BRD-K69932463_AZD-8055_MCF10A_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

273 genes differentially expressed following the BRD-K69932463_AZD-8055_MCF10A_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABLIM3 actin binding LIM protein family, member 3
ADAM28 ADAM metallopeptidase domain 28
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AHNAK AHNAK nucleoprotein
AHNAK2 AHNAK nucleoprotein 2
ALCAM activated leukocyte cell adhesion molecule
ALDOC aldolase C, fructose-bisphosphate
AMOTL2 angiomotin like 2
ANXA4 annexin A4
ANXA5 annexin A5
APOD apolipoprotein D
ATP9A ATPase, class II, type 9A
BASP1 brain abundant, membrane attached signal protein 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C10ORF10 chromosome 10 open reading frame 10
CAMLG calcium modulating ligand
CAPN1 calpain 1, (mu/I) large subunit
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDK19 cyclin-dependent kinase 19
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CFB complement factor B
CFD complement factor D (adipsin)
CIRBP cold inducible RNA binding protein
COL6A1 collagen, type VI, alpha 1
CRIP1 cysteine-rich protein 1 (intestinal)
CTSK cathepsin K
DARS aspartyl-tRNA synthetase
DCN decorin
DDAH2 dimethylarginine dimethylaminohydrolase 2
DIAPH2 diaphanous-related formin 2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EGFR epidermal growth factor receptor
EMP1 epithelial membrane protein 1
ENO2 enolase 2 (gamma, neuronal)
EPS8 epidermal growth factor receptor pathway substrate 8
ERBB2 erb-b2 receptor tyrosine kinase 2
F13A1 coagulation factor XIII, A1 polypeptide
FABP4 fatty acid binding protein 4, adipocyte
FADS3 fatty acid desaturase 3
FAXDC2 fatty acid hydroxylase domain containing 2
FBLN1 fibulin 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
FZD7 frizzled class receptor 7
G0S2 G0/G1 switch 2
GAS6 growth arrest-specific 6
GDI1 GDP dissociation inhibitor 1
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GPX3 glutathione peroxidase 3
GPX4 glutathione peroxidase 4
GRN granulin
GSN gelsolin
HBP1 HMG-box transcription factor 1
HMGA2 high mobility group AT-hook 2
IDS iduronate 2-sulfatase
IGBP1 immunoglobulin (CD79A) binding protein 1
IGFBP3 insulin-like growth factor binding protein 3
IL1R1 interleukin 1 receptor, type I
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGAV integrin, alpha V
ITGB4 integrin, beta 4
ITGB5 integrin, beta 5
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JAG1 jagged 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KDM5B lysine (K)-specific demethylase 5B
LAMC2 laminin, gamma 2
LDOC1 leucine zipper, down-regulated in cancer 1
LEPR leptin receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LIMS1 LIM and senescent cell antigen-like domains 1
LINC00341 long intergenic non-protein coding RNA 341
LOXL1 lysyl oxidase-like 1
LRP1 low density lipoprotein receptor-related protein 1
LTBP1 latent transforming growth factor beta binding protein 1
LTBP3 latent transforming growth factor beta binding protein 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MET MET proto-oncogene, receptor tyrosine kinase
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
MGLL monoglyceride lipase
MT1F metallothionein 1F
MTMR11 myotubularin related protein 11
MTSS1 metastasis suppressor 1
MUC1 mucin 1, cell surface associated
NCF2 neutrophil cytosolic factor 2
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NMNAT2 nicotinamide nucleotide adenylyltransferase 2
NT5E 5'-nucleotidase, ecto (CD73)
OPTN optineurin
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PGLS 6-phosphogluconolactonase
PHF20 PHD finger protein 20
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLXNB2 plexin B2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPAP2B phosphatidic acid phosphatase type 2B
PPL periplakin
PTK2B protein tyrosine kinase 2 beta
RBKS ribokinase
RRAS related RAS viral (r-ras) oncogene homolog
SAT1 spermidine/spermine N1-acetyltransferase 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFXN3 sideroflexin 3
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
SOD2 superoxide dismutase 2, mitochondrial
SOS2 son of sevenless homolog 2 (Drosophila)
SOX4 SRY (sex determining region Y)-box 4
SQSTM1 sequestosome 1
SRPX sushi-repeat containing protein, X-linked
SULF1 sulfatase 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMP2 TIMP metallopeptidase inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TNIP1 TNFAIP3 interacting protein 1
TNS3 tensin 3
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1
VCAN versican
VNN1 vanin 1
VSIG4 V-set and immunoglobulin domain containing 4
WDR13 WD repeat domain 13
ZC2HC1A zinc finger, C2HC-type containing 1A
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASF1B anti-silencing function 1B histone chaperone
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
AURKA aurora kinase A
BAG2 BCL2-associated athanogene 2
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
C1QBP complement component 1, q subcomponent binding protein
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNF cyclin F
CD320 CD320 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CENPN centromere protein N
CENPU centromere protein U
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSRP2 cysteine and glycine-rich protein 2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYCS cytochrome c, somatic
DBF4 DBF4 zinc finger
DDIT4 DNA-damage-inducible transcript 4
DEPDC1 DEP domain containing 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ELOVL6 ELOVL fatty acid elongase 6
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GAL galanin/GMAP prepropeptide
GBP1 guanylate binding protein 1, interferon-inducible
GCH1 GTP cyclohydrolase 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
GTSE1 G-2 and S-phase expressed 1
H2AFZ H2A histone family, member Z
HCP5 HLA complex P5 (non-protein coding)
HIST1H4C histone cluster 1, H4c
ICMT isoprenylcysteine carboxyl methyltransferase
IFI44 interferon-induced protein 44
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
LBR lamin B receptor
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LRRC59 leucine rich repeat containing 59
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MALL mal, T-cell differentiation protein-like
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MLEC malectin
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NCAPG2 non-SMC condensin II complex, subunit G2
NLRP2 NLR family, pyrin domain containing 2
NOLC1 nucleolar and coiled-body phosphoprotein 1
NPY neuropeptide Y
NUP107 nucleoporin 107kDa
NUP98 nucleoporin 98kDa
NUSAP1 nucleolar and spindle associated protein 1
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PFAS phosphoribosylformylglycinamidine synthase
PHGDH phosphoglycerate dehydrogenase
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PLS1 plastin 1
PNP purine nucleoside phosphorylase
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD)
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRPF4 pre-mRNA processing factor 4
PSAT1 phosphoserine aminotransferase 1
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PSPH phosphoserine phosphatase
RACGAP1 Rac GTPase activating protein 1
RAD51C RAD51 paralog C
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RPA2 replication protein A2, 32kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SCML1 sex comb on midleg-like 1 (Drosophila)
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SORD sorbitol dehydrogenase
SRSF3 serine/arginine-rich splicing factor 3
STMN1 stathmin 1
SUB1 SUB1 homolog (S. cerevisiae)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TESC tescalcin
TFAM transcription factor A, mitochondrial
TMEM194A transmembrane protein 194A
TMEM38B transmembrane protein 38B
TMEM97 transmembrane protein 97
TMPO thymopoietin
TRIP13 thyroid hormone receptor interactor 13
TSPAN8 tetraspanin 8
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UBE2S ubiquitin-conjugating enzyme E2S
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
VDAC3 voltage-dependent anion channel 3
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein