BRD-K70511574_sunitinib_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

152 genes differentially expressed following the BRD-K70511574_sunitinib_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANXA3 annexin A3
APOD apolipoprotein D
BAG3 BCL2-associated athanogene 3
BMI1 BMI1 proto-oncogene, polycomb ring finger
CDK17 cyclin-dependent kinase 17
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLGN calmegin
COCH cochlin
COL4A5 collagen, type IV, alpha 5
CRY1 cryptochrome circadian clock 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DBN1 drebrin 1
DCLK1 doublecortin-like kinase 1
DLC1 DLC1 Rho GTPase activating protein
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DST dystonin
FGF13 fibroblast growth factor 13
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
GPM6A glycoprotein M6A
GRB10 growth factor receptor-bound protein 10
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HOMER1 homer scaffolding protein 1
ICAM2 intercellular adhesion molecule 2
IER5 immediate early response 5
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
KIF20A kinesin family member 20A
LAPTM4B lysosomal protein transmembrane 4 beta
LY75 lymphocyte antigen 75
MAN1C1 mannosidase, alpha, class 1C, member 1
MAP1B microtubule-associated protein 1B
MICALL1 MICAL-like 1
MMP7 matrix metallopeptidase 7
MYO6 myosin VI
NPY1R neuropeptide Y receptor Y1
PDZK1IP1 PDZK1 interacting protein 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAC8 placenta-specific 8
PLK2 polo-like kinase 2
PNMAL1 paraneoplastic Ma antigen family-like 1
PODXL podocalyxin-like
POLR1D polymerase (RNA) I polypeptide D, 16kDa
POSTN periostin, osteoblast specific factor
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRR7 proline rich 7 (synaptic)
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SDPR serum deprivation response
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
TEX10 testis expressed 10
TFF1 trefoil factor 1
TNIK TRAF2 and NCK interacting kinase
TPBG trophoblast glycoprotein
TSPAN13 tetraspanin 13
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ACSL4 acyl-CoA synthetase long-chain family member 4
AK4 adenylate kinase 4
ANXA1 annexin A1
ARG1 arginase 1
BGN biglycan
C3AR1 complement component 3a receptor 1
CA12 carbonic anhydrase XII
CD24 CD24 molecule
CDC5L cell division cycle 5-like
CDK1 cyclin-dependent kinase 1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFH complement factor H
CHEK2 checkpoint kinase 2
CISH cytokine inducible SH2-containing protein
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
CPE carboxypeptidase E
CSTA cystatin A (stefin A)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3
DMD dystrophin
DPP4 dipeptidyl-peptidase 4
DSP desmoplakin
E2F2 E2F transcription factor 2
EMX2 empty spiracles homeobox 2
FST follistatin
GJA1 gap junction protein, alpha 1, 43kDa
H1F0 H1 histone family, member 0
HK2 hexokinase 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGA2 high mobility group AT-hook 2
IL1R1 interleukin 1 receptor, type I
IL1R2 interleukin 1 receptor, type II
INSIG1 insulin induced gene 1
IPO13 importin 13
KIF11 kinesin family member 11
LGALS3 lectin, galactoside-binding, soluble, 3
LINC00341 long intergenic non-protein coding RNA 341
MAL mal, T-cell differentiation protein
MAPT microtubule-associated protein tau
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MET MET proto-oncogene, receptor tyrosine kinase
MKNK1 MAP kinase interacting serine/threonine kinase 1
MMP2 matrix metallopeptidase 2
NDRG1 N-myc downstream regulated 1
NID2 nidogen 2 (osteonidogen)
NOTCH3 notch 3
NUSAP1 nucleolar and spindle associated protein 1
PAH phenylalanine hydroxylase
PAIP1 poly(A) binding protein interacting protein 1
PAPD7 PAP associated domain containing 7
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDGFRL platelet-derived growth factor receptor-like
PECR peroxisomal trans-2-enoyl-CoA reductase
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSPH phosphoserine phosphatase
RNASE4 ribonuclease, RNase A family, 4
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
SCGB2A1 secretoglobin, family 2A, member 1
SDC4 syndecan 4
SLPI secretory leukocyte peptidase inhibitor
SNX7 sorting nexin 7
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TM9SF3 transmembrane 9 superfamily member 3
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TOPBP1 topoisomerase (DNA) II binding protein 1
UBE2C ubiquitin-conjugating enzyme E2C
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
WNT5A wingless-type MMTV integration site family, member 5A
XBP1 X-box binding protein 1
ZNF395 zinc finger protein 395
ZWINT ZW10 interacting kinetochore protein