BRD-K72636697_QL-X-138_LNCAP_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

187 genes differentially expressed following the BRD-K72636697_QL-X-138_LNCAP_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ARID5B AT rich interactive domain 5B (MRF1-like)
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASCL1 achaete-scute family bHLH transcription factor 1
BCAM basal cell adhesion molecule (Lutheran blood group)
BPTF bromodomain PHD finger transcription factor
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CCNG2 cyclin G2
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CLU clusterin
COL4A5 collagen, type IV, alpha 5
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CST3 cystatin C
DUSP4 dual specificity phosphatase 4
EFNA1 ephrin-A1
EGFL6 EGF-like-domain, multiple 6
ERBB2 erb-b2 receptor tyrosine kinase 2
ESR1 estrogen receptor 1
FAM46A family with sequence similarity 46, member A
FNDC3B fibronectin type III domain containing 3B
FXR1 fragile X mental retardation, autosomal homolog 1
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GOLGA8H golgin A8 family, member H
GOLGB1 golgin B1
GPX3 glutathione peroxidase 3
HIST3H2A histone cluster 3, H2a
HMBOX1 homeobox containing 1
ICAM1 intercellular adhesion molecule 1
JUP junction plakoglobin
KAT6B K(lysine) acetyltransferase 6B
KDM3A lysine (K)-specific demethylase 3A
KRT19 keratin 19, type I
LAMC2 laminin, gamma 2
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LUC7L3 LUC7-like 3 (S. cerevisiae)
LXN latexin
MARCKS myristoylated alanine-rich protein kinase C substrate
MT1F metallothionein 1F
MTSS1 metastasis suppressor 1
NOTCH2NL notch 2 N-terminal like
OFD1 oral-facial-digital syndrome 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDGFD platelet derived growth factor D
RPS11 ribosomal protein S11
SEPP1 selenoprotein P, plasma, 1
SFN stratifin
SFTPA2 surfactant protein A2
SIDT2 SID1 transmembrane family, member 2
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SMAD3 SMAD family member 3
SMYD2 SET and MYND domain containing 2
SNX11 sorting nexin 11
SPATA20 spermatogenesis associated 20
SPINT2 serine peptidase inhibitor, Kunitz type, 2
TFPI2 tissue factor pathway inhibitor 2
TGFBR3 transforming growth factor, beta receptor III
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TUSC3 tumor suppressor candidate 3
TXNIP thioredoxin interacting protein
WSB1 WD repeat and SOCS box containing 1
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACOT7 acyl-CoA thioesterase 7
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ASF1B anti-silencing function 1B histone chaperone
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
CA2 carbonic anhydrase II
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCNA2 cyclin A2
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK2 cyclin-dependent kinase 2
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK1 checkpoint kinase 1
CLIC4 chloride intracellular channel 4
CXCL10 chemokine (C-X-C motif) ligand 10
DCK deoxycytidine kinase
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DGKZ diacylglycerol kinase, zeta
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCI Fanconi anemia, complementation group I
FCGBP Fc fragment of IgG binding protein
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
FXYD5 FXYD domain containing ion transport regulator 5
GARS glycyl-tRNA synthetase
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS4 GINS complex subunit 4 (Sld5 homolog)
GMNN geminin, DNA replication inhibitor
GTSE1 G-2 and S-phase expressed 1
HMGB1 high mobility group box 1
HOXC10 homeobox C10
HSPA2 heat shock 70kDa protein 2
IARS isoleucyl-tRNA synthetase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGHM immunoglobulin heavy constant mu
INSIG1 insulin induced gene 1
KIAA0101 KIAA0101
KIF14 kinesin family member 14
LAPTM4B lysosomal protein transmembrane 4 beta
LMNB2 lamin B2
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MMP9 matrix metallopeptidase 9
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NFE2L3 nuclear factor, erythroid 2-like 3
NQO1 NAD(P)H dehydrogenase, quinone 1
ORC6 origin recognition complex, subunit 6
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCNA proliferating cell nuclear antigen
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PHGDH phosphoglycerate dehydrogenase
PLK4 polo-like kinase 4
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
RAD51AP1 RAD51 associated protein 1
RANBP1 RAN binding protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS1 regulator of G-protein signaling 1
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100P S100 calcium binding protein P
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPC25 SPC25, NDC80 kinetochore complex component
STMN1 stathmin 1
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TMEM194A transmembrane protein 194A
TMEM5 transmembrane protein 5
TMEM97 transmembrane protein 97
TRIB3 tribbles pseudokinase 3
TRIP13 thyroid hormone receptor interactor 13
TSPAN8 tetraspanin 8
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
VRK1 vaccinia related kinase 1
ZWILCH zwilch kinetochore protein
ZWINT ZW10 interacting kinetochore protein