BRD-K72883421_4-(5-(3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)benzoic acid WFM1.19E_HT29_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

76 genes differentially expressed following the BRD-K72883421_4-(5-(3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)benzoic acid WFM1.19E_HT29_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
AQP9 aquaporin 9
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX1 brain expressed, X-linked 1
CDK6 cyclin-dependent kinase 6
CES1 carboxylesterase 1
CXCL12 chemokine (C-X-C motif) ligand 12
DHRS2 dehydrogenase/reductase (SDR family) member 2
DSP desmoplakin
ECM1 extracellular matrix protein 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FUS FUS RNA binding protein
GAS1 growth arrest-specific 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLUL glutamate-ammonia ligase
H1F0 H1 histone family, member 0
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
KRT4 keratin 4, type II
NRN1 neuritin 1
PDIA3 protein disulfide isomerase family A, member 3
PDLIM2 PDZ and LIM domain 2 (mystique)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAC8 placenta-specific 8
PLAGL1 pleiomorphic adenoma gene-like 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RGS2 regulator of G-protein signaling 2
S100A8 S100 calcium binding protein A8
SCGB2A2 secretoglobin, family 2A, member 2
SCML1 sex comb on midleg-like 1 (Drosophila)
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SORBS3 sorbin and SH3 domain containing 3
SRPX sushi-repeat containing protein, X-linked
TCFL5 transcription factor-like 5 (basic helix-loop-helix)

decreased expression

Symbol Name
ADCY2 adenylate cyclase 2 (brain)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP9A ATPase, class II, type 9A
CCDC86 coiled-coil domain containing 86
CD24 CD24 molecule
CKS2 CDC28 protein kinase regulatory subunit 2
CLU clusterin
CRYAB crystallin, alpha B
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL14 chemokine (C-X-C motif) ligand 14
EIF5A eukaryotic translation initiation factor 5A
EIF5B eukaryotic translation initiation factor 5B
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EZR ezrin
FTH1 ferritin, heavy polypeptide 1
GJA1 gap junction protein, alpha 1, 43kDa
GPX3 glutathione peroxidase 3
GULP1 GULP, engulfment adaptor PTB domain containing 1
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
KRT20 keratin 20, type I
LIMCH1 LIM and calponin homology domains 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MYLK myosin light chain kinase
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
PFDN4 prefoldin subunit 4
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SOSTDC1 sclerostin domain containing 1
SST somatostatin
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TCTA T-cell leukemia translocation altered
TFPI2 tissue factor pathway inhibitor 2
TMEM100 transmembrane protein 100
TMEM131 transmembrane protein 131
TXNDC9 thioredoxin domain containing 9
VAMP8 vesicle-associated membrane protein 8