BRD-K72414522_AZD-5438_HME1_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

245 genes differentially expressed following the BRD-K72414522_AZD-5438_HME1_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACKR3 atypical chemokine receptor 3
ACP5 acid phosphatase 5, tartrate resistant
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AQP8 aquaporin 8
ARL4C ADP-ribosylation factor-like 4C
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
AZIN1 antizyme inhibitor 1
BHLHE41 basic helix-loop-helix family, member e41
C6ORF62 chromosome 6 open reading frame 62
C8ORF33 chromosome 8 open reading frame 33
CA11 carbonic anhydrase XI
CALB1 calbindin 1, 28kDa
CCDC47 coiled-coil domain containing 47
CCL20 chemokine (C-C motif) ligand 20
CD300A CD300a molecule
CELF2 CUGBP, Elav-like family member 2
CHERP calcium homeostasis endoplasmic reticulum protein
CLCA4 chloride channel accessory 4
CRABP1 cellular retinoic acid binding protein 1
CXADR coxsackie virus and adenovirus receptor
CXCL8 chemokine (C-X-C motif) ligand 8
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DOK5 docking protein 5
EIF3M eukaryotic translation initiation factor 3, subunit M
F12 coagulation factor XII (Hageman factor)
FGR FGR proto-oncogene, Src family tyrosine kinase
GATAD2A GATA zinc finger domain containing 2A
GCLC glutamate-cysteine ligase, catalytic subunit
GLS glutaminase
GOLT1B golgi transport 1B
GPR183 G protein-coupled receptor 183
HDAC9 histone deacetylase 9
HIRA histone cell cycle regulator
HMOX1 heme oxygenase 1
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
JAG1 jagged 1
KCMF1 potassium channel modulatory factor 1
KLK10 kallikrein-related peptidase 10
KRT13 keratin 13, type I
KRT19 keratin 19, type I
KRT4 keratin 4, type II
KRT6A keratin 6A, type II
LOC283683 uncharacterized LOC283683
LYN LYN proto-oncogene, Src family tyrosine kinase
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP2K3 mitogen-activated protein kinase kinase 3
MLF1 myeloid leukemia factor 1
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
MUC16 mucin 16, cell surface associated
MXI1 MAX interactor 1, dimerization protein
MXRA5 matrix-remodelling associated 5
NDP Norrie disease (pseudoglioma)
NGRN neugrin, neurite outgrowth associated
NOLC1 nucleolar and coiled-body phosphoprotein 1
NRIP1 nuclear receptor interacting protein 1
PELI1 pellino E3 ubiquitin protein ligase 1
PER2 period circadian clock 2
PHACTR1 phosphatase and actin regulator 1
PHF20 PHD finger protein 20
PLIN2 perilipin 2
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PRR7 proline rich 7 (synaptic)
PTDSS1 phosphatidylserine synthase 1
PTPRD protein tyrosine phosphatase, receptor type, D
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RABGGTB Rab geranylgeranyltransferase, beta subunit
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RBM15 RNA binding motif protein 15
RBP1 retinol binding protein 1, cellular
REG1A regenerating islet-derived 1 alpha
RIOK3 RIO kinase 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNMT RNA (guanine-7-) methyltransferase
RPS5 ribosomal protein S5
RRAD Ras-related associated with diabetes
RRAGD Ras-related GTP binding D
RSL1D1 ribosomal L1 domain containing 1
RUNX3 runt-related transcription factor 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SATB2 SATB homeobox 2
SCG5 secretogranin V
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERTAD2 SERTA domain containing 2
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SMAD7 SMAD family member 7
SMIM7 small integral membrane protein 7
SPON1 spondin 1, extracellular matrix protein
SPRR2B small proline-rich protein 2B
SST somatostatin
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TGFA transforming growth factor, alpha
TICAM1 toll-like receptor adaptor molecule 1
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TPD52 tumor protein D52
TSPAN7 tetraspanin 7
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VTCN1 V-set domain containing T cell activation inhibitor 1
WDR3 WD repeat domain 3
WDR45B WD repeat domain 45B
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZNF331 zinc finger protein 331
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ACSL3 acyl-CoA synthetase long-chain family member 3
ADAM10 ADAM metallopeptidase domain 10
ADGRG2 adhesion G protein-coupled receptor G2
AGR2 anterior gradient 2
AKAP7 A kinase (PRKA) anchor protein 7
AMIGO2 adhesion molecule with Ig-like domain 2
AQP3 aquaporin 3 (Gill blood group)
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATF5 activating transcription factor 5
AURKA aurora kinase A
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C10ORF10 chromosome 10 open reading frame 10
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CAST calpastatin
CAV2 caveolin 2
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNG2 cyclin G2
CDC20 cell division cycle 20
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CFH complement factor H
CKS2 CDC28 protein kinase regulatory subunit 2
COL4A5 collagen, type IV, alpha 5
COL5A2 collagen, type V, alpha 2
CTGF connective tissue growth factor
DCN decorin
DEPDC1 DEP domain containing 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DMD dystrophin
DPYSL2 dihydropyrimidinase-like 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAM129A family with sequence similarity 129, member A
FBN1 fibrillin 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOXM1 forkhead box M1
FZD7 frizzled class receptor 7
GAS1 growth arrest-specific 1
GLRX glutaredoxin (thioltransferase)
GTSE1 G-2 and S-phase expressed 1
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI16 interferon, gamma-inducible protein 16
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP6 insulin-like growth factor binding protein 6
IGHM immunoglobulin heavy constant mu
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JADE2 jade family PHD finger 2
KIF14 kinesin family member 14
KIF1BP KIF1 binding protein
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
LAMB1 laminin, beta 1
LBR lamin B receptor
LIMA1 LIM domain and actin binding 1
LOX lysyl oxidase
LOXL2 lysyl oxidase-like 2
LUM lumican
LXN latexin
MAGED1 melanoma antigen family D1
MAGED2 melanoma antigen family D2
MANSC1 MANSC domain containing 1
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MCM5 minichromosome maintenance complex component 5
MET MET proto-oncogene, receptor tyrosine kinase
MKI67 marker of proliferation Ki-67
MTUS1 microtubule associated tumor suppressor 1
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NEK7 NIMA-related kinase 7
NMI N-myc (and STAT) interactor
NNMT nicotinamide N-methyltransferase
NRP1 neuropilin 1
NUSAP1 nucleolar and spindle associated protein 1
OSBPL8 oxysterol binding protein-like 8
PBK PDZ binding kinase
PCM1 pericentriolar material 1
PLK1 polo-like kinase 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PRSS23 protease, serine, 23
PXDN peroxidasin
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RBPMS RNA binding protein with multiple splicing
RPS4Y1 ribosomal protein S4, Y-linked 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SFRP1 secreted frizzled-related protein 1
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SORBS1 sorbin and SH3 domain containing 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPC25 SPC25, NDC80 kinetochore complex component
STMN1 stathmin 1
STOM stomatin
TACC2 transforming, acidic coiled-coil containing protein 2
TACC3 transforming, acidic coiled-coil containing protein 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TMEM50A transmembrane protein 50A
TMSB15A thymosin beta 15a
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TPX2 TPX2, microtubule-associated
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
TTK TTK protein kinase
TXNIP thioredoxin interacting protein
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
VCAN versican
WNT5A wingless-type MMTV integration site family, member 5A
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)