BRD-K72414522_AZD-5438_HS578T_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

215 genes differentially expressed following the BRD-K72414522_AZD-5438_HS578T_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AIF1 allograft inflammatory factor 1
AK4 adenylate kinase 4
AKAP8 A kinase (PRKA) anchor protein 8
AMPD3 adenosine monophosphate deaminase 3
ANK2 ankyrin 2, neuronal
ARL4C ADP-ribosylation factor-like 4C
ASS1 argininosuccinate synthase 1
BAG5 BCL2-associated athanogene 5
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BEX4 brain expressed, X-linked 4
BHLHE41 basic helix-loop-helix family, member e41
BLNK B-cell linker
BRD4 bromodomain containing 4
C1ORF116 chromosome 1 open reading frame 116
CCL20 chemokine (C-C motif) ligand 20
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCND1 cyclin D1
CD1E CD1e molecule
CD9 CD9 molecule
CDCP1 CUB domain containing protein 1
CES2 carboxylesterase 2
CNPY3 canopy FGF signaling regulator 3
COASY CoA synthase
COL11A1 collagen, type XI, alpha 1
COL9A2 collagen, type IX, alpha 2
CPVL carboxypeptidase, vitellogenic-like
CRABP1 cellular retinoic acid binding protein 1
CXADR coxsackie virus and adenovirus receptor
CXCL14 chemokine (C-X-C motif) ligand 14
DACH1 dachshund family transcription factor 1
DHCR24 24-dehydrocholesterol reductase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EGFL6 EGF-like-domain, multiple 6
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
F13A1 coagulation factor XIII, A1 polypeptide
FGFR2 fibroblast growth factor receptor 2
FRZB frizzled-related protein
GATA3 GATA binding protein 3
GLS glutaminase
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPC3 glypican 3
GPX3 glutathione peroxidase 3
GRB7 growth factor receptor-bound protein 7
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HBEGF heparin-binding EGF-like growth factor
HDAC9 histone deacetylase 9
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IL6R interleukin 6 receptor
JMJD6 jumonji domain containing 6
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCTD12 potassium channel tetramerization domain containing 12
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MARCH1 membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
MGAM maltase-glucoamylase
MSLN mesothelin
MSMO1 methylsterol monooxygenase 1
MUC16 mucin 16, cell surface associated
MXRA5 matrix-remodelling associated 5
NDRG1 N-myc downstream regulated 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
PDZK1IP1 PDZK1 interacting protein 1
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PNP purine nucleoside phosphorylase
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PPIF peptidylprolyl isomerase F
PPIG peptidylprolyl isomerase G (cyclophilin G)
PRR7 proline rich 7 (synaptic)
PTPRO protein tyrosine phosphatase, receptor type, O
RAB4A RAB4A, member RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBBP6 retinoblastoma binding protein 6
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RBM47 RNA binding motif protein 47
RIOK3 RIO kinase 3
RNASE6 ribonuclease, RNase A family, k6
RNMT RNA (guanine-7-) methyltransferase
RSL1D1 ribosomal L1 domain containing 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCG5 secretogranin V
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SOX9 SRY (sex determining region Y)-box 9
SPON1 spondin 1, extracellular matrix protein
SPRR1B small proline-rich protein 1B
TGFA transforming growth factor, alpha
TICAM1 toll-like receptor adaptor molecule 1
TMEM45A transmembrane protein 45A
TMEM5 transmembrane protein 5
TMEM97 transmembrane protein 97
TRPS1 trichorhinophalangeal syndrome I
TSPAN7 tetraspanin 7
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
UQCRH ubiquinol-cytochrome c reductase hinge protein
XIST X inactive specific transcript (non-protein coding)
ZC3H15 zinc finger CCCH-type containing 15
ZNF195 zinc finger protein 195
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
AK1 adenylate kinase 1
AKAP7 A kinase (PRKA) anchor protein 7
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
ANXA2 annexin A2
ANXA3 annexin A3
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATF5 activating transcription factor 5
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
BLMH bleomycin hydrolase
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C16ORF45 chromosome 16 open reading frame 45
C6ORF62 chromosome 6 open reading frame 62
C8ORF4 chromosome 8 open reading frame 4
CADM1 cell adhesion molecule 1
CAST calpastatin
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDC42 cell division cycle 42
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CENPF centromere protein F, 350/400kDa
CIRBP cold inducible RNA binding protein
COL5A1 collagen, type V, alpha 1
COL5A2 collagen, type V, alpha 2
CSRP1 cysteine and glycine-rich protein 1
CXCL12 chemokine (C-X-C motif) ligand 12
DAPK1 death-associated protein kinase 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DMD dystrophin
FOXO1 forkhead box O1
FSCN1 fascin actin-bundling protein 1
FSTL1 follistatin-like 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GAS1 growth arrest-specific 1
GRB10 growth factor receptor-bound protein 10
GSTM3 glutathione S-transferase mu 3 (brain)
GSTP1 glutathione S-transferase pi 1
GTPBP8 GTP-binding protein 8 (putative)
HLA-B major histocompatibility complex, class I, B
HLA-F major histocompatibility complex, class I, F
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1 hematological and neurological expressed 1
HOXB7 homeobox B7
HOXC6 homeobox C6
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI35 interferon-induced protein 35
IFRD2 interferon-related developmental regulator 2
IGHM immunoglobulin heavy constant mu
JAK1 Janus kinase 1
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
KLF2 Kruppel-like factor 2
LAMA3 laminin, alpha 3
LAMA4 laminin, alpha 4
LAMB1 laminin, beta 1
MARCKSL1 MARCKS-like 1
MCAM melanoma cell adhesion molecule
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYO10 myosin X
NBN nibrin
PBK PDZ binding kinase
PCM1 pericentriolar material 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDLIM5 PDZ and LIM domain 5
PEX11A peroxisomal biogenesis factor 11 alpha
PFN2 profilin 2
PLK1 polo-like kinase 1
PON2 paraoxonase 2
PON3 paraoxonase 3
PRC1 protein regulator of cytokinesis 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTTG1 pituitary tumor-transforming 1
RDX radixin
RHOBTB3 Rho-related BTB domain containing 3
RTN3 reticulon 3
SMC4 structural maintenance of chromosomes 4
SOX4 SRY (sex determining region Y)-box 4
SPC25 SPC25, NDC80 kinetochore complex component
SPP1 secreted phosphoprotein 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT1 signal transducer and activator of transcription 1, 91kDa
STMN1 stathmin 1
TCF12 transcription factor 12
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM50A transmembrane protein 50A
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TPX2 TPX2, microtubule-associated
TUBB tubulin, beta class I
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
WNT5A wingless-type MMTV integration site family, member 5A
WWTR1 WW domain containing transcription regulator 1