BRD-K73125384_Acetic acid N-(2-methoxy-phenyl)-N-[3-oxo-3H-benzo[b]thiophen-(2Z)-ylidene]-hydrazide_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

131 genes differentially expressed following the BRD-K73125384_Acetic acid N-(2-methoxy-phenyl)-N-[3-oxo-3H-benzo[b]thiophen-(2Z)-ylidene]-hydrazide_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANXA1 annexin A1
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BAG2 BCL2-associated athanogene 2
C5ORF30 chromosome 5 open reading frame 30
CBR3 carbonyl reductase 3
CBS cystathionine-beta-synthase
CD302 CD302 molecule
CES1 carboxylesterase 1
CLU clusterin
CPT1A carnitine palmitoyltransferase 1A (liver)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
DDIT4 DNA-damage-inducible transcript 4
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FCGBP Fc fragment of IgG binding protein
FTH1 ferritin, heavy polypeptide 1
FZD7 frizzled class receptor 7
G6PD glucose-6-phosphate dehydrogenase
GAA glucosidase, alpha; acid
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPM6B glycoprotein M6B
GPX2 glutathione peroxidase 2
GSTM1 glutathione S-transferase mu 1
GSTM2 glutathione S-transferase mu 2 (muscle)
GSTM3 glutathione S-transferase mu 3 (brain)
GULP1 GULP, engulfment adaptor PTB domain containing 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HMOX1 heme oxygenase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
KYNU kynureninase
LY75 lymphocyte antigen 75
MAP1B microtubule-associated protein 1B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEGF9 multiple EGF-like-domains 9
MN1 meningioma (disrupted in balanced translocation) 1
MVP major vault protein
NAMPT nicotinamide phosphoribosyltransferase
NEFH neurofilament, heavy polypeptide
NID1 nidogen 1
NLGN4X neuroligin 4, X-linked
NQO1 NAD(P)H dehydrogenase, quinone 1
NRCAM neuronal cell adhesion molecule
PDGFD platelet derived growth factor D
PGD phosphogluconate dehydrogenase
PIR pirin (iron-binding nuclear protein)
POPDC3 popeye domain containing 3
RAP1GAP RAP1 GTPase activating protein
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
SLC35G2 solute carrier family 35, member G2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SQSTM1 sequestosome 1
TAC1 tachykinin, precursor 1
TALDO1 transaldolase 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFBI transforming growth factor, beta-induced, 68kDa
THBD thrombomodulin
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKT transketolase
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TSPO translocator protein (18kDa)
TUBB2B tubulin, beta 2B class IIb
TXN thioredoxin
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZIC1 Zic family member 1

decreased expression

Symbol Name
ADCY1 adenylate cyclase 1 (brain)
AIM1 absent in melanoma 1
ANKRD36B ankyrin repeat domain 36B
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BANK1 B-cell scaffold protein with ankyrin repeats 1
CD24 CD24 molecule
COL4A5 collagen, type IV, alpha 5
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EVL Enah/Vasp-like
EZR ezrin
FHL2 four and a half LIM domains 2
GNAS GNAS complex locus
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IGLV2-23 immunoglobulin lambda variable 2-23
IL13RA1 interleukin 13 receptor, alpha 1
KDM4B lysine (K)-specific demethylase 4B
KRT15 keratin 15, type I
LEF1 lymphoid enhancer-binding factor 1
LUM lumican
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
PDLIM5 PDZ and LIM domain 5
POSTN periostin, osteoblast specific factor
PRSS23 protease, serine, 23
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEC14L1 SEC14-like 1 (S. cerevisiae)
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SNX10 sorting nexin 10
SON SON DNA binding protein
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPON1 spondin 1, extracellular matrix protein
TGFBR3 transforming growth factor, beta receptor III
TM7SF2 transmembrane 7 superfamily member 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPD52 tumor protein D52
TSPAN13 tetraspanin 13
YME1L1 YME1-like 1 ATPase