BRD-K72541103_JAK3 Inhibitor I_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

57 genes differentially expressed following the BRD-K72541103_JAK3 Inhibitor I_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
BID BH3 interacting domain death agonist
CSRP2 cysteine and glycine-rich protein 2
CXCL9 chemokine (C-X-C motif) ligand 9
DES desmin
DPYSL3 dihydropyrimidinase-like 3
FAM129A family with sequence similarity 129, member A
FGFR3 fibroblast growth factor receptor 3
GREM1 gremlin 1, DAN family BMP antagonist
GUSBP11 glucuronidase, beta pseudogene 11
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
LMO3 LIM domain only 3 (rhombotin-like 2)
LYZ lysozyme
MTUS1 microtubule associated tumor suppressor 1
PALLD palladin, cytoskeletal associated protein
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDLIM3 PDZ and LIM domain 3
PEG10 paternally expressed 10
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
POU2AF1 POU class 2 associating factor 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RGCC regulator of cell cycle
SHB Src homology 2 domain containing adaptor protein B
SLC38A1 solute carrier family 38, member 1
SPARCL1 SPARC-like 1 (hevin)
SPRED2 sprouty-related, EVH1 domain containing 2
TNS1 tensin 1
TPD52 tumor protein D52
TRIL TLR4 interactor with leucine-rich repeats
TSPAN12 tetraspanin 12
UBE2J1 ubiquitin-conjugating enzyme E2, J1
ZMIZ1 zinc finger, MIZ-type containing 1

decreased expression

Symbol Name
ANPEP alanyl (membrane) aminopeptidase
BIRC2 baculoviral IAP repeat containing 2
C1S complement component 1, s subcomponent
C6ORF62 chromosome 6 open reading frame 62
CSTA cystatin A (stefin A)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
KCTD12 potassium channel tetramerization domain containing 12
KRT17 keratin 17, type I
KRT5 keratin 5, type II
LAGE3 L antigen family, member 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPL lipoprotein lipase
LTF lactotransferrin
PENK proenkephalin
PI3 peptidase inhibitor 3, skin-derived
PTX3 pentraxin 3, long
S100A7 S100 calcium binding protein A7
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP1 secreted frizzled-related protein 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10