BRD-K71489689_2-(4-(tert-butyl)benzamido)-4,5-dichlorobenzoic acid KUC107686N_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

162 genes differentially expressed following the BRD-K71489689_2-(4-(tert-butyl)benzamido)-4,5-dichlorobenzoic acid KUC107686N_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
AKAP12 A kinase (PRKA) anchor protein 12
CALR calreticulin
CD34 CD34 molecule
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CRISP3 cysteine-rich secretory protein 3
CST6 cystatin E/M
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EZR ezrin
FBN2 fibrillin 2
FGB fibrinogen beta chain
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FST follistatin
GADD45B growth arrest and DNA-damage-inducible, beta
GHR growth hormone receptor
H1F0 H1 histone family, member 0
HEBP2 heme binding protein 2
IL1R2 interleukin 1 receptor, type II
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KDM7A lysine (K)-specific demethylase 7A
KRT19 keratin 19, type I
LAMA4 laminin, alpha 4
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MXI1 MAX interactor 1, dimerization protein
PCOLCE2 procollagen C-endopeptidase enhancer 2
PCP4 Purkinje cell protein 4
PHGDH phosphoglycerate dehydrogenase
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RBP4 retinol binding protein 4, plasma
RPL10 ribosomal protein L10
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFRP1 secreted frizzled-related protein 1
SNX7 sorting nexin 7
SOBP sine oculis binding protein homolog (Drosophila)
SPATS2L spermatogenesis associated, serine-rich 2-like
STC1 stanniocalcin 1
TF transferrin
TOPBP1 topoisomerase (DNA) II binding protein 1
TRIB3 tribbles pseudokinase 3

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABHD4 abhydrolase domain containing 4
ADI1 acireductone dioxygenase 1
AHR aryl hydrocarbon receptor
AQP3 aquaporin 3 (Gill blood group)
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
BMP2 bone morphogenetic protein 2
BPTF bromodomain PHD finger transcription factor
C6ORF62 chromosome 6 open reading frame 62
CCNB1 cyclin B1
CCND3 cyclin D3
CD38 CD38 molecule
CDK4 cyclin-dependent kinase 4
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLIC5 chloride intracellular channel 5
CPM carboxypeptidase M
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CSRP1 cysteine and glycine-rich protein 1
CTH cystathionine gamma-lyase
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DCK deoxycytidine kinase
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP10 dual specificity phosphatase 10
EIF1AX eukaryotic translation initiation factor 1A, X-linked
ELOVL5 ELOVL fatty acid elongase 5
FBXO21 F-box protein 21
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GCLC glutamate-cysteine ligase, catalytic subunit
GTPBP8 GTP-binding protein 8 (putative)
HAT1 histone acetyltransferase 1
HCCS holocytochrome c synthase
HOXD1 homeobox D1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA8 heat shock 70kDa protein 8
HSPB11 heat shock protein family B (small), member 11
HSPH1 heat shock 105kDa/110kDa protein 1
IFNGR1 interferon gamma receptor 1
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IL18 interleukin 18
IRS1 insulin receptor substrate 1
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KIAA1033 KIAA1033
KIF2C kinesin family member 2C
KTN1 kinectin 1 (kinesin receptor)
KYNU kynureninase
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LHFP lipoma HMGIC fusion partner
LUC7L3 LUC7-like 3 (S. cerevisiae)
LYPD1 LY6/PLAUR domain containing 1
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MFSD10 major facilitator superfamily domain containing 10
MRPL19 mitochondrial ribosomal protein L19
MSH6 mutS homolog 6
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEFH neurofilament, heavy polypeptide
NKTR natural killer cell triggering receptor
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUP62 nucleoporin 62kDa
OLFM4 olfactomedin 4
OSBPL8 oxysterol binding protein-like 8
PEG10 paternally expressed 10
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PIR pirin (iron-binding nuclear protein)
PLAC8 placenta-specific 8
PLS1 plastin 1
PPARG peroxisome proliferator-activated receptor gamma
PPIG peptidylprolyl isomerase G (cyclophilin G)
PRKCI protein kinase C, iota
PRPF4 pre-mRNA processing factor 4
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RAB14 RAB14, member RAS oncogene family
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RBM47 RNA binding motif protein 47
RRP1B ribosomal RNA processing 1B
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SMAD3 SMAD family member 3
SMS spermine synthase
SPEN spen family transcriptional repressor
SSR1 signal sequence receptor, alpha
STS steroid sulfatase (microsomal), isozyme S
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SYBU syntabulin (syntaxin-interacting)
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFRC transferrin receptor
THUMPD1 THUMP domain containing 1
TMEM106B transmembrane protein 106B
TMEM14A transmembrane protein 14A
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN8 tetraspanin 8
TUBB2B tubulin, beta 2B class IIb
TXNDC9 thioredoxin domain containing 9
UGCG UDP-glucose ceramide glucosyltransferase
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VAMP8 vesicle-associated membrane protein 8
VLDLR very low density lipoprotein receptor
WT1 Wilms tumor 1
XPO1 exportin 1
ZFP36L2 ZFP36 ring finger protein-like 2