BRD-K72541103_JAK3 Inhibitor I_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

87 genes differentially expressed following the BRD-K72541103_JAK3 Inhibitor I_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ADAMDEC1 ADAM-like, decysin 1
ADGRF5 adhesion G protein-coupled receptor F5
AHR aryl hydrocarbon receptor
AKR1C3 aldo-keto reductase family 1, member C3
CADM1 cell adhesion molecule 1
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
COL4A5 collagen, type IV, alpha 5
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
FRY furry homolog (Drosophila)
GCLC glutamate-cysteine ligase, catalytic subunit
GIMAP4 GTPase, IMAP family member 4
GSTT1 glutathione S-transferase theta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCTD12 potassium channel tetramerization domain containing 12
KDR kinase insert domain receptor
LDB2 LIM domain binding 2
LGALS2 lectin, galactoside-binding, soluble, 2
LOC100505650 uncharacterized LOC100505650
MNDA myeloid cell nuclear differentiation antigen
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
OPN3 opsin 3
PHACTR2 phosphatase and actin regulator 2
PMM2 phosphomannomutase 2
PRTN3 proteinase 3
PRUNE2 prune homolog 2 (Drosophila)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RCAN2 regulator of calcineurin 2
RGS5 regulator of G-protein signaling 5
SEPP1 selenoprotein P, plasma, 1
TFEC transcription factor EC
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
WT1 Wilms tumor 1

decreased expression

Symbol Name
AK4 adenylate kinase 4
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
APOD apolipoprotein D
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
CCL2 chemokine (C-C motif) ligand 2
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CXCL8 chemokine (C-X-C motif) ligand 8
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DEFB1 defensin, beta 1
DIRAS3 DIRAS family, GTP-binding RAS-like 3
DUSP5 dual specificity phosphatase 5
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
F3 coagulation factor III (thromboplastin, tissue factor)
GOLGA8A golgin A8 family, member A
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOMER1 homer scaffolding protein 1
IFI6 interferon, alpha-inducible protein 6
KRT23 keratin 23, type I
LDLR low density lipoprotein receptor
LRRC16A leucine rich repeat containing 16A
LY6D lymphocyte antigen 6 complex, locus D
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MOK MOK protein kinase
MT1E metallothionein 1E
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1X metallothionein 1X
NRIP3 nuclear receptor interacting protein 3
OXTR oxytocin receptor
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLP1 proteolipid protein 1
RCAN1 regulator of calcineurin 1
RRAGD Ras-related GTP binding D
S100A2 S100 calcium binding protein A2
S100B S100 calcium binding protein B
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SET SET nuclear proto-oncogene
SFRP1 secreted frizzled-related protein 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SRPX sushi-repeat containing protein, X-linked
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
ZC3H15 zinc finger CCCH-type containing 15