BRD-K72895815_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

150 genes differentially expressed following the BRD-K72895815_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AIM2 absent in melanoma 2
AQP3 aquaporin 3 (Gill blood group)
ATG101 autophagy related 101
BACE2 beta-site APP-cleaving enzyme 2
BAG3 BCL2-associated athanogene 3
BCL6 B-cell CLL/lymphoma 6
BTG1 B-cell translocation gene 1, anti-proliferative
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD58 CD58 molecule
CELF2 CUGBP, Elav-like family member 2
CGRRF1 cell growth regulator with ring finger domain 1
CHIC2 cysteine-rich hydrophobic domain 2
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EPHA2 EPH receptor A2
FOSL1 FOS-like antigen 1
GADD45B growth arrest and DNA-damage-inducible, beta
HACD1 3-hydroxyacyl-CoA dehydratase 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDS iduronate 2-sulfatase
IFRD1 interferon-related developmental regulator 1
IGHM immunoglobulin heavy constant mu
IGHMBP2 immunoglobulin mu binding protein 2
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
ISG20 interferon stimulated exonuclease gene 20kDa
JUNB jun B proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LDLR low density lipoprotein receptor
LOX lysyl oxidase
NNMT nicotinamide N-methyltransferase
PDGFA platelet-derived growth factor alpha polypeptide
PFKP phosphofructokinase, platelet
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK2 polo-like kinase 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRR7 proline rich 7 (synaptic)
PTX3 pentraxin 3, long
RALGDS ral guanine nucleotide dissociation stimulator
RGS2 regulator of G-protein signaling 2
S100A2 S100 calcium binding protein A2
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNIP1 TNFAIP3 interacting protein 1
UBE2S ubiquitin-conjugating enzyme E2S
UGCG UDP-glucose ceramide glucosyltransferase
ZMYM2 zinc finger, MYM-type 2

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACTA2 actin, alpha 2, smooth muscle, aorta
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHCY adenosylhomocysteinase
AHSG alpha-2-HS-glycoprotein
ALCAM activated leukocyte cell adhesion molecule
ANXA4 annexin A4
APOC3 apolipoprotein C-III
APOH apolipoprotein H (beta-2-glycoprotein I)
APOLD1 apolipoprotein L domain containing 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARMT1 acidic residue methyltransferase 1
BRCA1 breast cancer 1, early onset
C2CD5 C2 calcium-dependent domain containing 5
CA2 carbonic anhydrase II
CALD1 caldesmon 1
CAST calpastatin
CD24 CD24 molecule
CD93 CD93 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
DMD dystrophin
DPYSL2 dihydropyrimidinase-like 2
EDNRA endothelin receptor type A
FBXO21 F-box protein 21
FGA fibrinogen alpha chain
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOLR1 folate receptor 1 (adult)
FSTL1 follistatin-like 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
IQGAP1 IQ motif containing GTPase activating protein 1
ISYNA1 inositol-3-phosphate synthase 1
ITGA6 integrin, alpha 6
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KCTD12 potassium channel tetramerization domain containing 12
LAMB1 laminin, beta 1
LEFTY1 left-right determination factor 1
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LUC7L3 LUC7-like 3 (S. cerevisiae)
MARCKS myristoylated alanine-rich protein kinase C substrate
MMD monocyte to macrophage differentiation-associated
MSN moesin
MXRA5 matrix-remodelling associated 5
MYOF myoferlin
NDN necdin, melanoma antigen (MAGE) family member
NDRG3 NDRG family member 3
PCP4 Purkinje cell protein 4
PDE4A phosphodiesterase 4A, cAMP-specific
PEG3 paternally expressed 3
PNMAL1 paraneoplastic Ma antigen family-like 1
PODXL podocalyxin-like
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPAP2B phosphatidic acid phosphatase type 2B
PROM1 prominin 1
PTCH1 patched 1
RGS5 regulator of G-protein signaling 5
SERINC5 serine incorporator 5
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SOSTDC1 sclerostin domain containing 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
STXBP2 syntaxin binding protein 2
TF transferrin
TMEM204 transmembrane protein 204
TMEM97 transmembrane protein 97
TNS1 tensin 1
TOX3 TOX high mobility group box family member 3
TRAP1 TNF receptor-associated protein 1
TSPAN12 tetraspanin 12
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VAT1 vesicle amine transport 1
VWF von Willebrand factor