BRD-K70917163_6-amino-1-[2-(3,4-dimethoxyphenyl)ethyl]-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone MLS000052933-02_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

224 genes differentially expressed following the BRD-K70917163_6-amino-1-[2-(3,4-dimethoxyphenyl)ethyl]-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone MLS000052933-02_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ACAD8 acyl-CoA dehydrogenase family, member 8
ACOT7 acyl-CoA thioesterase 7
ADA adenosine deaminase
ADIRF adipogenesis regulatory factor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDOC aldolase C, fructose-bisphosphate
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ARHGAP29 Rho GTPase activating protein 29
ASMTL acetylserotonin O-methyltransferase-like
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BSG basigin (Ok blood group)
BZW2 basic leucine zipper and W2 domains 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CD36 CD36 molecule (thrombospondin receptor)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CECR1 cat eye syndrome chromosome region, candidate 1
CFB complement factor B
CGA glycoprotein hormones, alpha polypeptide
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLU clusterin
CORO1A coronin, actin binding protein, 1A
CTH cystathionine gamma-lyase
CTR9 CTR9, Paf1/RNA polymerase II complex component
CTSA cathepsin A
CXCL13 chemokine (C-X-C motif) ligand 13
CYB5R1 cytochrome b5 reductase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
DCN decorin
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP14 dual specificity phosphatase 14
EDNRB endothelin receptor type B
EFHD1 EF-hand domain family, member D1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAM117A family with sequence similarity 117, member A
FOXO4 forkhead box O4
G0S2 G0/G1 switch 2
GABARAPL2 GABA(A) receptor-associated protein-like 2
GLS glutaminase
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNAS GNAS complex locus
GPER1 G protein-coupled estrogen receptor 1
GPX3 glutathione peroxidase 3
GSDMB gasdermin B
HBB hemoglobin, beta
HLA-B major histocompatibility complex, class I, B
HSPA1A heat shock 70kDa protein 1A
IGFBP5 insulin-like growth factor binding protein 5
INSIG1 insulin induced gene 1
IRF7 interferon regulatory factor 7
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
JCHAIN joining chain of multimeric IgA and IgM
KCTD5 potassium channel tetramerization domain containing 5
KIAA1467 KIAA1467
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LIMA1 LIM domain and actin binding 1
LPIN1 lipin 1
LUM lumican
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOB monoamine oxidase B
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MMP12 matrix metallopeptidase 12
NOSIP nitric oxide synthase interacting protein
NPC1 Niemann-Pick disease, type C1
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM1 olfactomedin 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PLA2G15 phospholipase A2, group XV
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RAD9A RAD9 homolog A (S. pombe)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RIMS3 regulating synaptic membrane exocytosis 3
RNASE6 ribonuclease, RNase A family, k6
RTN2 reticulon 2
SCPEP1 serine carboxypeptidase 1
SEPT6 septin 6
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SNN stannin
SPINK1 serine peptidase inhibitor, Kazal type 1
STAB1 stabilin 1
STAR steroidogenic acute regulatory protein
TM7SF2 transmembrane 7 superfamily member 2
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPST2 tyrosylprotein sulfotransferase 2
TSPAN13 tetraspanin 13
TSPAN31 tetraspanin 31
TSPAN7 tetraspanin 7
TTC39A tetratricopeptide repeat domain 39A
TUBB2A tubulin, beta 2A class IIa
TXNIP thioredoxin interacting protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WDTC1 WD and tetratricopeptide repeats 1
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANXA1 annexin A1
ANXA3 annexin A3
ARGLU1 arginine and glutamate rich 1
BTG3 BTG family, member 3
C1ORF106 chromosome 1 open reading frame 106
C9ORF3 chromosome 9 open reading frame 3
CA12 carbonic anhydrase XII
CADM1 cell adhesion molecule 1
CAPN2 calpain 2, (m/II) large subunit
CBFB core-binding factor, beta subunit
CBR3 carbonyl reductase 3
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
CDC42 cell division cycle 42
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
COL5A2 collagen, type V, alpha 2
CTPS1 CTP synthase 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKK1 dickkopf WNT signaling pathway inhibitor 1
EDN1 endothelin 1
EMP3 epithelial membrane protein 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPN2 epsin 2
EREG epiregulin
EXOSC4 exosome component 4
FAM57A family with sequence similarity 57, member A
FAM60A family with sequence similarity 60, member A
FOSL1 FOS-like antigen 1
FSCN1 fascin actin-bundling protein 1
GPX2 glutathione peroxidase 2
GRWD1 glutamate-rich WD repeat containing 1
GSAP gamma-secretase activating protein
HDGFRP3 hepatoma-derived growth factor, related protein 3
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HOXA10 homeobox A10
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IRS1 insulin receptor substrate 1
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
KRT18 keratin 18, type I
KRT7 keratin 7, type II
KYNU kynureninase
LAMC1 laminin, gamma 1 (formerly LAMB2)
LHX2 LIM homeobox 2
LYPD1 LY6/PLAUR domain containing 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP1B microtubule-associated protein 1B
MAPK6 mitogen-activated protein kinase 6
MDK midkine (neurite growth-promoting factor 2)
MET MET proto-oncogene, receptor tyrosine kinase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSLN mesothelin
NBN nibrin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NRIP1 nuclear receptor interacting protein 1
PARP2 poly (ADP-ribose) polymerase 2
PDGFA platelet-derived growth factor alpha polypeptide
PDGFC platelet derived growth factor C
PDLIM4 PDZ and LIM domain 4
PFAS phosphoribosylformylglycinamidine synthase
PIR pirin (iron-binding nuclear protein)
PLK1 polo-like kinase 1
PON2 paraoxonase 2
PRPF4 pre-mRNA processing factor 4
PRR7 proline rich 7 (synaptic)
PSCA prostate stem cell antigen
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTX3 pentraxin 3, long
QKI QKI, KH domain containing, RNA binding
RAD51C RAD51 paralog C
RBMS1 RNA binding motif, single stranded interacting protein 1
RPIA ribose 5-phosphate isomerase A
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SALL1 spalt-like transcription factor 1
SCG5 secretogranin V
SFRP1 secreted frizzled-related protein 1
SIK1 salt-inducible kinase 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SMAD3 SMAD family member 3
SPRR3 small proline-rich protein 3
SPRY2 sprouty homolog 2 (Drosophila)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCERG1 transcription elongation regulator 1
TFF1 trefoil factor 1
TM4SF1 transmembrane 4 L six family member 1
TNS3 tensin 3
TSKU tsukushi, small leucine rich proteoglycan
TSPAN8 tetraspanin 8
TXN thioredoxin
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UPK1B uroplakin 1B
VCAN versican
WEE1 WEE1 G2 checkpoint kinase
ZBTB20 zinc finger and BTB domain containing 20
ZNF532 zinc finger protein 532