 MX dynamin-like GTPase 1
MZB1 marginal zone B and B1 cell-specific protein
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
PEG10 paternally expressed 10
PELI1 pellino E3 ubiquitin protein ligase 1
PRKCI protein kinase C, iota
PROSC proline synthetase co-transcribed homolog (bacterial)
PRRC2C proline-rich coiled-coil 2C
PXDN peroxidasin
PXMP2 peroxisomal membrane protein 2, 22kDa
QKI QKI, KH domain containing, RNA binding
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFN stratifin
SFRP1 secreted frizzled-related protein 1
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC38A1 solute carrier family 38, member 1
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SPINK1 serine peptidase inhibitor, Kazal type 1
TAGLN transgelin
THBS1 thrombospondin 1
TPP1 tripeptidyl peptidase I
TPR translocated promoter region, nuclear basket protein
VCAN versican
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
YBX3 Y box binding protein 3
ZC3H15 zinc finger CCCH-type containing 15
ZNF165 zinc finger protein 165
ZNF292 zinc finger protein 292
ZNF331 zinc finger protein 331
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACLY ATP citrate lyase
AHNAK2 AHNAK nucleoprotein 2
ANKRD10 ankyrin repeat domain 10
ASS1 argininosuccinate synthase 1
ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
AUTS2 autism susceptibility candidate 2
BMI1 BMI1 proto-oncogene, polycomb ring finger
C2CD2 C2 calcium-dependent domain containing 2
CADPS2 Ca++-dependent secretion activator 2
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2
CAPNS1 calpain, small subunit 1
CCDC85B coiled-coil domain containing 85B
CCND1 cyclin D1
CFB complement factor B
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous)
DBN1 drebrin 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DST dystonin
EDF1 endothelial differentiation-related factor 1
EPN2 epsin 2
F12 coagulation factor XII (Hageman factor)
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FPGS folylpolyglutamate synthase
FXYD5 FXYD domain containing ion transport regulator 5
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRWD1 glutamate-rich WD repeat containing 1
HBB hemoglobin, beta
IGFBP6 insulin-like growth factor binding protein 6
KAZN kazrin, periplakin interacting protein
KDM5D lysine (K)-specific demethylase 5D
LDLRAP1 low density lipoprotein receptor adaptor protein 1
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIMA1 LIM domain and actin binding 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MLEC malectin
MSL1 male-specific lethal 1 homolog (Drosophila)
MTCL1 microtubule crosslinking factor 1
MXRA7 matrix-remodelling associated 7
NBN nibrin
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PLSCR3 phospholipid scramblase 3
PODXL podocalyxin-like
PRMT1 protein arginine methyltransferase 1
PTGES prostaglandin E synthase
RPS11 ribosomal protein S11
RRP1B ribosomal RNA processing 1B
S100A11 S100 calcium binding protein A11
SCD5 stearoyl-CoA desaturase 5
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SORD sorbitol dehydrogenase
SOX11 SRY (sex determining region Y)-box 11
STX1A syntaxin 1A (brain)
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TBC1D16 TBC1 domain family, member 16
TGM2 transglutaminase 2
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNS1 tensin 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN8 tetraspanin 8
TSPO translocator protein (18kDa)
TUBB tubulin, beta class I
UBE2S ubiquitin-conjugating enzyme E2S
WNT5A wingless-type MMTV integration site family, member 5A
ZNF512B zinc finger protein 512B