BRD-K70792160_Akt inhibitor X_A673_6.0_h_24.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

112 genes differentially expressed following the BRD-K70792160_Akt inhibitor X_A673_6.0_h_24.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTB actin, beta
APOD apolipoprotein D
CALML5 calmodulin-like 5
CCL8 chemokine (C-C motif) ligand 8
CLCA2 chloride channel accessory 2
CLCN3 chloride channel, voltage-sensitive 3
CLIC4 chloride intracellular channel 4
CRYM crystallin, mu
CXCL10 chemokine (C-X-C motif) ligand 10
DAPK1 death-associated protein kinase 1
EEF2 eukaryotic translation elongation factor 2
EGFR epidermal growth factor receptor
EIF5A eukaryotic translation initiation factor 5A
FABP7 fatty acid binding protein 7, brain
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA3 GATA binding protein 3
GLUL glutamate-ammonia ligase
GSTA4 glutathione S-transferase alpha 4
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
INSIG1 insulin induced gene 1
ITM2B integral membrane protein 2B
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LTF lactotransferrin
MAP7 microtubule-associated protein 7
MCOLN1 mucolipin 1
MMP7 matrix metallopeptidase 7
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
NRN1 neuritin 1
RALGDS ral guanine nucleotide dissociation stimulator
RNF167 ring finger protein 167
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPTBN1 spectrin, beta, non-erythrocytic 1
SQLE squalene epoxidase
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAP2 signal transducing adaptor family member 2
STX1A syntaxin 1A (brain)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TXNIP thioredoxin interacting protein
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ADGRG6 adhesion G protein-coupled receptor G6
ATMIN ATM interactor
CCNE2 cyclin E2
CLU clusterin
COL8A2 collagen, type VIII, alpha 2
COL9A3 collagen, type IX, alpha 3
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CRP C-reactive protein, pentraxin-related
CYBA cytochrome b-245, alpha polypeptide
DACT1 dishevelled-binding antagonist of beta-catenin 1
DLK1 delta-like 1 homolog (Drosophila)
EPHA3 EPH receptor A3
FABP1 fatty acid binding protein 1, liver
FOXF1 forkhead box F1
GREM1 gremlin 1, DAN family BMP antagonist
GSTM3 glutathione S-transferase mu 3 (brain)
HBB hemoglobin, beta
ICAM2 intercellular adhesion molecule 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ISG15 ISG15 ubiquitin-like modifier
KRT19 keratin 19, type I
KRT8 keratin 8, type II
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MGLL monoglyceride lipase
MGP matrix Gla protein
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1X metallothionein 1X
MT2A metallothionein 2A
NGRN neugrin, neurite outgrowth associated
ODC1 ornithine decarboxylase 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCP4 Purkinje cell protein 4
PDE10A phosphodiesterase 10A
PEG10 paternally expressed 10
PLK1 polo-like kinase 1
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PXDN peroxidasin
RPN1 ribophorin I
SGCE sarcoglycan, epsilon
SLC38A1 solute carrier family 38, member 1
SLC43A3 solute carrier family 43, member 3
SMNDC1 survival motor neuron domain containing 1
SRGN serglycin
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TFRC transferrin receptor
TLR4 toll-like receptor 4
TOB1 transducer of ERBB2, 1
ZFPM2 zinc finger protein, FOG family member 2
ZNF586 zinc finger protein 586