BRD-K71172276_N-(4-methoxyphenyl)-4-morpholino-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-amine hw-gc-act02_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

122 genes differentially expressed following the BRD-K71172276_N-(4-methoxyphenyl)-4-morpholino-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-amine hw-gc-act02_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACPP acid phosphatase, prostate
ADGRG1 adhesion G protein-coupled receptor G1
AHNAK2 AHNAK nucleoprotein 2
CAPG capping protein (actin filament), gelsolin-like
CAST calpastatin
CHMP6 charged multivesicular body protein 6
CLGN calmegin
CLU clusterin
COL14A1 collagen, type XIV, alpha 1
CTSB cathepsin B
CXCL8 chemokine (C-X-C motif) ligand 8
DDAH1 dimethylarginine dimethylaminohydrolase 1
DUSP1 dual specificity phosphatase 1
EMP3 epithelial membrane protein 3
ENO2 enolase 2 (gamma, neuronal)
FAM129A family with sequence similarity 129, member A
FAS Fas cell surface death receptor
FTH1 ferritin, heavy polypeptide 1
G0S2 G0/G1 switch 2
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GNPDA1 glucosamine-6-phosphate deaminase 1
H3F3B H3 histone, family 3B (H3.3B)
HMGA2 high mobility group AT-hook 2
HMOX1 heme oxygenase 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL13RA2 interleukin 13 receptor, alpha 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KIAA1598
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MALL mal, T-cell differentiation protein-like
MAP1B microtubule-associated protein 1B
MAP7 microtubule-associated protein 7
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MMP1 matrix metallopeptidase 1
NAMPT nicotinamide phosphoribosyltransferase
NAV2 neuron navigator 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NELL2 NEL-like 2 (chicken)
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NID2 nidogen 2 (osteonidogen)
NOV nephroblastoma overexpressed
NR2F1 nuclear receptor subfamily 2, group F, member 1
PAIP1 poly(A) binding protein interacting protein 1
PCP4 Purkinje cell protein 4
PEG10 paternally expressed 10
PFN2 profilin 2
PRKCH protein kinase C, eta
PSAP prosaposin
RAB31 RAB31, member RAS oncogene family
RRAGD Ras-related GTP binding D
S100A2 S100 calcium binding protein A2
SFN stratifin
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
TFPI2 tissue factor pathway inhibitor 2
TSPYL5 TSPY-like 5
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VAT1 vesicle amine transport 1

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
AHR aryl hydrocarbon receptor
APOD apolipoprotein D
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
BAMBI BMP and activin membrane-bound inhibitor
CA2 carbonic anhydrase II
CD40 CD40 molecule, TNF receptor superfamily member 5
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CEMIP cell migration inducing protein, hyaluronan binding
CLTB clathrin, light chain B
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CTSE cathepsin E
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
DLX2 distal-less homeobox 2
EGR3 early growth response 3
ERBB3 erb-b2 receptor tyrosine kinase 3
FABP4 fatty acid binding protein 4, adipocyte
FXYD3 FXYD domain containing ion transport regulator 3
FZD7 frizzled class receptor 7
GSN gelsolin
HAT1 histone acetyltransferase 1
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMG20B high mobility group 20B
HNMT histamine N-methyltransferase
HOXB2 homeobox B2
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
KRT6B keratin 6B, type II
LGALS4 lectin, galactoside-binding, soluble, 4
LYZ lysozyme
MN1 meningioma (disrupted in balanced translocation) 1
MOK MOK protein kinase
MX2 MX dynamin-like GTPase 2
PCNA proliferating cell nuclear antigen
POSTN periostin, osteoblast specific factor
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
SDC2 syndecan 2
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
TCF4 transcription factor 4
TFF1 trefoil factor 1
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLR4 toll-like receptor 4
TMEM2 transmembrane protein 2
TPM1 tropomyosin 1 (alpha)
TRIM22 tripartite motif containing 22
TSPAN13 tetraspanin 13
WIF1 WNT inhibitory factor 1