BRD-K71835137_ethyl 3-(benzylthio)-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylate MAY_5_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

95 genes differentially expressed following the BRD-K71835137_ethyl 3-(benzylthio)-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylate MAY_5_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACE2 angiotensin I converting enzyme 2
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AKR1C3 aldo-keto reductase family 1, member C3
ALDOB aldolase B, fructose-bisphosphate
AMDHD2 amidohydrolase domain containing 2
CD36 CD36 molecule (thrombospondin receptor)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CPVL carboxypeptidase, vitellogenic-like
CRABP1 cellular retinoic acid binding protein 1
CXADR coxsackie virus and adenovirus receptor
CXCL5 chemokine (C-X-C motif) ligand 5
DDIT4 DNA-damage-inducible transcript 4
EDNRB endothelin receptor type B
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FBXL12 F-box and leucine-rich repeat protein 12
FHL1 four and a half LIM domains 1
FKBP10 FK506 binding protein 10, 65 kDa
GPC3 glypican 3
GPX3 glutathione peroxidase 3
GULP1 GULP, engulfment adaptor PTB domain containing 1
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent)
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
KLF4 Kruppel-like factor 4 (gut)
LAMA5 laminin, alpha 5
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MGAM maltase-glucoamylase
MTMR11 myotubularin related protein 11
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPTX2 neuronal pentraxin II
NTS neurotensin
PROM1 prominin 1
PRR7 proline rich 7 (synaptic)
PRSS2 protease, serine, 2 (trypsin 2)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RGS2 regulator of G-protein signaling 2
RGS5 regulator of G-protein signaling 5
RRAGD Ras-related GTP binding D
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TESC tescalcin
TFF1 trefoil factor 1
TMSB15A thymosin beta 15a
TRIB2 tribbles pseudokinase 2
TUBA1A tubulin, alpha 1a
TUBB6 tubulin, beta 6 class V
TUSC3 tumor suppressor candidate 3
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ANGPT1 angiopoietin 1
ASCC3 activating signal cointegrator 1 complex subunit 3
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CCL2 chemokine (C-C motif) ligand 2
CD14 CD14 molecule
CD163 CD163 molecule
CD24 CD24 molecule
CHI3L2 chitinase 3-like 2
COL10A1 collagen, type X, alpha 1
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
COL5A1 collagen, type V, alpha 1
COL5A2 collagen, type V, alpha 2
CTSK cathepsin K
CTTN cortactin
DAAM1 dishevelled associated activator of morphogenesis 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FTH1 ferritin, heavy polypeptide 1
H3F3B H3 histone, family 3B (H3.3B)
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HSPB8 heat shock 22kDa protein 8
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IRS2 insulin receptor substrate 2
KIAA1033 KIAA1033
KLK10 kallikrein-related peptidase 10
LMO3 LIM domain only 3 (rhombotin-like 2)
NAV3 neuron navigator 3
PCDH9 protocadherin 9
PERP PERP, TP53 apoptosis effector
RHOBTB3 Rho-related BTB domain containing 3
SCUBE2 signal peptide, CUB domain, EGF-like 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC39A8 solute carrier family 39 (zinc transporter), member 8
STEAP3 STEAP family member 3, metalloreductase
TDO2 tryptophan 2,3-dioxygenase
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFRC transferrin receptor
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
XIST X inactive specific transcript (non-protein coding)
ZBTB20 zinc finger and BTB domain containing 20