BRD-K72541103_JAK3 Inhibitor I_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

191 genes differentially expressed following the BRD-K72541103_JAK3 Inhibitor I_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM10 ADAM metallopeptidase domain 10
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALOX5 arachidonate 5-lipoxygenase
ANXA4 annexin A4
ANXA9 annexin A9
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
BEX4 brain expressed, X-linked 4
BLNK B-cell linker
C10ORF10 chromosome 10 open reading frame 10
C3 complement component 3
CALD1 caldesmon 1
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFD complement factor D (adipsin)
CLDN3 claudin 3
CRABP2 cellular retinoic acid binding protein 2
CRYAB crystallin, alpha B
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DEPTOR DEP domain containing MTOR-interacting protein
DIO1 deiodinase, iodothyronine, type I
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FBLN1 fibulin 1
FGB fibrinogen beta chain
FGFR2 fibroblast growth factor receptor 2
FGG fibrinogen gamma chain
FN1 fibronectin 1
GRN granulin
GSTA1 glutathione S-transferase alpha 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
IFT57 intraflagellar transport 57
IGHM immunoglobulin heavy constant mu
INSM1 insulinoma-associated 1
KRT19 keratin 19, type I
KRT4 keratin 4, type II
LDOC1 leucine zipper, down-regulated in cancer 1
LPAR6 lysophosphatidic acid receptor 6
MAOA monoamine oxidase A
METTL7A methyltransferase like 7A
MME membrane metallo-endopeptidase
MMP7 matrix metallopeptidase 7
MSMB microseminoprotein, beta-
MUC1 mucin 1, cell surface associated
NEB nebulin
NUPR1 nuclear protein, transcriptional regulator, 1
NXN nucleoredoxin
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDZK1IP1 PDZK1 interacting protein 1
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PEX11A peroxisomal biogenesis factor 11 alpha
PLXNB2 plexin B2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PYCARD PYD and CARD domain containing
RAB21 RAB21, member RAS oncogene family
RGCC regulator of cell cycle
RTN1 reticulon 1
S100A8 S100 calcium binding protein A8
SCD5 stearoyl-CoA desaturase 5
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SGCE sarcoglycan, epsilon
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
STON1 stonin 1
SULF1 sulfatase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TCTA T-cell leukemia translocation altered
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPD52L1 tumor protein D52-like 1
TSC22D3 TSC22 domain family, member 3
TTC39A tetratricopeptide repeat domain 39A
UBE2J1 ubiquitin-conjugating enzyme E2, J1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGDH UDP-glucose 6-dehydrogenase
VAMP8 vesicle-associated membrane protein 8
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
VTCN1 V-set domain containing T cell activation inhibitor 1
YPEL5 yippee-like 5 (Drosophila)
ZHX2 zinc fingers and homeoboxes 2
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ASF1B anti-silencing function 1B histone chaperone
AURKA aurora kinase A
BATF3 basic leucine zipper transcription factor, ATF-like 3
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BLM Bloom syndrome, RecQ helicase-like
CANT1 calcium activated nucleotidase 1
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CETN3 centrin, EF-hand protein, 3
CHL1 cell adhesion molecule L1-like
CIT citron rho-interacting serine/threonine kinase
CKS2 CDC28 protein kinase regulatory subunit 2
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DHFR dihydrofolate reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
EFNB2 ephrin-B2
EPN2 epsin 2
ETV1 ets variant 1
ETV5 ets variant 5
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FGFR3 fibroblast growth factor receptor 3
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
HBEGF heparin-binding EGF-like growth factor
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HMGA1 high mobility group AT-hook 1
HOMER1 homer scaffolding protein 1
HOPX HOP homeobox
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IER3 immediate early response 3
IL13RA2 interleukin 13 receptor, alpha 2
ITM2A integral membrane protein 2A
JADE2 jade family PHD finger 2
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KLF4 Kruppel-like factor 4 (gut)
LAMC2 laminin, gamma 2
LIF leukemia inhibitory factor
LPAR1 lysophosphatidic acid receptor 1
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PLAC8 placenta-specific 8
PLAT plasminogen activator, tissue
PLAUR plasminogen activator, urokinase receptor
PMP22 peripheral myelin protein 22
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PRR7 proline rich 7 (synaptic)
RAD51C RAD51 paralog C
RGS2 regulator of G-protein signaling 2
RPA3 replication protein A3, 14kDa
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
S100A2 S100 calcium binding protein A2
SACS sacsin molecular chaperone
SATB2 SATB homeobox 2
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SHCBP1 SHC SH2-domain binding protein 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLIRP SRA stem-loop interacting RNA binding protein
SOX9 SRY (sex determining region Y)-box 9
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRY2 sprouty homolog 2 (Drosophila)
SRSF6 serine/arginine-rich splicing factor 6
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNJ2 synaptojanin 2
TFF3 trefoil factor 3 (intestinal)
TIAM1 T-cell lymphoma invasion and metastasis 1
TNC tenascin C
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPBG trophoblast glycoprotein
TRIP13 thyroid hormone receptor interactor 13
TSPAN8 tetraspanin 8
TYMS thymidylate synthetase
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2S ubiquitin-conjugating enzyme E2S
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZWINT ZW10 interacting kinetochore protein