BRD-K70642949_GSK-2334470_PC3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

105 genes differentially expressed following the BRD-K70642949_GSK-2334470_PC3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
AGTR1 angiotensin II receptor, type 1
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
C2CD5 C2 calcium-dependent domain containing 5
C8ORF4 chromosome 8 open reading frame 4
CD9 CD9 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLU clusterin
CPM carboxypeptidase M
CXCL13 chemokine (C-X-C motif) ligand 13
CYR61 cysteine-rich, angiogenic inducer, 61
DDAH1 dimethylarginine dimethylaminohydrolase 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EGR1 early growth response 1
EMP1 epithelial membrane protein 1
FAR2 fatty acyl CoA reductase 2
GPM6A glycoprotein M6A
IGFBP7 insulin-like growth factor binding protein 7
IQCG IQ motif containing G
LOC100505650 uncharacterized LOC100505650
LY75 lymphocyte antigen 75
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
PBLD phenazine biosynthesis-like protein domain containing
PDE4D phosphodiesterase 4D, cAMP-specific
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PRSS23 protease, serine, 23
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
STAT1 signal transducer and activator of transcription 1, 91kDa
TEX10 testis expressed 10
TGIF1 TGFB-induced factor homeobox 1
TRH thyrotropin-releasing hormone
TSPAN13 tetraspanin 13
WEE1 WEE1 G2 checkpoint kinase
ZIC1 Zic family member 1

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACSL1 acyl-CoA synthetase long-chain family member 1
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANXA3 annexin A3
ATG3 autophagy related 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CA2 carbonic anhydrase II
CALML3 calmodulin-like 3
CALML5 calmodulin-like 5
CD36 CD36 molecule (thrombospondin receptor)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLCA2 chloride channel accessory 2
CNTNAP2 contactin associated protein-like 2
COL17A1 collagen, type XVII, alpha 1
COL8A2 collagen, type VIII, alpha 2
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CYB5A cytochrome b5 type A (microsomal)
DHCR7 7-dehydrocholesterol reductase
DPT dermatopontin
DSC3 desmocollin 3
FBLN2 fibulin 2
FLRT2 fibronectin leucine rich transmembrane protein 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GAL galanin/GMAP prepropeptide
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GPX3 glutathione peroxidase 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HP haptoglobin
IFRD2 interferon-related developmental regulator 2
IGFBP5 insulin-like growth factor binding protein 5
KLK5 kallikrein-related peptidase 5
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LTB lymphotoxin beta (TNF superfamily, member 3)
MFAP5 microfibrillar associated protein 5
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
PBX3 pre-B-cell leukemia homeobox 3
PDGFRL platelet-derived growth factor receptor-like
PLAGL1 pleiomorphic adenoma gene-like 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSPH phosphoserine phosphatase
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS5 regulator of G-protein signaling 5
S100A2 S100 calcium binding protein A2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFRP1 secreted frizzled-related protein 1
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS4 thrombospondin 4
ZBTB18 zinc finger and BTB domain containing 18
ZNF395 zinc finger protein 395