BRD-K69932463_AZD-8055_LNCAP_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

90 genes differentially expressed following the BRD-K69932463_AZD-8055_LNCAP_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ANKRD36B ankyrin repeat domain 36B
ANXA5 annexin A5
ARID5B AT rich interactive domain 5B (MRF1-like)
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD44 CD44 molecule (Indian blood group)
CLEC2B C-type lectin domain family 2, member B
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL8 chemokine (C-X-C motif) ligand 8
EPS8 epidermal growth factor receptor pathway substrate 8
FAM13A family with sequence similarity 13, member A
FAM46A family with sequence similarity 46, member A
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GOLM1 golgi membrane protein 1
GPC4 glypican 4
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HMGB2 high mobility group box 2
HMOX1 heme oxygenase 1
IL17RB interleukin 17 receptor B
KDM3A lysine (K)-specific demethylase 3A
LDLR low density lipoprotein receptor
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MATN2 matrilin 2
MBNL2 muscleblind-like splicing regulator 2
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
NCALD neurocalcin delta
NFIB nuclear factor I/B
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDZRN3 PDZ domain containing ring finger 3
RORA RAR-related orphan receptor A
SAT1 spermidine/spermine N1-acetyltransferase 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SOX4 SRY (sex determining region Y)-box 4
SRPX sushi-repeat containing protein, X-linked
SRRM2 serine/arginine repetitive matrix 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR3 transforming growth factor, beta receptor III
TNIK TRAF2 and NCK interacting kinase
VCAN versican
WISP2 WNT1 inducible signaling pathway protein 2
ZNF292 zinc finger protein 292

decreased expression

Symbol Name
AGR2 anterior gradient 2
AIM1 absent in melanoma 1
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
BEX1 brain expressed, X-linked 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD24 CD24 molecule
CDC25A cell division cycle 25A
CFH complement factor H
CLCA4 chloride channel accessory 4
CLU clusterin
CP ceruloplasmin (ferroxidase)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CYB5A cytochrome b5 type A (microsomal)
DACH1 dachshund family transcription factor 1
DDIT4 DNA-damage-inducible transcript 4
DICER1 dicer 1, ribonuclease type III
ECM1 extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
GRIA2 glutamate receptor, ionotropic, AMPA 2
HILPDA hypoxia inducible lipid droplet-associated
HSPA1A heat shock 70kDa protein 1A
IGKV4-1 immunoglobulin kappa variable 4-1
LCN2 lipocalin 2
MAT2A methionine adenosyltransferase II, alpha
MEIS1 Meis homeobox 1
MEIS2 Meis homeobox 2
MID1IP1 MID1 interacting protein 1
NR2F6 nuclear receptor subfamily 2, group F, member 6
PITX1 paired-like homeodomain 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSAT1 phosphoserine aminotransferase 1
PSCA prostate stem cell antigen
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RBM15B RNA binding motif protein 15B
RTN1 reticulon 1
SNAP25 synaptosomal-associated protein, 25kDa
SST somatostatin
SYT1 synaptotagmin I
TCF4 transcription factor 4
TMEM176B transmembrane protein 176B
TRIB3 tribbles pseudokinase 3
USP6NL USP6 N-terminal like
WFDC2 WAP four-disulfide core domain 2
WFS1 Wolfram syndrome 1 (wolframin)