BRD-K73368362_BIX-02189_A375_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

103 genes differentially expressed following the BRD-K73368362_BIX-02189_A375_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASMTL acetylserotonin O-methyltransferase-like
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATM ATM serine/threonine kinase
BZW2 basic leucine zipper and W2 domains 2
C6ORF48 chromosome 6 open reading frame 48
CBS cystathionine-beta-synthase
CCND2 cyclin D2
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CSRP1 cysteine and glycine-rich protein 1
CYBA cytochrome b-245, alpha polypeptide
DEPTOR DEP domain containing MTOR-interacting protein
DLK1 delta-like 1 homolog (Drosophila)
EPRS glutamyl-prolyl-tRNA synthetase
FAM129A family with sequence similarity 129, member A
FKSG49 FKSG49
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GDF15 growth differentiation factor 15
GUSBP3 glucuronidase, beta pseudogene 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IARS isoleucyl-tRNA synthetase
ISG15 ISG15 ubiquitin-like modifier
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
LYZ lysozyme
MAOB monoamine oxidase B
MFAP5 microfibrillar associated protein 5
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NQO1 NAD(P)H dehydrogenase, quinone 1
NUPR1 nuclear protein, transcriptional regulator, 1
OBSL1 obscurin-like 1
OPHN1 oligophrenin 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE4DIP phosphodiesterase 4D interacting protein
PHGDH phosphoglycerate dehydrogenase
PHYH phytanoyl-CoA 2-hydroxylase
PROM1 prominin 1
PYCR1 pyrroline-5-carboxylate reductase 1
RAB29 RAB29, member RAS oncogene family
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RGS1 regulator of G-protein signaling 1
RPL37A ribosomal protein L37a
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SH3YL1 SH3 and SYLF domain containing 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC38A1 solute carrier family 38, member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOD2 superoxide dismutase 2, mitochondrial
SPP1 secreted phosphoprotein 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STC2 stanniocalcin 2
TCTN1 tectonic family member 1
THBS2 thrombospondin 2
TPD52L1 tumor protein D52-like 1
XAF1 XIAP associated factor 1
YPEL5 yippee-like 5 (Drosophila)
ZNF652 zinc finger protein 652

decreased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
BAD BCL2-associated agonist of cell death
CAV1 caveolin 1, caveolae protein, 22kDa
CLDN1 claudin 1
CLPTM1 cleft lip and palate associated transmembrane protein 1
COL4A1 collagen, type IV, alpha 1
COL4A5 collagen, type IV, alpha 5
CTGF connective tissue growth factor
CXADR coxsackie virus and adenovirus receptor
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DSC2 desmocollin 2
DST dystonin
EPHA3 EPH receptor A3
FLRT2 fibronectin leucine rich transmembrane protein 2
GJA1 gap junction protein, alpha 1, 43kDa
GPM6A glycoprotein M6A
H3F3B H3 histone, family 3B (H3.3B)
HNRNPM heterogeneous nuclear ribonucleoprotein M
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
KLF5 Kruppel-like factor 5 (intestinal)
KLK11 kallikrein-related peptidase 11
KRT1 keratin 1, type II
LPL lipoprotein lipase
LUM lumican
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MSN moesin
NID1 nidogen 1
OLFM4 olfactomedin 4
PODXL podocalyxin-like
RIN2 Ras and Rab interactor 2
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMPRSS2 transmembrane protease, serine 2
TUBB2A tubulin, beta 2A class IIa