BRD-K70792160_Akt inhibitor X_HCC515_6.0_h_24.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

60 genes differentially expressed following the BRD-K70792160_Akt inhibitor X_HCC515_6.0_h_24.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
BTG2 BTG family, member 2
CCNG2 cyclin G2
CD24 CD24 molecule
CSTA cystatin A (stefin A)
CXCL10 chemokine (C-X-C motif) ligand 10
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR24 24-dehydrocholesterol reductase
EFNA1 ephrin-A1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FBN1 fibrillin 1
GSTA1 glutathione S-transferase alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDI1 isopentenyl-diphosphate delta isomerase 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
INSIG1 insulin induced gene 1
KDM5D lysine (K)-specific demethylase 5D
KRT6B keratin 6B, type II
LDLR low density lipoprotein receptor
LOC100505650 uncharacterized LOC100505650
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP7 microtubule-associated protein 7
MBNL2 muscleblind-like splicing regulator 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MSMO1 methylsterol monooxygenase 1
PDZK1IP1 PDZK1 interacting protein 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SHB Src homology 2 domain containing adaptor protein B
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CCNA1 cyclin A1
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
DKK1 dickkopf WNT signaling pathway inhibitor 1
EIF5 eukaryotic translation initiation factor 5
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FBLN1 fibulin 1
G0S2 G0/G1 switch 2
GPM6B glycoprotein M6B
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
MT1M metallothionein 1M
PCDH9 protocadherin 9
PLAT plasminogen activator, tissue
PMEPA1 prostate transmembrane protein, androgen induced 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SPINK1 serine peptidase inhibitor, Kazal type 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STEAP1 six transmembrane epithelial antigen of the prostate 1
TSPAN13 tetraspanin 13
WTAP Wilms tumor 1 associated protein
XIST X inactive specific transcript (non-protein coding)
Funding