BRD-K73319509_-666_NCIH508_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

206 genes differentially expressed following the BRD-K73319509_-666_NCIH508_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AEBP1 AE binding protein 1
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CARKD carbohydrate kinase domain containing
CCNB1 cyclin B1
CCND2 cyclin D2
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
COL1A1 collagen, type I, alpha 1
COL6A2 collagen, type VI, alpha 2
COLEC12 collectin sub-family member 12
DAPK1 death-associated protein kinase 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DSP desmoplakin
DSTN destrin (actin depolymerizing factor)
EFHD1 EF-hand domain family, member D1
EIF5A eukaryotic translation initiation factor 5A
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EZR ezrin
FBN2 fibrillin 2
FBXL7 F-box and leucine-rich repeat protein 7
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR3 fibroblast growth factor receptor 3
FN1 fibronectin 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GUSBP11 glucuronidase, beta pseudogene 11
GYPC glycophorin C (Gerbich blood group)
HIST1H2BG histone cluster 1, H2bg
HOMER3 homer scaffolding protein 3
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
LAMP5 lysosomal-associated membrane protein family, member 5
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS1 lectin, galactoside-binding, soluble, 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAN2A1 mannosidase, alpha, class 2A, member 1
MEIS2 Meis homeobox 2
MFSD10 major facilitator superfamily domain containing 10
MMP11 matrix metallopeptidase 11
MOXD1 monooxygenase, DBH-like 1
MYRF myelin regulatory factor
NCAM1 neural cell adhesion molecule 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRGN neurogranin (protein kinase C substrate, RC3)
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
PDLIM3 PDZ and LIM domain 3
PLAU plasminogen activator, urokinase
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PRTN3 proteinase 3
PXDN peroxidasin
RAB2A RAB2A, member RAS oncogene family
RBP1 retinol binding protein 1, cellular
RCAN2 regulator of calcineurin 2
RNH1 ribonuclease/angiogenin inhibitor 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SPON2 spondin 2, extracellular matrix protein
SULF1 sulfatase 1
TCF21 transcription factor 21
TDO2 tryptophan 2,3-dioxygenase
TEX10 testis expressed 10
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS2 thrombospondin 2
TMEM204 transmembrane protein 204
TMSB15A thymosin beta 15a
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TRO trophinin
VIM vimentin
VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae)
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADGRE5 adhesion G protein-coupled receptor E5
ADORA2B adenosine A2b receptor
AKR1C3 aldo-keto reductase family 1, member C3
ANXA3 annexin A3
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARPP19 cAMP-regulated phosphoprotein, 19kDa
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BIRC3 baculoviral IAP repeat containing 3
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BST2 bone marrow stromal cell antigen 2
CASP7 caspase 7, apoptosis-related cysteine peptidase
CAV2 caveolin 2
CCND3 cyclin D3
CD59 CD59 molecule, complement regulatory protein
CDK4 cyclin-dependent kinase 4
CDKN3 cyclin-dependent kinase inhibitor 3
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHPT1 choline phosphotransferase 1
CSNK1G3 casein kinase 1, gamma 3
CSTA cystatin A (stefin A)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL13 chemokine (C-X-C motif) ligand 13
CYB5A cytochrome b5 type A (microsomal)
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
CYTL1 cytokine-like 1
DARS aspartyl-tRNA synthetase
DLD dihydrolipoamide dehydrogenase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
EBP emopamil binding protein (sterol isomerase)
EIF5 eukaryotic translation initiation factor 5
EIF5B eukaryotic translation initiation factor 5B
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
F12 coagulation factor XII (Hageman factor)
FABP4 fatty acid binding protein 4, adipocyte
FAM13A family with sequence similarity 13, member A
FHL2 four and a half LIM domains 2
G0S2 G0/G1 switch 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GCH1 GTP cyclohydrolase 1
GDF15 growth differentiation factor 15
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GTF3A general transcription factor IIIA
HBB hemoglobin, beta
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HOXB6 homeobox B6
HPRT1 hypoxanthine phosphoribosyltransferase 1
KPNB1 karyopherin (importin) beta 1
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
LAMB3 laminin, beta 3
LPL lipoprotein lipase
LRRC16A leucine rich repeat containing 16A
LTF lactotransferrin
LY75 lymphocyte antigen 75
MARCKS myristoylated alanine-rich protein kinase C substrate
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
MMP7 matrix metallopeptidase 7
MOAP1 modulator of apoptosis 1
MPZL1 myelin protein zero-like 1
MRPL19 mitochondrial ribosomal protein L19
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NEFH neurofilament, heavy polypeptide
NOLC1 nucleolar and coiled-body phosphoprotein 1
NR1H3 nuclear receptor subfamily 1, group H, member 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUP62 nucleoporin 62kDa
PDZD8 PDZ domain containing 8
PELI1 pellino E3 ubiquitin protein ligase 1
PIP prolactin-induced protein
PLAC8 placenta-specific 8
PLAGL1 pleiomorphic adenoma gene-like 1
PPA1 pyrophosphatase (inorganic) 1
PPARG peroxisome proliferator-activated receptor gamma
PPIC peptidylprolyl isomerase C (cyclophilin C)
PPIG peptidylprolyl isomerase G (cyclophilin G)
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PROM1 prominin 1
PRPF4 pre-mRNA processing factor 4
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PTP4A2 protein tyrosine phosphatase type IVA, member 2
PTPN2 protein tyrosine phosphatase, non-receptor type 2
RAB40B RAB40B, member RAS oncogene family
RBKS ribokinase
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPIA ribose 5-phosphate isomerase A
RPL36AL ribosomal protein L36a-like
S100A2 S100 calcium binding protein A2
SAMD4A sterile alpha motif domain containing 4A
SC5D sterol-C5-desaturase
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SEH1L SEH1-like (S. cerevisiae)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SFN stratifin
SPAG1 sperm associated antigen 1
SPRY2 sprouty homolog 2 (Drosophila)
SYBU syntabulin (syntaxin-interacting)
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIMP4 TIMP metallopeptidase inhibitor 4
TM4SF1 transmembrane 4 L six family member 1
TMEM126B transmembrane protein 126B
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNIP1 TNFAIP3 interacting protein 1
TSPAN3 tetraspanin 3
TSPAN31 tetraspanin 31
TSPAN8 tetraspanin 8
TUBB2B tubulin, beta 2B class IIb
UBE3C ubiquitin protein ligase E3C
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WDR3 WD repeat domain 3
WDR43 WD repeat domain 43
WSB2 WD repeat and SOCS box containing 2
XBP1 X-box binding protein 1