BRD-K73125384_Acetic acid N-(2-methoxy-phenyl)-N-[3-oxo-3H-benzo[b]thiophen-(2Z)-ylidene]-hydrazide_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

42 genes differentially expressed following the BRD-K73125384_Acetic acid N-(2-methoxy-phenyl)-N-[3-oxo-3H-benzo[b]thiophen-(2Z)-ylidene]-hydrazide_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C3 aldo-keto reductase family 1, member C3
ALOX5 arachidonate 5-lipoxygenase
BAMBI BMP and activin membrane-bound inhibitor
CBR3 carbonyl reductase 3
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DUSP3 dual specificity phosphatase 3
EPCAM epithelial cell adhesion molecule
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
GCLM glutamate-cysteine ligase, modifier subunit
HMOX1 heme oxygenase 1
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
MYB v-myb avian myeloblastosis viral oncogene homolog
NQO1 NAD(P)H dehydrogenase, quinone 1
PLEKHJ1 pleckstrin homology domain containing, family J member 1
RAP1GAP RAP1 GTPase activating protein
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
TCL1A T-cell leukemia/lymphoma 1A
TFF3 trefoil factor 3 (intestinal)
TSPAN1 tetraspanin 1
TXNRD1 thioredoxin reductase 1

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
AQP3 aquaporin 3 (Gill blood group)
CADM1 cell adhesion molecule 1
CXCL11 chemokine (C-X-C motif) ligand 11
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FABP7 fatty acid binding protein 7, brain
GLRX glutaredoxin (thioltransferase)
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
LGALS1 lectin, galactoside-binding, soluble, 1
MAP7 microtubule-associated protein 7
MDFIC MyoD family inhibitor domain containing
PDE4D phosphodiesterase 4D, cAMP-specific
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SST somatostatin
TARP TCR gamma alternate reading frame protein
TNNC1 troponin C type 1 (slow)
TYMS thymidylate synthetase
TYRP1 tyrosinase-related protein 1