BRD-K70281171_U 99194 maleate_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

129 genes differentially expressed following the BRD-K70281171_U 99194 maleate_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADGRF5 adhesion G protein-coupled receptor F5
BPHL biphenyl hydrolase-like (serine hydrolase)
C10ORF10 chromosome 10 open reading frame 10
CD40 CD40 molecule, TNF receptor superfamily member 5
CDK14 cyclin-dependent kinase 14
CFDP1 craniofacial development protein 1
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
COG7 component of oligomeric golgi complex 7
CTNND1 catenin (cadherin-associated protein), delta 1
DENND1B DENN/MADD domain containing 1B
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
F11R F11 receptor
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HLA-B major histocompatibility complex, class I, B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOPX HOP homeobox
IFI16 interferon, gamma-inducible protein 16
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
ITM2C integral membrane protein 2C
JCHAIN joining chain of multimeric IgA and IgM
LGALS9 lectin, galactoside-binding, soluble, 9
LMO3 LIM domain only 3 (rhombotin-like 2)
LYN LYN proto-oncogene, Src family tyrosine kinase
MAGEA3 melanoma antigen family A3
MDK midkine (neurite growth-promoting factor 2)
MECOM MDS1 and EVI1 complex locus
MMP11 matrix metallopeptidase 11
MMP9 matrix metallopeptidase 9
NPIPB3 nuclear pore complex interacting protein family, member B3
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NR1H2 nuclear receptor subfamily 1, group H, member 2
NVL nuclear VCP-like
PAPD7 PAP associated domain containing 7
PEA15 phosphoprotein enriched in astrocytes 15
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PMM2 phosphomannomutase 2
PRUNE2 prune homolog 2 (Drosophila)
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTK2B protein tyrosine kinase 2 beta
PTN pleiotrophin
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE6 ribonuclease, RNase A family, k6
S100A8 S100 calcium binding protein A8
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SDC1 syndecan 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPON2 spondin 2, extracellular matrix protein
STAP1 signal transducing adaptor family member 1
SULF1 sulfatase 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TUBB2A tubulin, beta 2A class IIa
USP18 ubiquitin specific peptidase 18
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF274 zinc finger protein 274
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA3 annexin A3
ANXA5 annexin A5
ATMIN ATM interactor
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BASP1 brain abundant, membrane attached signal protein 1
CAPNS1 calpain, small subunit 1
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CELF2 CUGBP, Elav-like family member 2
CHPT1 choline phosphotransferase 1
CLU clusterin
COL9A3 collagen, type IX, alpha 3
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CST3 cystatin C
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL5 chemokine (C-X-C motif) ligand 5
CYBA cytochrome b-245, alpha polypeptide
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DKK1 dickkopf WNT signaling pathway inhibitor 1
FAM46A family with sequence similarity 46, member A
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GAS1 growth arrest-specific 1
GOLGA8A golgin A8 family, member A
HSPA1A heat shock 70kDa protein 1A
IL6ST interleukin 6 signal transducer
LYRM1 LYR motif containing 1
MBNL2 muscleblind-like splicing regulator 2
MRPS30 mitochondrial ribosomal protein S30
NFIB nuclear factor I/B
NQO1 NAD(P)H dehydrogenase, quinone 1
PDLIM5 PDZ and LIM domain 5
PHACTR2 phosphatase and actin regulator 2
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PSENEN presenilin enhancer gamma secretase subunit
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGES prostaglandin E synthase
QDPR quinoid dihydropteridine reductase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SACS sacsin molecular chaperone
SECISBP2L SECIS binding protein 2-like
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLIRP SRA stem-loop interacting RNA binding protein
SLPI secretory leukocyte peptidase inhibitor
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
TBCB tubulin folding cofactor B
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TMX4 thioredoxin-related transmembrane protein 4
TOB1 transducer of ERBB2, 1
ZEB2 zinc finger E-box binding homeobox 2