BRD-K72414522_AZD-5438_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

279 genes differentially expressed following the BRD-K72414522_AZD-5438_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACKR3 atypical chemokine receptor 3
ADAMDEC1 ADAM-like, decysin 1
ADIRF adipogenesis regulatory factor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AIF1 allograft inflammatory factor 1
AKAP8 A kinase (PRKA) anchor protein 8
APOC1 apolipoprotein C-I
APOE apolipoprotein E
AQP1 aquaporin 1 (Colton blood group)
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
BAG5 BCL2-associated athanogene 5
BCL6 B-cell CLL/lymphoma 6
BHLHE41 basic helix-loop-helix family, member e41
BLNK B-cell linker
BRD2 bromodomain containing 2
BTG3 BTG family, member 3
C10ORF2 chromosome 10 open reading frame 2
C1QB complement component 1, q subcomponent, B chain
CA11 carbonic anhydrase XI
CA2 carbonic anhydrase II
CALML4 calmodulin-like 4
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCR1 chemokine (C-C motif) receptor 1
CD163 CD163 molecule
CD93 CD93 molecule
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CERS6 ceramide synthase 6
CFB complement factor B
CFI complement factor I
CHERP calcium homeostasis endoplasmic reticulum protein
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHPF chondroitin polymerizing factor
CLU clusterin
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DACH1 dachshund family transcription factor 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ESR1 estrogen receptor 1
FAM107A family with sequence similarity 107, member A
FAM110B family with sequence similarity 110, member B
FAM131A family with sequence similarity 131, member A
FAM63A family with sequence similarity 63, member A
FBXL12 F-box and leucine-rich repeat protein 12
FCGBP Fc fragment of IgG binding protein
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FGFR3 fibroblast growth factor receptor 3
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GLUL glutamate-ammonia ligase
GPC4 glypican 4
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GPR183 G protein-coupled receptor 183
GRB7 growth factor receptor-bound protein 7
GSTT1 glutathione S-transferase theta 1
GUSB glucuronidase, beta
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HMGN5 high mobility group nucleosome binding domain 5
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
IRF8 interferon regulatory factor 8
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIF5C kinesin family member 5C
LGALS4 lectin, galactoside-binding, soluble, 4
LOC100507397 uncharacterized LOC100507397
LST1 leukocyte specific transcript 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCTP1 multiple C2 domains, transmembrane 1
MECOM MDS1 and EVI1 complex locus
METTL7A methyltransferase like 7A
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MT1M metallothionein 1M
MUC2 mucin 2, oligomeric mucus/gel-forming
MXRA5 matrix-remodelling associated 5
NR4A2 nuclear receptor subfamily 4, group A, member 2
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PAX6 paired box 6
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDZD2 PDZ domain containing 2
PEG3 paternally expressed 3
PER2 period circadian clock 2
PHACTR1 phosphatase and actin regulator 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PLTP phospholipid transfer protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRR7 proline rich 7 (synaptic)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAB20 RAB20, member RAS oncogene family
RAE1 ribonucleic acid export 1
RAP1GAP2 RAP1 GTPase activating protein 2
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBM15 RNA binding motif protein 15
REG1A regenerating islet-derived 1 alpha
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RNASE6 ribonuclease, RNase A family, k6
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RNF144A ring finger protein 144A
RSL1D1 ribosomal L1 domain containing 1
S100A8 S100 calcium binding protein A8
SCG2 secretogranin II
SCG5 secretogranin V
SCGB2A1 secretoglobin, family 2A, member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SPARCL1 SPARC-like 1 (hevin)
SPATA5L1 spermatogenesis associated 5-like 1
SPON1 spondin 1, extracellular matrix protein
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
STK10 serine/threonine kinase 10
TICAM1 toll-like receptor adaptor molecule 1
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM30B transmembrane protein 30B
TOX thymocyte selection-associated high mobility group box
TPD52 tumor protein D52
TRIM2 tripartite motif containing 2
TWIST1 twist family bHLH transcription factor 1
TYROBP TYRO protein tyrosine kinase binding protein
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VSIG4 V-set and immunoglobulin domain containing 4
VWA5A von Willebrand factor A domain containing 5A
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF211 zinc finger protein 211
ZNF232 zinc finger protein 232
ZNF264 zinc finger protein 264
ZNF274 zinc finger protein 274
ZNF304 zinc finger protein 304
ZNF432 zinc finger protein 432
ZNF468 zinc finger protein 468
ZNF544 zinc finger protein 544
ZNF83 zinc finger protein 83

decreased expression

Symbol Name
ACTC1 actin, alpha, cardiac muscle 1
ADAM10 ADAM metallopeptidase domain 10
ADGRG2 adhesion G protein-coupled receptor G2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANXA7 annexin A7
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
APOD apolipoprotein D
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
AURKB aurora kinase B
BBX bobby sox homolog (Drosophila)
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BTG1 B-cell translocation gene 1, anti-proliferative
C8ORF4 chromosome 8 open reading frame 4
C9ORF3 chromosome 9 open reading frame 3
CAPN2 calpain 2, (m/II) large subunit
CAV2 caveolin 2
CCNB2 cyclin B2
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDCA3 cell division cycle associated 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CFLAR CASP8 and FADD-like apoptosis regulator
CKAP4 cytoskeleton-associated protein 4
CKS2 CDC28 protein kinase regulatory subunit 2
CNN1 calponin 1, basic, smooth muscle
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAPK1 death-associated protein kinase 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYSL2 dihydropyrimidinase-like 2
EIF5A eukaryotic translation initiation factor 5A
ELF5 E74-like factor 5 (ets domain transcription factor)
ENO1 enolase 1, (alpha)
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4
FAM129A family with sequence similarity 129, member A
FERMT2 fermitin family member 2
FN1 fibronectin 1
FNDC3B fibronectin type III domain containing 3B
FZD2 frizzled class receptor 2
FZD7 frizzled class receptor 7
GALE UDP-galactose-4-epimerase
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GLRX glutaredoxin (thioltransferase)
GRB10 growth factor receptor-bound protein 10
GTF2A2 general transcription factor IIA, 2, 12kDa
GTPBP8 GTP-binding protein 8 (putative)
GYG1 glycogenin 1
H1F0 H1 histone family, member 0
H3F3B H3 histone, family 3B (H3.3B)
HACD1 3-hydroxyacyl-CoA dehydratase 1
HAS2 hyaluronan synthase 2
HMGB1 high mobility group box 1
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ITGA6 integrin, alpha 6
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
MBNL1 muscleblind-like splicing regulator 1
MET MET proto-oncogene, receptor tyrosine kinase
MICALL1 MICAL-like 1
MKI67 marker of proliferation Ki-67
MSRB1 methionine sulfoxide reductase B1
MTUS1 microtubule associated tumor suppressor 1
MYBPC1 myosin binding protein C, slow type
NAP1L1 nucleosome assembly protein 1-like 1
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NEK7 NIMA-related kinase 7
NNMT nicotinamide N-methyltransferase
OSBPL8 oxysterol binding protein-like 8
PAIP1 poly(A) binding protein interacting protein 1
PAX8 paired box 8
PCM1 pericentriolar material 1
PDLIM5 PDZ and LIM domain 5
PGD phosphogluconate dehydrogenase
PKM pyruvate kinase, muscle
PLK1 polo-like kinase 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RCAN1 regulator of calcineurin 1
RDX radixin
REXO2 RNA exonuclease 2
RHOBTB3 Rho-related BTB domain containing 3
RPS27L ribosomal protein S27-like
SFRP1 secreted frizzled-related protein 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC38A1 solute carrier family 38, member 1
SMC4 structural maintenance of chromosomes 4
SOX4 SRY (sex determining region Y)-box 4
SRSF3 serine/arginine-rich splicing factor 3
STMN1 stathmin 1
TBC1D4 TBC1 domain family, member 4
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TNIP1 TNFAIP3 interacting protein 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TRAK2 trafficking protein, kinesin binding 2
TRIM29 tripartite motif containing 29
TST thiosulfate sulfurtransferase (rhodanese)
TTK TTK protein kinase
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGP2 UDP-glucose pyrophosphorylase 2
VCAN versican
ZBTB38 zinc finger and BTB domain containing 38