BRD-K70161581_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

97 genes differentially expressed following the BRD-K70161581_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AEBP1 AE binding protein 1
AGR2 anterior gradient 2
AK4 adenylate kinase 4
ALDOA aldolase A, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
AMIGO2 adhesion molecule with Ig-like domain 2
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C10ORF10 chromosome 10 open reading frame 10
CA9 carbonic anhydrase IX
CD24 CD24 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL11A1 collagen, type XI, alpha 1
COMP cartilage oligomeric matrix protein
DDIT4 DNA-damage-inducible transcript 4
DPYSL3 dihydropyrimidinase-like 3
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EGLN3 egl-9 family hypoxia-inducible factor 3
ENO2 enolase 2 (gamma, neuronal)
EPYC epiphycan
EXOSC4 exosome component 4
FHL1 four and a half LIM domains 1
FRY furry homolog (Drosophila)
GADD45B growth arrest and DNA-damage-inducible, beta
GBE1 glucan (1,4-alpha-), branching enzyme 1
GLRX glutaredoxin (thioltransferase)
GPX3 glutathione peroxidase 3
GRB10 growth factor receptor-bound protein 10
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
IGFBP3 insulin-like growth factor binding protein 3
IL6 interleukin 6
INSIG2 insulin induced gene 2
JMJD6 jumonji domain containing 6
KDM3A lysine (K)-specific demethylase 3A
LOX lysyl oxidase
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEFL neurofilament, light polypeptide
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PGK1 phosphoglycerate kinase 1
PKM pyruvate kinase, muscle
PLAU plasminogen activator, urokinase
PLCB4 phospholipase C, beta 4
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRAME preferentially expressed antigen in melanoma
PXDN peroxidasin
RCAN1 regulator of calcineurin 1
RNMT RNA (guanine-7-) methyltransferase
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SESN1 sestrin 1
SKAP2 src kinase associated phosphoprotein 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNX10 sorting nexin 10
SPAG4 sperm associated antigen 4
STC1 stanniocalcin 1
SULF1 sulfatase 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM45A transmembrane protein 45A
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNIP1 TNFAIP3 interacting protein 1
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
VIM vimentin
VLDLR very low density lipoprotein receptor

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDOB aldolase B, fructose-bisphosphate
CCNF cyclin F
CDC25B cell division cycle 25B
COL3A1 collagen, type III, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CXCL13 chemokine (C-X-C motif) ligand 13
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FGL2 fibrinogen-like 2
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
KIF20A kinesin family member 20A
MBOAT7 membrane bound O-acyltransferase domain containing 7
NRCAM neuronal cell adhesion molecule
PBK PDZ binding kinase
PLK1 polo-like kinase 1
PXMP2 peroxisomal membrane protein 2, 22kDa
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
UBE2C ubiquitin-conjugating enzyme E2C