BRD-K70792160_Akt inhibitor X_SW948_6.0_h_24.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

142 genes differentially expressed following the BRD-K70792160_Akt inhibitor X_SW948_6.0_h_24.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ARID5B AT rich interactive domain 5B (MRF1-like)
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BEX4 brain expressed, X-linked 4
BLNK B-cell linker
BTG3 BTG family, member 3
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CCND2 cyclin D2
CD9 CD9 molecule
COL15A1 collagen, type XV, alpha 1
COL5A2 collagen, type V, alpha 2
COLEC12 collectin sub-family member 12
CPE carboxypeptidase E
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CXADR coxsackie virus and adenovirus receptor
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DHRS3 dehydrogenase/reductase (SDR family) member 3
F11R F11 receptor
F13A1 coagulation factor XIII, A1 polypeptide
FAM129A family with sequence similarity 129, member A
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
GDF15 growth differentiation factor 15
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
HHEX hematopoietically expressed homeobox
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IL13RA1 interleukin 13 receptor, alpha 1
IL1R1 interleukin 1 receptor, type I
IPO13 importin 13
IQGAP1 IQ motif containing GTPase activating protein 1
LGALS1 lectin, galactoside-binding, soluble, 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LPPR4 lipid phosphate phosphatase-related protein type 4
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP3K7CL MAP3K7 C-terminal like
MKNK1 MAP kinase interacting serine/threonine kinase 1
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MSMB microseminoprotein, beta-
MXRA5 matrix-remodelling associated 5
NARFL nuclear prelamin A recognition factor-like
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NRGN neurogranin (protein kinase C substrate, RC3)
NUPR1 nuclear protein, transcriptional regulator, 1
NUSAP1 nucleolar and spindle associated protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK1 proprotein convertase subtilisin/kexin type 1
PHKG2 phosphorylase kinase, gamma 2 (testis)
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
POSTN periostin, osteoblast specific factor
PTPRF protein tyrosine phosphatase, receptor type, F
QPCT glutaminyl-peptide cyclotransferase
RAB13 RAB13, member RAS oncogene family
RAB25 RAB25, member RAS oncogene family
RAB31 RAB31, member RAS oncogene family
RNASE6 ribonuclease, RNase A family, k6
ROGDI rogdi homolog (Drosophila)
SDC2 syndecan 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFTPA2 surfactant protein A2
SGK1 serum/glucocorticoid regulated kinase 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SNAP29 synaptosomal-associated protein, 29kDa
SOCS2 suppressor of cytokine signaling 2
SULF1 sulfatase 1
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TIMP1 TIMP metallopeptidase inhibitor 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPBG trophoblast glycoprotein
TUSC3 tumor suppressor candidate 3
UBE2L6 ubiquitin-conjugating enzyme E2L 6
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ACLY ATP citrate lyase
AK1 adenylate kinase 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BTBD3 BTB (POZ) domain containing 3
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CDC20 cell division cycle 20
COCH cochlin
CSE1L CSE1 chromosome segregation 1-like (yeast)
EDF1 endothelial differentiation-related factor 1
EIF5A eukaryotic translation initiation factor 5A
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOLR1 folate receptor 1 (adult)
GRSF1 G-rich RNA sequence binding factor 1
HN1 hematological and neurological expressed 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
KAZN kazrin, periplakin interacting protein
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRRC16A leucine rich repeat containing 16A
MALL mal, T-cell differentiation protein-like
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MCOLN1 mucolipin 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NOLC1 nucleolar and coiled-body phosphoprotein 1
NRCAM neuronal cell adhesion molecule
NUP98 nucleoporin 98kDa
NUTF2 nuclear transport factor 2
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PLA2G16 phospholipase A2, group XVI
PLK2 polo-like kinase 2
PPA1 pyrophosphatase (inorganic) 1
PRMT1 protein arginine methyltransferase 1
PROM1 prominin 1
RAE1 ribonucleic acid export 1
RBMS1 RNA binding motif, single stranded interacting protein 1
RBP1 retinol binding protein 1, cellular
RFK riboflavin kinase
RPL22 ribosomal protein L22
RPL27A ribosomal protein L27a
RPL38 ribosomal protein L38
RPN2 ribophorin II
RPS11 ribosomal protein S11
SACS sacsin molecular chaperone
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SET SET nuclear proto-oncogene
SLPI secretory leukocyte peptidase inhibitor
SRPX sushi-repeat containing protein, X-linked
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TOMM34 translocase of outer mitochondrial membrane 34
TSPAN8 tetraspanin 8
UBE2S ubiquitin-conjugating enzyme E2S
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon