BRD-K72414522_AZD-5438_BT20_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

199 genes differentially expressed following the BRD-K72414522_AZD-5438_BT20_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD6 abhydrolase domain containing 6
ACKR3 atypical chemokine receptor 3
ANKRD10 ankyrin repeat domain 10
AP3D1 adaptor-related protein complex 3, delta 1 subunit
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BAG3 BCL2-associated athanogene 3
BCL2A1 BCL2-related protein A1
BCL6 B-cell CLL/lymphoma 6
C5AR1 complement component 5a receptor 1
CALML4 calmodulin-like 4
CCL20 chemokine (C-C motif) ligand 20
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN10 claudin 10
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CLU clusterin
COL6A1 collagen, type VI, alpha 1
COMP cartilage oligomeric matrix protein
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
F13A1 coagulation factor XIII, A1 polypeptide
FASTKD5 FAST kinase domains 5
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
FUCA1 fucosidase, alpha-L- 1, tissue
GAS7 growth arrest-specific 7
GSPT2 G1 to S phase transition 2
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGF1 insulin-like growth factor 1 (somatomedin C)
JMJD6 jumonji domain containing 6
KIAA0226L KIAA0226-like
LIF leukemia inhibitory factor
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MERTK MER proto-oncogene, tyrosine kinase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMD monocyte to macrophage differentiation-associated
NDP Norrie disease (pseudoglioma)
NME1 NME/NM23 nucleoside diphosphate kinase 1
NPAS2 neuronal PAS domain protein 2
NSDHL NAD(P) dependent steroid dehydrogenase-like
PEG3 paternally expressed 3
PER2 period circadian clock 2
PLIN2 perilipin 2
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRR7 proline rich 7 (synaptic)
PTX3 pentraxin 3, long
RBM34 RNA binding motif protein 34
RNMT RNA (guanine-7-) methyltransferase
RPIA ribose 5-phosphate isomerase A
RSL1D1 ribosomal L1 domain containing 1
SEPP1 selenoprotein P, plasma, 1
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SOD2 superoxide dismutase 2, mitochondrial
SORD sorbitol dehydrogenase
SPARCL1 SPARC-like 1 (hevin)
SPON1 spondin 1, extracellular matrix protein
STEAP1 six transmembrane epithelial antigen of the prostate 1
STK17B serine/threonine kinase 17b
TLR4 toll-like receptor 4
TM7SF2 transmembrane 7 superfamily member 2
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TPD52 tumor protein D52
TREM1 triggering receptor expressed on myeloid cells 1
TSPAN7 tetraspanin 7
TTC3 tetratricopeptide repeat domain 3
ZMAT3 zinc finger, matrin-type 3
ZNF195 zinc finger protein 195
ZNF330 zinc finger protein 330

decreased expression

Symbol Name
ADAM10 ADAM metallopeptidase domain 10
AMIGO2 adhesion molecule with Ig-like domain 2
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANXA1 annexin A1
ANXA3 annexin A3
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AQP3 aquaporin 3 (Gill blood group)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CAPN2 calpain 2, (m/II) large subunit
CAV2 caveolin 2
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CD200 CD200 molecule
CD69 CD69 molecule
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CRABP1 cellular retinoic acid binding protein 1
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CSRP1 cysteine and glycine-rich protein 1
CYR61 cysteine-rich, angiogenic inducer, 61
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DSP desmoplakin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFHD1 EF-hand domain family, member D1
EGFR epidermal growth factor receptor
ELF5 E74-like factor 5 (ets domain transcription factor)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB2 erb-b2 receptor tyrosine kinase 2
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM129A family with sequence similarity 129, member A
FAM64A family with sequence similarity 64, member A
FHL2 four and a half LIM domains 2
FOXM1 forkhead box M1
FST follistatin
FZD2 frizzled class receptor 2
GATA3 GATA binding protein 3
GTPBP8 GTP-binding protein 8 (putative)
GTSE1 G-2 and S-phase expressed 1
H1FX H1 histone family, member X
H2AFX H2A histone family, member X
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXB7 homeobox B7
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPA2 heat shock 70kDa protein 2
HSPB1 heat shock 27kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGF1R insulin-like growth factor 1 receptor
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGLV2-23 immunoglobulin lambda variable 2-23
JADE2 jade family PHD finger 2
JCHAIN joining chain of multimeric IgA and IgM
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KLHL9 kelch-like family member 9
KRT5 keratin 5, type II
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3 lectin, galactoside-binding, soluble, 3
LMNB1 lamin B1
MFAP2 microfibrillar-associated protein 2
MGP matrix Gla protein
MKI67 marker of proliferation Ki-67
MTUS1 microtubule associated tumor suppressor 1
MYOF myoferlin
NCAPG non-SMC condensin I complex, subunit G
NEK2 NIMA-related kinase 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NNMT nicotinamide N-methyltransferase
NUSAP1 nucleolar and spindle associated protein 1
PBK PDZ binding kinase
PHACTR2 phosphatase and actin regulator 2
PLK1 polo-like kinase 1
PLS3 plastin 3
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PON3 paraoxonase 3
PRC1 protein regulator of cytokinesis 1
PROM1 prominin 1
PSIP1 PC4 and SFRS1 interacting protein 1
PTPRK protein tyrosine phosphatase, receptor type, K
PTRF polymerase I and transcript release factor
PTTG1 pituitary tumor-transforming 1
RRM2 ribonucleotide reductase M2
S100A11 S100 calcium binding protein A11
S100A6 S100 calcium binding protein A6
SDC2 syndecan 2
SFRP1 secreted frizzled-related protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SMC4 structural maintenance of chromosomes 4
SOX4 SRY (sex determining region Y)-box 4
STMN1 stathmin 1
TACSTD2 tumor-associated calcium signal transducer 2
TAGLN2 transgelin 2
TLE4 transducin-like enhancer of split 4
TMEM50A transmembrane protein 50A
TMSB15A thymosin beta 15a
TOP2A topoisomerase (DNA) II alpha 170kDa
TOR1A torsin family 1, member A (torsin A)
TPM1 tropomyosin 1 (alpha)
TPX2 TPX2, microtubule-associated
TRIM2 tripartite motif containing 2
TUBA1A tubulin, alpha 1a
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TUBB6 tubulin, beta 6 class V
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
VIM vimentin
WNT5A wingless-type MMTV integration site family, member 5A
ZW10 zw10 kinetochore protein