BRD-K73368362_BIX-02189_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

59 genes differentially expressed following the BRD-K73368362_BIX-02189_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ARMCX2 armadillo repeat containing, X-linked 2
BCL2 B-cell CLL/lymphoma 2
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
EPCAM epithelial cell adhesion molecule
FAM171A1 family with sequence similarity 171, member A1
FXYD2 FXYD domain containing ion transport regulator 2
HDGFRP3 hepatoma-derived growth factor, related protein 3
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HSPB8 heat shock 22kDa protein 8
L1CAM L1 cell adhesion molecule
LRRC16A leucine rich repeat containing 16A
MECOM MDS1 and EVI1 complex locus
NAP1L1 nucleosome assembly protein 1-like 1
PCP4 Purkinje cell protein 4
PENK proenkephalin
PLAC8 placenta-specific 8
PLCB4 phospholipase C, beta 4
PSPH phosphoserine phosphatase
PTHLH parathyroid hormone-like hormone
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIP6 thyroid hormone receptor interactor 6
TUSC3 tumor suppressor candidate 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AKAP12 A kinase (PRKA) anchor protein 12
APOC1 apolipoprotein C-I
CAST calpastatin
CCDC86 coiled-coil domain containing 86
CD99 CD99 molecule
CLU clusterin
CXCL8 chemokine (C-X-C motif) ligand 8
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENDOD1 endonuclease domain containing 1
FHL1 four and a half LIM domains 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IER5 immediate early response 5
IGFBP3 insulin-like growth factor binding protein 3
IL1R2 interleukin 1 receptor, type II
IQGAP2 IQ motif containing GTPase activating protein 2
LGALS3 lectin, galactoside-binding, soluble, 3
LOXL1 lysyl oxidase-like 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
PDLIM5 PDZ and LIM domain 5
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SPON2 spondin 2, extracellular matrix protein
TM4SF1 transmembrane 4 L six family member 1
TXNIP thioredoxin interacting protein
VDAC1 voltage-dependent anion channel 1