BRD-K70792160_Akt inhibitor X_SKM1_6.0_h_24.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

150 genes differentially expressed following the BRD-K70792160_Akt inhibitor X_SKM1_6.0_h_24.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANPEP alanyl (membrane) aminopeptidase
C2CD2 C2 calcium-dependent domain containing 2
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLIC4 chloride intracellular channel 4
CPT1A carnitine palmitoyltransferase 1A (liver)
CXCR4 chemokine (C-X-C motif) receptor 4
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DRAM1 DNA-damage regulated autophagy modulator 1
DSTN destrin (actin depolymerizing factor)
EDNRB endothelin receptor type B
FABP4 fatty acid binding protein 4, adipocyte
FDPS farnesyl diphosphate synthase
FSD1 fibronectin type III and SPRY domain containing 1
GAS6 growth arrest-specific 6
GSTA1 glutathione S-transferase alpha 1
HIST1H2BG histone cluster 1, H2bg
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOPX HOP homeobox
HSPA6 heat shock 70kDa protein 6 (HSP70B')
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
INSIG1 insulin induced gene 1
KLF6 Kruppel-like factor 6
MAP7 microtubule-associated protein 7
METRN meteorin, glial cell differentiation regulator
MMP19 matrix metallopeptidase 19
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCB4 phospholipase C, beta 4
RAB32 RAB32, member RAS oncogene family
RHOB ras homolog family member B
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SCARB2 scavenger receptor class B, member 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC1 syndecan 1
SEPT4 septin 4
SH3BGRL SH3 domain binding glutamate-rich protein like
SHB Src homology 2 domain containing adaptor protein B
SIK1 salt-inducible kinase 1
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
THY1 Thy-1 cell surface antigen
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
XIST X inactive specific transcript (non-protein coding)
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ADCY1 adenylate cyclase 1 (brain)
ADD3 adducin 3 (gamma)
ADRB2 adrenoceptor beta 2, surface
AK4 adenylate kinase 4
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ASCL1 achaete-scute family bHLH transcription factor 1
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
C1S complement component 1, s subcomponent
C6ORF48 chromosome 6 open reading frame 48
CCDC86 coiled-coil domain containing 86
CCNB2 cyclin B2
CDC42 cell division cycle 42
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CLU clusterin
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
CPE carboxypeptidase E
CSTA cystatin A (stefin A)
CXADR coxsackie virus and adenovirus receptor
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
DLK1 delta-like 1 homolog (Drosophila)
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DTNA dystrobrevin, alpha
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
ENOPH1 enolase-phosphatase 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FAM129A family with sequence similarity 129, member A
FAM134B family with sequence similarity 134, member B
FN1 fibronectin 1
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GAS1 growth arrest-specific 1
GCH1 GTP cyclohydrolase 1
GDF15 growth differentiation factor 15
GPC3 glypican 3
GRIA2 glutamate receptor, ionotropic, AMPA 2
GTPBP8 GTP-binding protein 8 (putative)
HIST1H4C histone cluster 1, H4c
HOMER1 homer scaffolding protein 1
IFRD2 interferon-related developmental regulator 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ITM2A integral membrane protein 2A
KIAA0101 KIAA0101
KIF5C kinesin family member 5C
KRT15 keratin 15, type I
LGALS3 lectin, galactoside-binding, soluble, 3
LMO2 LIM domain only 2 (rhombotin-like 1)
LTF lactotransferrin
LUM lumican
MAMLD1 mastermind-like domain containing 1
MB myoglobin
MGP matrix Gla protein
MME membrane metallo-endopeptidase
MMP7 matrix metallopeptidase 7
MSMB microseminoprotein, beta-
MT1X metallothionein 1X
MYBPC1 myosin binding protein C, slow type
MYO5C myosin VC
NAMPT nicotinamide phosphoribosyltransferase
NPY neuropeptide Y
NR1D2 nuclear receptor subfamily 1, group D, member 2
NRN1 neuritin 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PEG3 paternally expressed 3
PER2 period circadian clock 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAGL1 pleiomorphic adenoma gene-like 1
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PPL periplakin
PTX3 pentraxin 3, long
RBP1 retinol binding protein 1, cellular
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RHOBTB3 Rho-related BTB domain containing 3
RNF167 ring finger protein 167
RPL27A ribosomal protein L27a
RPS11 ribosomal protein S11
SCG5 secretogranin V
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SET SET nuclear proto-oncogene
SFRP1 secreted frizzled-related protein 1
SOBP sine oculis binding protein homolog (Drosophila)
SOSTDC1 sclerostin domain containing 1
SRSF6 serine/arginine-rich splicing factor 6
STX1A syntaxin 1A (brain)
STXBP2 syntaxin binding protein 2
SYNGR2 synaptogyrin 2
TEX10 testis expressed 10
TF transferrin
TFF3 trefoil factor 3 (intestinal)
TNNC1 troponin C type 1 (slow)
WFDC2 WAP four-disulfide core domain 2
WIF1 WNT inhibitory factor 1
ZNF185 zinc finger protein 185 (LIM domain)