BRD-K70917163_6-amino-1-[2-(3,4-dimethoxyphenyl)ethyl]-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone MLS000052933-02_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

196 genes differentially expressed following the BRD-K70917163_6-amino-1-[2-(3,4-dimethoxyphenyl)ethyl]-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone MLS000052933-02_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACOT7 acyl-CoA thioesterase 7
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDOC aldolase C, fructose-bisphosphate
AMD1 adenosylmethionine decarboxylase 1
AMDHD2 amidohydrolase domain containing 2
AQP3 aquaporin 3 (Gill blood group)
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATG2A autophagy related 2A
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BAG3 BCL2-associated athanogene 3
BLVRA biliverdin reductase A
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CCND3 cyclin D3
CDK19 cyclin-dependent kinase 19
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFD complement factor D (adipsin)
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CHEK2 checkpoint kinase 2
CHPT1 choline phosphotransferase 1
CIB1 calcium and integrin binding 1 (calmyrin)
COG5 component of oligomeric golgi complex 5
CTR9 CTR9, Paf1/RNA polymerase II complex component
CXCL5 chemokine (C-X-C motif) ligand 5
DLD dihydrolipoamide dehydrogenase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ECI2 enoyl-CoA delta isomerase 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4
FKBP14 FK506 binding protein 14, 22 kDa
FOXO4 forkhead box O4
FUCA1 fucosidase, alpha-L- 1, tissue
G6PD glucose-6-phosphate dehydrogenase
GADD45B growth arrest and DNA-damage-inducible, beta
GLRX glutaredoxin (thioltransferase)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GNS glucosamine (N-acetyl)-6-sulfatase
HEBP1 heme binding protein 1
HIST1H2BK histone cluster 1, H2bk
HLTF helicase-like transcription factor
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFT20 intraflagellar transport 20
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
JARID2 jumonji, AT rich interactive domain 2
KCTD5 potassium channel tetramerization domain containing 5
LAMP2 lysosomal-associated membrane protein 2
LEF1 lymphoid enhancer-binding factor 1
LIPA lipase A, lysosomal acid, cholesterol esterase
LITAF lipopolysaccharide-induced TNF factor
LPIN1 lipin 1
LRP4 low density lipoprotein receptor-related protein 4
MAB21L2 mab-21-like 2 (C. elegans)
MAGED1 melanoma antigen family D1
MAN2B1 mannosidase, alpha, class 2B, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MGST3 microsomal glutathione S-transferase 3
MLF1 myeloid leukemia factor 1
MPZL1 myelin protein zero-like 1
MXRA7 matrix-remodelling associated 7
NDRG3 NDRG family member 3
NEU1 sialidase 1 (lysosomal sialidase)
NOSIP nitric oxide synthase interacting protein
NPC2 Niemann-Pick disease, type C2
NUP98 nucleoporin 98kDa
NUPR1 nuclear protein, transcriptional regulator, 1
OAT ornithine aminotransferase
OPN3 opsin 3
OSBPL8 oxysterol binding protein-like 8
OSTM1 osteopetrosis associated transmembrane protein 1
PALLD palladin, cytoskeletal associated protein
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PHF20 PHD finger protein 20
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
PLA2G15 phospholipase A2, group XV
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PRAME preferentially expressed antigen in melanoma
PRDX1 peroxiredoxin 1
PROM1 prominin 1
PRPF4 pre-mRNA processing factor 4
PRSS3 protease, serine, 3
PTP4A1 protein tyrosine phosphatase type IVA, member 1
QPCT glutaminyl-peptide cyclotransferase
RAD9A RAD9 homolog A (S. pombe)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RCAN1 regulator of calcineurin 1
RFK riboflavin kinase
RIOK3 RIO kinase 3
RTN3 reticulon 3
SACS sacsin molecular chaperone
SAT1 spermidine/spermine N1-acetyltransferase 1
SCML1 sex comb on midleg-like 1 (Drosophila)
SEPT6 septin 6
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SKAP2 src kinase associated phosphoprotein 2
SNAP23 synaptosomal-associated protein, 23kDa
SNN stannin
SRGN serglycin
SRPX sushi-repeat containing protein, X-linked
STK17A serine/threonine kinase 17a
STXBP1 syntaxin binding protein 1
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TBC1D31 TBC1 domain family, member 31
TBC1D4 TBC1 domain family, member 4
TBPL1 TBP-like 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TM4SF1 transmembrane 4 L six family member 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRAK2 trafficking protein, kinesin binding 2
TRAM1 translocation associated membrane protein 1
TSNAX translin-associated factor X
TSPAN13 tetraspanin 13
TSPAN4 tetraspanin 4
TUFT1 tuftelin 1
UGCG UDP-glucose ceramide glucosyltransferase
VAT1 vesicle amine transport 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
XYLT1 xylosyltransferase I

decreased expression

Symbol Name
ANXA10 annexin A10
APOA2 apolipoprotein A-II
ARMCX2 armadillo repeat containing, X-linked 2
ASGR2 asialoglycoprotein receptor 2
ATF5 activating transcription factor 5
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BPTF bromodomain PHD finger transcription factor
CLC Charcot-Leyden crystal galectin
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
CPE carboxypeptidase E
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
DENND2D DENN/MADD domain containing 2D
DPYSL3 dihydropyrimidinase-like 3
EREG epiregulin
ESRP2 epithelial splicing regulatory protein 2
FAM129A family with sequence similarity 129, member A
FAM198B family with sequence similarity 198, member B
FBXO28 F-box protein 28
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FERMT1 fermitin family member 1
FOSL1 FOS-like antigen 1
GPX2 glutathione peroxidase 2
GSE1 Gse1 coiled-coil protein
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HOXB2 homeobox B2
IGHM immunoglobulin heavy constant mu
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta)
MECOM MDS1 and EVI1 complex locus
MPDU1 mannose-P-dolichol utilization defect 1
MPO myeloperoxidase
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYOF myoferlin
NVL nuclear VCP-like
OBSL1 obscurin-like 1
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PBX1 pre-B-cell leukemia homeobox 1
PBX3 pre-B-cell leukemia homeobox 3
PLK1 polo-like kinase 1
POGK pogo transposable element with KRAB domain
PTGIS prostaglandin I2 (prostacyclin) synthase
PWP1 PWP1 homolog (S. cerevisiae)
PXDN peroxidasin
RCAN2 regulator of calcineurin 2
RPL10 ribosomal protein L10
S100A8 S100 calcium binding protein A8
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STEAP3 STEAP family member 3, metalloreductase
SULF1 sulfatase 1
TDO2 tryptophan 2,3-dioxygenase
TF transferrin
TFR2 transferrin receptor 2
TMPO thymopoietin
TTC39A tetratricopeptide repeat domain 39A
UBE2J1 ubiquitin-conjugating enzyme E2, J1
USP1 ubiquitin specific peptidase 1
WARS tryptophanyl-tRNA synthetase
XIST X inactive specific transcript (non-protein coding)