BRD-K72636697_QL-X-138_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

299 genes differentially expressed following the BRD-K72636697_QL-X-138_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGTR1 angiotensin II receptor, type 1
ANKRD36B ankyrin repeat domain 36B
BPTF bromodomain PHD finger transcription factor
C19ORF54 chromosome 19 open reading frame 54
C6ORF48 chromosome 6 open reading frame 48
CASC3 cancer susceptibility candidate 3
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD44 CD44 molecule (Indian blood group)
CDC45 cell division cycle 45
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHMP4A charged multivesicular body protein 4A
COG4 component of oligomeric golgi complex 4
CXADR coxsackie virus and adenovirus receptor
DCLK1 doublecortin-like kinase 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DEK DEK proto-oncogene
DUSP6 dual specificity phosphatase 6
E2F2 E2F transcription factor 2
EGFR epidermal growth factor receptor
ESD esterase D
FANCL Fanconi anemia, complementation group L
FOXG1 forkhead box G1
FXR1 fragile X mental retardation, autosomal homolog 1
GALC galactosylceramidase
GLTSCR2 glioma tumor suppressor candidate region gene 2
GLUL glutamate-ammonia ligase
GOLGA8H golgin A8 family, member H
GTPBP8 GTP-binding protein 8 (putative)
HAUS4 HAUS augmin-like complex, subunit 4
HEBP1 heme binding protein 1
HELLS helicase, lymphoid-specific
HIST1H4C histone cluster 1, H4c
HIST3H2A histone cluster 3, H2a
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGHMBP2 immunoglobulin mu binding protein 2
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRS2 insulin receptor substrate 2
ITGB4 integrin, beta 4
ITM2A integral membrane protein 2A
KAT6A K(lysine) acetyltransferase 6A
KDM5A lysine (K)-specific demethylase 5A
KLHDC2 kelch domain containing 2
LETMD1 LETM1 domain containing 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LOC100272216 uncharacterized LOC100272216
MBNL2 muscleblind-like splicing regulator 2
MED13 mediator complex subunit 13
MUM1 melanoma associated antigen (mutated) 1
N4BP2L1 NEDD4 binding protein 2-like 1
N4BP2L2 NEDD4 binding protein 2-like 2
NBR1 neighbor of BRCA1 gene 1
NKTR natural killer cell triggering receptor
NUSAP1 nucleolar and spindle associated protein 1
OXA1L oxidase (cytochrome c) assembly 1-like
PAN2 PAN2 poly(A) specific ribonuclease subunit
PARP2 poly (ADP-ribose) polymerase 2
PARP6 poly (ADP-ribose) polymerase family, member 6
PAX6 paired box 6
PCM1 pericentriolar material 1
PHIP pleckstrin homology domain interacting protein
PKN2 protein kinase N2
PNISR PNN-interacting serine/arginine-rich protein
POSTN periostin, osteoblast specific factor
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RAD50 RAD50 homolog (S. cerevisiae)
RB1CC1 RB1-inducible coiled-coil 1
RNASEH2A ribonuclease H2, subunit A
RNF115 ring finger protein 115
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15
SMC3 structural maintenance of chromosomes 3
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNX1 sorting nexin 1
SOX4 SRY (sex determining region Y)-box 4
SPAG7 sperm associated antigen 7
SSFA2 sperm specific antigen 2
STAG2 stromal antigen 2
STOM stomatin
SYNE2 spectrin repeat containing, nuclear envelope 2
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TNPO1 transportin 1
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TPR translocated promoter region, nuclear basket protein
TRD T cell receptor delta locus
TRIP6 thyroid hormone receptor interactor 6
USP1 ubiquitin specific peptidase 1
VWA8 von Willebrand factor A domain containing 8
WDR19 WD repeat domain 19
XIST X inactive specific transcript (non-protein coding)
ZC3H14 zinc finger CCCH-type containing 14
ZIC1 Zic family member 1
ZNF271P zinc finger protein 271, pseudogene
ZNF638 zinc finger protein 638
ZNF83 zinc finger protein 83

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABHD6 abhydrolase domain containing 6
ACAT2 acetyl-CoA acetyltransferase 2
ACKR3 atypical chemokine receptor 3
ACPP acid phosphatase, prostate
ACSL3 acyl-CoA synthetase long-chain family member 3
ADAM19 ADAM metallopeptidase domain 19
ADGRG1 adhesion G protein-coupled receptor G1
ADI1 acireductone dioxygenase 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDOA aldolase A, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ANXA6 annexin A6
AQP3 aquaporin 3 (Gill blood group)
ARF4 ADP-ribosylation factor 4
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPH aspartate beta-hydroxylase
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BIRC3 baculoviral IAP repeat containing 3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CALR calreticulin
CALU calumenin
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCR7 chemokine (C-C motif) receptor 7
CD24 CD24 molecule
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CKAP4 cytoskeleton-associated protein 4
CLIC5 chloride intracellular channel 5
CNN3 calponin 3, acidic
COL4A5 collagen, type IV, alpha 5
COL5A1 collagen, type V, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CRELD2 cysteine-rich with EGF-like domains 2
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CTSC cathepsin C
CTSZ cathepsin Z
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL8 chemokine (C-X-C motif) ligand 8
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DEPTOR DEP domain containing MTOR-interacting protein
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
DOCK10 dedicator of cytokinesis 10
EAF2 ELL associated factor 2
EBP emopamil binding protein (sterol isomerase)
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EDN1 endothelin 1
EGF epidermal growth factor
EGLN3 egl-9 family hypoxia-inducible factor 3
EMP3 epithelial membrane protein 3
ENO1 enolase 1, (alpha)
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FADS3 fatty acid desaturase 3
FBN1 fibrillin 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FKBP11 FK506 binding protein 11, 19 kDa
FN1 fibronectin 1
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
G6PD glucose-6-phosphate dehydrogenase
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GATA2 GATA binding protein 2
GDE1 glycerophosphodiester phosphodiesterase 1
GLIPR1 GLI pathogenesis-related 1
GOLT1B golgi transport 1B
GPX3 glutathione peroxidase 3
GSTA1 glutathione S-transferase alpha 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HHEX hematopoietically expressed homeobox
HILPDA hypoxia inducible lipid droplet-associated
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOMER2 homer scaffolding protein 2
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPB8 heat shock 22kDa protein 8
HYOU1 hypoxia up-regulated 1
ICAM1 intercellular adhesion molecule 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGSF3 immunoglobulin superfamily, member 3
IL32 interleukin 32
INSIG1 insulin induced gene 1
JCHAIN joining chain of multimeric IgA and IgM
KCNK3 potassium channel, two pore domain subfamily K, member 3
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KLF4 Kruppel-like factor 4 (gut)
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT8 keratin 8, type II
LDLR low density lipoprotein receptor
LIPA lipase A, lysosomal acid, cholesterol esterase
LOXL1 lysyl oxidase-like 1
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MAL mal, T-cell differentiation protein
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSMB microseminoprotein, beta-
MSMO1 methylsterol monooxygenase 1
MYCBP MYC binding protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NDN necdin, melanoma antigen (MAGE) family member
NFE2L3 nuclear factor, erythroid 2-like 3
NKX3-1 NK3 homeobox 1
NLRP2 NLR family, pyrin domain containing 2
NSDHL NAD(P) dependent steroid dehydrogenase-like
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
P3H2 prolyl 3-hydroxylase 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAX8 paired box 8
PDIA3 protein disulfide isomerase family A, member 3
PDIA4 protein disulfide isomerase family A, member 4
PDIA6 protein disulfide isomerase family A, member 6
PEA15 phosphoprotein enriched in astrocytes 15
PEG10 paternally expressed 10
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGC progastricsin (pepsinogen C)
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PHGDH phosphoglycerate dehydrogenase
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIR pirin (iron-binding nuclear protein)
PITX1 paired-like homeodomain 1
PKM pyruvate kinase, muscle
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PTBP3 polypyrimidine tract binding protein 3
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PYCR1 pyrroline-5-carboxylate reductase 1
QPRT quinolinate phosphoribosyltransferase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RIN2 Ras and Rab interactor 2
RRBP1 ribosome binding protein 1
RSU1 Ras suppressor protein 1
SC5D sterol-C5-desaturase
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC2 syndecan 2
SDC4 syndecan 4
SEC24A SEC24 family member A
SEC24D SEC24 family member D
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SESN1 sestrin 1
SH2B3 SH2B adaptor protein 3
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC43A3 solute carrier family 43, member 3
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SOAT1 sterol O-acyltransferase 1
SORD sorbitol dehydrogenase
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SQLE squalene epoxidase
SRGN serglycin
SSR1 signal sequence receptor, alpha
SST somatostatin
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SUB1 SUB1 homolog (S. cerevisiae)
SYNPO synaptopodin
TACSTD2 tumor-associated calcium signal transducer 2
TARP TCR gamma alternate reading frame protein
TARS threonyl-tRNA synthetase
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCF4 transcription factor 4
TMEM100 transmembrane protein 100
TMEM2 transmembrane protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNS1 tensin 1
TPST2 tyrosylprotein sulfotransferase 2
UXS1 UDP-glucuronate decarboxylase 1
VAMP8 vesicle-associated membrane protein 8
VCAM1 vascular cell adhesion molecule 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WDR61 WD repeat domain 61
XBP1 X-box binding protein 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta