BRD-K70792160_Akt inhibitor X_HT29_24.0_h_24.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

214 genes differentially expressed following the BRD-K70792160_Akt inhibitor X_HT29_24.0_h_24.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACKR3 atypical chemokine receptor 3
AGR2 anterior gradient 2
AIM1 absent in melanoma 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDOC aldolase C, fructose-bisphosphate
ANKRD10 ankyrin repeat domain 10
APOD apolipoprotein D
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
BASP1 brain abundant, membrane attached signal protein 1
BCL6 B-cell CLL/lymphoma 6
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BPIFA1 BPI fold containing family A, member 1
BTG1 B-cell translocation gene 1, anti-proliferative
CAPG capping protein (actin filament), gelsolin-like
CARS cysteinyl-tRNA synthetase
CCNG2 cyclin G2
CDK14 cyclin-dependent kinase 14
CDK19 cyclin-dependent kinase 19
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKAP4 cytoskeleton-associated protein 4
CLDN3 claudin 3
COLEC12 collectin sub-family member 12
CRABP2 cellular retinoic acid binding protein 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EXPH5 exophilin 5
FBN2 fibrillin 2
FOXN3 forkhead box N3
FOXO4 forkhead box O4
GLRX glutaredoxin (thioltransferase)
GOLGA4 golgin A4
GSDMB gasdermin B
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IGF2R insulin-like growth factor 2 receptor
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
JUN jun proto-oncogene
KLHL24 kelch-like family member 24
LCN2 lipocalin 2
LGALS3 lectin, galactoside-binding, soluble, 3
MKNK1 MAP kinase interacting serine/threonine kinase 1
MLPH melanophilin
MUC4 mucin 4, cell surface associated
MVP major vault protein
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC2 Niemann-Pick disease, type C2
NPIPB3 nuclear pore complex interacting protein family, member B3
NUPR1 nuclear protein, transcriptional regulator, 1
OSBPL10 oxysterol binding protein-like 10
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PRSS8 protease, serine, 8
RABAC1 Rab acceptor 1 (prenylated)
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RGCC regulator of cell cycle
RRAGC Ras-related GTP binding C
RRBP1 ribosome binding protein 1
S100A14 S100 calcium binding protein A14
SARS seryl-tRNA synthetase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELENBP1 selenium binding protein 1
SFRP4 secreted frizzled-related protein 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SPON2 spondin 2, extracellular matrix protein
SQSTM1 sequestosome 1
SYBU syntabulin (syntaxin-interacting)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TTC39A tetratricopeptide repeat domain 39A
TUBA1A tubulin, alpha 1a
VEGFA vascular endothelial growth factor A
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
AMD1 adenosylmethionine decarboxylase 1
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
AURKA aurora kinase A
BAG2 BCL2-associated athanogene 2
BOP1 block of proliferation 1
C1QBP complement component 1, q subcomponent binding protein
CACYBP calcyclin binding protein
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
COCH cochlin
COX11 COX11 cytochrome c oxidase copper chaperone
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTPS1 CTP synthase 1
CYCS cytochrome c, somatic
CYTL1 cytokine-like 1
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DLC1 DLC1 Rho GTPase activating protein
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1
EIF4E eukaryotic translation initiation factor 4E
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ENOSF1 enolase superfamily member 1
EXOSC2 exosome component 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTPBP4 GTP binding protein 4
HAT1 histone acetyltransferase 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HN1 hematological and neurological expressed 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA14 heat shock 70kDa protein 14
IL13RA2 interleukin 13 receptor, alpha 2
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MRPL20 mitochondrial ribosomal protein L20
MRPL3 mitochondrial ribosomal protein L3
MSH6 mutS homolog 6
MYBPC1 myosin binding protein C, slow type
MYCBP MYC binding protein
NCBP1 nuclear cap binding protein subunit 1, 80kDa
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NUP210 nucleoporin 210kDa
NUP85 nucleoporin 85kDa
NUP93 nucleoporin 93kDa
NUP98 nucleoporin 98kDa
NUTF2 nuclear transport factor 2
ODC1 ornithine decarboxylase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP1 poly (ADP-ribose) polymerase 1
PCNA proliferating cell nuclear antigen
PIGK phosphatidylinositol glycan anchor biosynthesis, class K
PLK1 polo-like kinase 1
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
PNO1 partner of NOB1 homolog (S. cerevisiae)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPAT phosphoribosyl pyrophosphate amidotransferase
PPIF peptidylprolyl isomerase F
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PTMA prothymosin, alpha
RBM12 RNA binding motif protein 12
RDX radixin
RFC3 replication factor C (activator 1) 3, 38kDa
RGS2 regulator of G-protein signaling 2
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUVBL1 RuvB-like AAA ATPase 1
SACS sacsin molecular chaperone
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor
SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae)
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLIRP SRA stem-loop interacting RNA binding protein
SMC1A structural maintenance of chromosomes 1A
SMC2 structural maintenance of chromosomes 2
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SNRPF small nuclear ribonucleoprotein polypeptide F
SNRPG small nuclear ribonucleoprotein polypeptide G
SPDL1 spindle apparatus coiled-coil protein 1
SRM spermidine synthase
SRSF1 serine/arginine-rich splicing factor 1
SRSF2 serine/arginine-rich splicing factor 2
SRSF7 serine/arginine-rich splicing factor 7
STAT1 signal transducer and activator of transcription 1, 91kDa
STOM stomatin
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TFAM transcription factor A, mitochondrial
TFRC transferrin receptor
TMEM47 transmembrane protein 47
TMPO thymopoietin
TOMM34 translocase of outer mitochondrial membrane 34
TRIP13 thyroid hormone receptor interactor 13
TYMS thymidylate synthetase
UMPS uridine monophosphate synthetase
USP1 ubiquitin specific peptidase 1
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein
Funding