BRD-K72636697_QL-X-138_A549_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

286 genes differentially expressed following the BRD-K72636697_QL-X-138_A549_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACBD3 acyl-CoA binding domain containing 3
ADM adrenomedullin
AKT3 v-akt murine thymoma viral oncogene homolog 3
AMOTL2 angiomotin like 2
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
AREG amphiregulin
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF1 activating transcription factor 1
ATF3 activating transcription factor 3
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BIRC2 baculoviral IAP repeat containing 2
BTG1 B-cell translocation gene 1, anti-proliferative
CA2 carbonic anhydrase II
CASC3 cancer susceptibility candidate 3
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDK19 cyclin-dependent kinase 19
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CELF2 CUGBP, Elav-like family member 2
CFLAR CASP8 and FADD-like apoptosis regulator
CHIC2 cysteine-rich hydrophobic domain 2
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLEC2B C-type lectin domain family 2, member B
CREBBP CREB binding protein
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CTGF connective tissue growth factor
CUL5 cullin 5
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYR61 cysteine-rich, angiogenic inducer, 61
DAAM1 dishevelled associated activator of morphogenesis 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DRAM1 DNA-damage regulated autophagy modulator 1
DST dystonin
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EHD1 EH-domain containing 1
ELL2 elongation factor, RNA polymerase II, 2
F3 coagulation factor III (thromboplastin, tissue factor)
FAS Fas cell surface death receptor
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO3 forkhead box O3
FZD6 frizzled class receptor 6
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GALC galactosylceramidase
GATAD1 GATA zinc finger domain containing 1
GEM GTP binding protein overexpressed in skeletal muscle
GLUL glutamate-ammonia ligase
GOLGA8H golgin A8 family, member H
GSE1 Gse1 coiled-coil protein
HBEGF heparin-binding EGF-like growth factor
HMOX1 heme oxygenase 1
IER2 immediate early response 2
IER5 immediate early response 5
IRS2 insulin receptor substrate 2
JMJD1C jumonji domain containing 1C
KAT6B K(lysine) acetyltransferase 6B
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KDM5D lysine (K)-specific demethylase 5D
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
KLF7 Kruppel-like factor 7 (ubiquitous)
KLF9 Kruppel-like factor 9
KYNU kynureninase
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LGALS3 lectin, galactoside-binding, soluble, 3
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
MED13 mediator complex subunit 13
MGLL monoglyceride lipase
MIR22HG MIR22 host gene
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOTCH2NL notch 2 N-terminal like
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPL1 nucleoporin like 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
QKI QKI, KH domain containing, RNA binding
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBM34 RNA binding motif protein 34
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RIOK3 RIO kinase 3
RND3 Rho family GTPase 3
RNMT RNA (guanine-7-) methyltransferase
RPS27L ribosomal protein S27-like
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RSL1D1 ribosomal L1 domain containing 1
SAMD4A sterile alpha motif domain containing 4A
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFTPB surfactant protein B
SIRT1 sirtuin 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC31A2 solute carrier family 31 (copper transporter), member 2
SMAD3 SMAD family member 3
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SNX11 sorting nexin 11
SOCS2 suppressor of cytokine signaling 2
STAG2 stromal antigen 2
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYNJ2 synaptojanin 2
TBX2 T-box 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNIP1 TNFAIP3 interacting protein 1
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TRIB1 tribbles pseudokinase 1
TUFT1 tuftelin 1
UBXN7 UBX domain protein 7
UGDH UDP-glucose 6-dehydrogenase
VEGFA vascular endothelial growth factor A
VEZF1 vascular endothelial zinc finger 1
WEE1 WEE1 G2 checkpoint kinase
ZMAT3 zinc finger, matrin-type 3
ZNF185 zinc finger protein 185 (LIM domain)
ZNF274 zinc finger protein 274

decreased expression

Symbol Name
ACOT7 acyl-CoA thioesterase 7
ADD3 adducin 3 (gamma)
ADI1 acireductone dioxygenase 1
AEBP1 AE binding protein 1
AGR2 anterior gradient 2
AHCYL1 adenosylhomocysteinase-like 1
ALG8 ALG8, alpha-1,3-glucosyltransferase
APITD1 apoptosis-inducing, TAF9-like domain 1
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BRCA1 breast cancer 1, early onset
C3 complement component 3
CACYBP calcyclin binding protein
CALD1 caldesmon 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCDC109B coiled-coil domain containing 109B
CCND3 cyclin D3
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CETN2 centrin, EF-hand protein, 2
CFB complement factor B
CFH complement factor H
CHEK2 checkpoint kinase 2
CLIC4 chloride intracellular channel 4
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CP ceruloplasmin (ferroxidase)
CXCL5 chemokine (C-X-C motif) ligand 5
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DEPTOR DEP domain containing MTOR-interacting protein
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DNM1 dynamin 1
DPYSL2 dihydropyrimidinase-like 2
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
E2F2 E2F transcription factor 2
EBP emopamil binding protein (sterol isomerase)
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
FEN1 flap structure-specific endonuclease 1
FGFR4 fibroblast growth factor receptor 4
FHL1 four and a half LIM domains 1
FKBP11 FK506 binding protein 11, 19 kDa
FN1 fibronectin 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPX3 glutathione peroxidase 3
HADH hydroxyacyl-CoA dehydrogenase
HAT1 histone acetyltransferase 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSPA1A heat shock 70kDa protein 1A
IGL immunoglobulin lambda locus
ITGB1BP1 integrin beta 1 binding protein 1
KAZN kazrin, periplakin interacting protein
LAPTM4B lysosomal protein transmembrane 4 beta
LCN2 lipocalin 2
LEF1 lymphoid enhancer-binding factor 1
LIG1 ligase I, DNA, ATP-dependent
LIPA lipase A, lysosomal acid, cholesterol esterase
LRRN3 leucine rich repeat neuronal 3
LYZ lysozyme
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MDK midkine (neurite growth-promoting factor 2)
MLPH melanophilin
MX1 MX dynamin-like GTPase 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
MYLK myosin light chain kinase
NLRP2 NLR family, pyrin domain containing 2
NQO2 NAD(P)H dehydrogenase, quinone 2
PBK PDZ binding kinase
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDIA4 protein disulfide isomerase family A, member 4
PDZK1 PDZ domain containing 1
PEBP1 phosphatidylethanolamine binding protein 1
PECR peroxisomal trans-2-enoyl-CoA reductase
PEG10 paternally expressed 10
PGD phosphogluconate dehydrogenase
PHGDH phosphoglycerate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PRAME preferentially expressed antigen in melanoma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PTGDS prostaglandin D2 synthase 21kDa (brain)
PYCR1 pyrroline-5-carboxylate reductase 1
QPRT quinolinate phosphoribosyltransferase
RANBP1 RAN binding protein 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBP4 retinol binding protein 4, plasma
RBPMS RNA binding protein with multiple splicing
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS1 regulator of G-protein signaling 1
RRM2 ribonucleotide reductase M2
SAMM50 SAMM50 sorting and assembly machinery component
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SNAP25 synaptosomal-associated protein, 25kDa
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SORBS1 sorbin and SH3 domain containing 1
SORD sorbitol dehydrogenase
SPP1 secreted phosphoprotein 1
SRM spermidine synthase
STEAP1 six transmembrane epithelial antigen of the prostate 1
STMN1 stathmin 1
TF transferrin
TFDP1 transcription factor Dp-1
TIMELESS timeless circadian clock
TMEM14A transmembrane protein 14A
TMEM97 transmembrane protein 97
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPM2 tropomyosin 2 (beta)
TSPAN13 tetraspanin 13
TUBG1 tubulin, gamma 1
VAV3 vav 3 guanine nucleotide exchange factor
VRK1 vaccinia related kinase 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WDR61 WD repeat domain 61
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta