BRD-K72541103_JAK3 Inhibitor I_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

119 genes differentially expressed following the BRD-K72541103_JAK3 Inhibitor I_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ASCL1 achaete-scute family bHLH transcription factor 1
ATP2A3 ATPase, Ca++ transporting, ubiquitous
C10ORF10 chromosome 10 open reading frame 10
CA12 carbonic anhydrase XII
CCNG2 cyclin G2
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CFD complement factor D (adipsin)
CHI3L2 chitinase 3-like 2
CLIC3 chloride intracellular channel 3
CPVL carboxypeptidase, vitellogenic-like
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CXCL13 chemokine (C-X-C motif) ligand 13
DSC3 desmocollin 3
DSP desmoplakin
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FGFR3 fibroblast growth factor receptor 3
GADD45B growth arrest and DNA-damage-inducible, beta
GJA1 gap junction protein, alpha 1, 43kDa
GPM6A glycoprotein M6A
GSE1 Gse1 coiled-coil protein
HILPDA hypoxia inducible lipid droplet-associated
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
ISG15 ISG15 ubiquitin-like modifier
KRT19 keratin 19, type I
LAMP3 lysosomal-associated membrane protein 3
LTBP1 latent transforming growth factor beta binding protein 1
MAOA monoamine oxidase A
MYBPC1 myosin binding protein C, slow type
NEBL nebulette
NLRP2 NLR family, pyrin domain containing 2
NUPR1 nuclear protein, transcriptional regulator, 1
PBX3 pre-B-cell leukemia homeobox 3
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PEG10 paternally expressed 10
PNMA1 paraneoplastic Ma antigen 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGES prostaglandin E synthase
PTX3 pentraxin 3, long
S100A7 S100 calcium binding protein A7
SCN3A sodium channel, voltage gated, type III alpha subunit
SDC2 syndecan 2
SNX11 sorting nexin 11
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TSC22D3 TSC22 domain family, member 3
TYMP thymidine phosphorylase
ZBTB16 zinc finger and BTB domain containing 16

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALB albumin
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ARL4C ADP-ribosylation factor-like 4C
ASPH aspartate beta-hydroxylase
BMP2 bone morphogenetic protein 2
C3 complement component 3
CAPN2 calpain 2, (m/II) large subunit
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
CCND2 cyclin D2
CKAP4 cytoskeleton-associated protein 4
CRISP3 cysteine-rich secretory protein 3
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYB5R2 cytochrome b5 reductase 2
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ERAP2 endoplasmic reticulum aminopeptidase 2
FERMT1 fermitin family member 1
FGF13 fibroblast growth factor 13
FLRT2 fibronectin leucine rich transmembrane protein 2
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
HBEGF heparin-binding EGF-like growth factor
HP haptoglobin
HSPH1 heat shock 105kDa/110kDa protein 1
ICAM1 intercellular adhesion molecule 1
IGF1 insulin-like growth factor 1 (somatomedin C)
INHBA inhibin, beta A
ITGA6 integrin, alpha 6
KIAA0101 KIAA0101
LAMC2 laminin, gamma 2
LCN2 lipocalin 2
LIF leukemia inhibitory factor
LPAR1 lysophosphatidic acid receptor 1
MCL1 myeloid cell leukemia 1
MMP9 matrix metallopeptidase 9
NET1 neuroepithelial cell transforming 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAUR plasminogen activator, urokinase receptor
PLK2 polo-like kinase 2
PRNP prion protein
PRR7 proline rich 7 (synaptic)
RANBP1 RAN binding protein 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS2 regulator of G-protein signaling 2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TSPAN8 tetraspanin 8
TYMS thymidylate synthetase
WFDC2 WAP four-disulfide core domain 2
WIF1 WNT inhibitory factor 1