BRD-K70792160_Akt inhibitor X_A375_24.0_h_24.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

113 genes differentially expressed following the BRD-K70792160_Akt inhibitor X_A375_24.0_h_24.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ADGRG1 adhesion G protein-coupled receptor G1
AHNAK2 AHNAK nucleoprotein 2
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALDOC aldolase C, fructose-bisphosphate
AMIGO2 adhesion molecule with Ig-like domain 2
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BCL6 B-cell CLL/lymphoma 6
BZW2 basic leucine zipper and W2 domains 2
CDH19 cadherin 19, type 2
CDK14 cyclin-dependent kinase 14
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL15A1 collagen, type XV, alpha 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DCT dopachrome tautomerase
DHCR7 7-dehydrocholesterol reductase
DRAM1 DNA-damage regulated autophagy modulator 1
EPS8 epidermal growth factor receptor pathway substrate 8
FADS1 fatty acid desaturase 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FGG fibrinogen gamma chain
GATA6 GATA binding protein 6
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
LDLR low density lipoprotein receptor
LPXN leupaxin
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LXN latexin
MKNK1 MAP kinase interacting serine/threonine kinase 1
MSMO1 methylsterol monooxygenase 1
MVP major vault protein
MYOF myoferlin
NR1H2 nuclear receptor subfamily 1, group H, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRCAM neuronal cell adhesion molecule
NRP1 neuropilin 1
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
OSBPL10 oxysterol binding protein-like 10
PAM peptidylglycine alpha-amidating monooxygenase
PCP4 Purkinje cell protein 4
PEG10 paternally expressed 10
PRKD1 protein kinase D1
PRUNE2 prune homolog 2 (Drosophila)
S100A4 S100 calcium binding protein A4
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SFRP1 secreted frizzled-related protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOX10 SRY (sex determining region Y)-box 10
SPON2 spondin 2, extracellular matrix protein
SULF1 sulfatase 1
SVIL supervillin
TFPI2 tissue factor pathway inhibitor 2
TM7SF2 transmembrane 7 superfamily member 2
TMEM35 transmembrane protein 35
TRIM2 tripartite motif containing 2
TSC22D1 TSC22 domain family, member 1
VAT1 vesicle amine transport 1
WFDC1 WAP four-disulfide core domain 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ANXA3 annexin A3
ARMCX6 armadillo repeat containing, X-linked 6
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BRCA1 breast cancer 1, early onset
CASP7 caspase 7, apoptosis-related cysteine peptidase
CBX1 chromobox homolog 1
CCNF cyclin F
CDC42 cell division cycle 42
CENPU centromere protein U
CLC Charcot-Leyden crystal galectin
CTSG cathepsin G
CXCL14 chemokine (C-X-C motif) ligand 14
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FSTL1 follistatin-like 1
G0S2 G0/G1 switch 2
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFX H2A histone family, member X
HAT1 histone acetyltransferase 1
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HLTF helicase-like transcription factor
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
KLF4 Kruppel-like factor 4 (gut)
MCM5 minichromosome maintenance complex component 5
PDGFA platelet-derived growth factor alpha polypeptide
PDS5B PDS5 cohesin associated factor B
PLBD1 phospholipase B domain containing 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PTX3 pentraxin 3, long
RCN3 reticulocalbin 3, EF-hand calcium binding domain
RGS1 regulator of G-protein signaling 1
SACS sacsin molecular chaperone
SMC4 structural maintenance of chromosomes 4
SPARCL1 SPARC-like 1 (hevin)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TIPIN TIMELESS interacting protein
TRA2B transformer 2 beta homolog (Drosophila)
TRIP13 thyroid hormone receptor interactor 13
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
Funding