BRD-K72414522_AZD-5438_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

135 genes differentially expressed following the BRD-K72414522_AZD-5438_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACKR3 atypical chemokine receptor 3
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKAP12 A kinase (PRKA) anchor protein 12
ANKRD10 ankyrin repeat domain 10
ANOS1 anosmin 1
AP3D1 adaptor-related protein complex 3, delta 1 subunit
AREG amphiregulin
AXL AXL receptor tyrosine kinase
BEX1 brain expressed, X-linked 1
BHLHE40 basic helix-loop-helix family, member e40
BMP2 bone morphogenetic protein 2
CCND2 cyclin D2
CD163 CD163 molecule
CD44 CD44 molecule (Indian blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES2 carboxylesterase 2
CHERP calcium homeostasis endoplasmic reticulum protein
CLDND1 claudin domain containing 1
CLEC2B C-type lectin domain family 2, member B
COL4A6 collagen, type IV, alpha 6
CTSS cathepsin S
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CYBB cytochrome b-245, beta polypeptide
EIF5A eukaryotic translation initiation factor 5A
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP3 epithelial membrane protein 3
FJX1 four jointed box 1 (Drosophila)
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
GAA glucosidase, alpha; acid
GADD45A growth arrest and DNA-damage-inducible, alpha
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
GCLC glutamate-cysteine ligase, catalytic subunit
GPX1 glutathione peroxidase 1
HBEGF heparin-binding EGF-like growth factor
HMOX1 heme oxygenase 1
IFI16 interferon, gamma-inducible protein 16
IFI27 interferon, alpha-inducible protein 27
IL32 interleukin 32
LGALS2 lectin, galactoside-binding, soluble, 2
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MFAP5 microfibrillar associated protein 5
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1X metallothionein 1X
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NCAM1 neural cell adhesion molecule 1
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRNP prion protein
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PVALB parvalbumin
RALGDS ral guanine nucleotide dissociation stimulator
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RSL1D1 ribosomal L1 domain containing 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC4 syndecan 4
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SF1 splicing factor 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SOX9 SRY (sex determining region Y)-box 9
SPON1 spondin 1, extracellular matrix protein
SPRY2 sprouty homolog 2 (Drosophila)
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBX3 T-box 3
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
WT1 Wilms tumor 1
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
AQP3 aquaporin 3 (Gill blood group)
ARMCX2 armadillo repeat containing, X-linked 2
AURKA aurora kinase A
C10ORF10 chromosome 10 open reading frame 10
CCNA2 cyclin A2
CCNB2 cyclin B2
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDKN3 cyclin-dependent kinase inhibitor 3
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CENPA centromere protein A
CENPN centromere protein N
CENPU centromere protein U
COL5A2 collagen, type V, alpha 2
DEFB1 defensin, beta 1
DEPTOR DEP domain containing MTOR-interacting protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FABP4 fatty acid binding protein 4, adipocyte
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFX H2A histone family, member X
HDGFRP3 hepatoma-derived growth factor, related protein 3
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMGB3 high mobility group box 3
HN1 hematological and neurological expressed 1
HOXB7 homeobox B7
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JCHAIN joining chain of multimeric IgA and IgM
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIF20A kinesin family member 20A
KRT23 keratin 23, type I
LMNB1 lamin B1
LTF lactotransferrin
LUM lumican
MELK maternal embryonic leucine zipper kinase
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBK PDZ binding kinase
PRC1 protein regulator of cytokinesis 1
SAP30 Sin3A-associated protein, 30kDa
SEPHS1 selenophosphate synthetase 1
SMC4 structural maintenance of chromosomes 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
STMN1 stathmin 1
TACSTD2 tumor-associated calcium signal transducer 2
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFRC transferrin receptor
TOP2A topoisomerase (DNA) II alpha 170kDa
TRMT5 tRNA methyltransferase 5
TSPYL5 TSPY-like 5
UBE2C ubiquitin-conjugating enzyme E2C
VAT1 vesicle amine transport 1
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
WSB1 WD repeat and SOCS box containing 1