BRD-K72636697_QL-X-138_PC3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

117 genes differentially expressed following the BRD-K72636697_QL-X-138_PC3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIRF adipogenesis regulatory factor
AKAP9 A kinase (PRKA) anchor protein 9
AMIGO2 adhesion molecule with Ig-like domain 2
AMOTL2 angiomotin like 2
APOD apolipoprotein D
BASP1 brain abundant, membrane attached signal protein 1
BCAM basal cell adhesion molecule (Lutheran blood group)
BHLHE41 basic helix-loop-helix family, member e41
BSG basigin (Ok blood group)
C10ORF10 chromosome 10 open reading frame 10
CD59 CD59 molecule, complement regulatory protein
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFD complement factor D (adipsin)
CHMP4A charged multivesicular body protein 4A
CRIP1 cysteine-rich protein 1 (intestinal)
CTGF connective tissue growth factor
CYBRD1 cytochrome b reductase 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
DUSP4 dual specificity phosphatase 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EPAS1 endothelial PAS domain protein 1
ERBB2 erb-b2 receptor tyrosine kinase 2
F13A1 coagulation factor XIII, A1 polypeptide
FABP4 fatty acid binding protein 4, adipocyte
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FGFR2 fibroblast growth factor receptor 2
GATAD1 GATA zinc finger domain containing 1
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8B golgin A8 family, member B
GSN gelsolin
HDAC5 histone deacetylase 5
HMGA2 high mobility group AT-hook 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT8 keratin 8, type II
LAMB2 laminin, beta 2 (laminin S)
MARCKS myristoylated alanine-rich protein kinase C substrate
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PILRB paired immunoglobin-like type 2 receptor beta
PRSS23 protease, serine, 23
PTCH1 patched 1
RBKS ribokinase
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100P S100 calcium binding protein P
SMAD3 SMAD family member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SSR4 signal sequence receptor, delta
TARBP1 TAR (HIV-1) RNA binding protein 1
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
TM4SF1 transmembrane 4 L six family member 1
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
AK4 adenylate kinase 4
ARPC5L actin related protein 2/3 complex, subunit 5-like
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C20ORF24 chromosome 20 open reading frame 24
CA12 carbonic anhydrase XII
CCL20 chemokine (C-C motif) ligand 20
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
COL1A2 collagen, type I, alpha 2
CSTA cystatin A (stefin A)
CXCL8 chemokine (C-X-C motif) ligand 8
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
FADS1 fatty acid desaturase 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GAL galanin/GMAP prepropeptide
GBP1 guanylate binding protein 1, interferon-inducible
GCH1 GTP cyclohydrolase 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GSTM3 glutathione S-transferase mu 3 (brain)
HSPA14 heat shock 70kDa protein 14
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP5 insulin-like growth factor binding protein 5
IL13RA2 interleukin 13 receptor, alpha 2
IL1RN interleukin 1 receptor antagonist
INSIG1 insulin induced gene 1
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
MCM10 minichromosome maintenance complex component 10
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP12 matrix metallopeptidase 12
MT1M metallothionein 1M
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NEFL neurofilament, light polypeptide
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PGK1 phosphoglycerate kinase 1
PI3 peptidase inhibitor 3, skin-derived
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
REEP1 receptor accessory protein 1
SDC2 syndecan 2
SORD sorbitol dehydrogenase
TDO2 tryptophan 2,3-dioxygenase
TFRC transferrin receptor
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRAPPC3 trafficking protein particle complex 3
TUBG1 tubulin, gamma 1