BRD-K70792160_Akt inhibitor X_HEPG2_6.0_h_24.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

88 genes differentially expressed following the BRD-K70792160_Akt inhibitor X_HEPG2_6.0_h_24.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
AHNAK AHNAK nucleoprotein
APOD apolipoprotein D
BCAT1 branched chain amino-acid transaminase 1, cytosolic
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
COL6A1 collagen, type VI, alpha 1
COLEC12 collectin sub-family member 12
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
CYTH1 cytohesin 1
DDAH2 dimethylarginine dimethylaminohydrolase 2
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
ERBB3 erb-b2 receptor tyrosine kinase 3
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
ISLR immunoglobulin superfamily containing leucine-rich repeat
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LTF lactotransferrin
LY75 lymphocyte antigen 75
MDK midkine (neurite growth-promoting factor 2)
MSMO1 methylsterol monooxygenase 1
MYBPC1 myosin binding protein C, slow type
NMU neuromedin U
NQO1 NAD(P)H dehydrogenase, quinone 1
PFKM phosphofructokinase, muscle
PLBD1 phospholipase B domain containing 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
SC5D sterol-C5-desaturase
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPON2 spondin 2, extracellular matrix protein
SQLE squalene epoxidase
WDTC1 WD and tetratricopeptide repeats 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA1 annexin A1
BACE2 beta-site APP-cleaving enzyme 2
C1QBP complement component 1, q subcomponent binding protein
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DUSP6 dual specificity phosphatase 6
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1
ELL2 elongation factor, RNA polymerase II, 2
EPAS1 endothelial PAS domain protein 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FHL2 four and a half LIM domains 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GLIPR1 GLI pathogenesis-related 1
GRWD1 glutamate-rich WD repeat containing 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER3 immediate early response 3
ITM2A integral membrane protein 2A
KRT18 keratin 18, type I
KRT8 keratin 8, type II
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MCAM melanoma cell adhesion molecule
NNMT nicotinamide N-methyltransferase
NPY1R neuropeptide Y receptor Y1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLN phospholamban
PNO1 partner of NOB1 homolog (S. cerevisiae)
PRKACB protein kinase, cAMP-dependent, catalytic, beta
RGS5 regulator of G-protein signaling 5
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
TFRC transferrin receptor
TGFBI transforming growth factor, beta-induced, 68kDa
THBS1 thrombospondin 1
WFDC1 WAP four-disulfide core domain 1