BRD-K70792160_Akt inhibitor X_HCC515_24.0_h_24.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

20 genes differentially expressed following the BRD-K70792160_Akt inhibitor X_HCC515_24.0_h_24.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
CA12 carbonic anhydrase XII
CAST calpastatin
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
FDFT1 farnesyl-diphosphate farnesyltransferase 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
INSIG1 insulin induced gene 1
MLPH melanophilin
MTSS1 metastasis suppressor 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A2 secretoglobin, family 2A, member 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
COL14A1 collagen, type XIV, alpha 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
IGFBP3 insulin-like growth factor binding protein 3
PRDX2 peroxiredoxin 2
RBP1 retinol binding protein 1, cellular
TSPAN13 tetraspanin 13