BRD-K69840642_HDAC6 inhibitor ISOX_WSUDLCL2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

195 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_WSUDLCL2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADAM9 ADAM metallopeptidase domain 9
AKAP12 A kinase (PRKA) anchor protein 12
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALDOC aldolase C, fructose-bisphosphate
ARHGAP29 Rho GTPase activating protein 29
ARMCX2 armadillo repeat containing, X-linked 2
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BST2 bone marrow stromal cell antigen 2
C3ORF14 chromosome 3 open reading frame 14
CA2 carbonic anhydrase II
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CES2 carboxylesterase 2
CFI complement factor I
CLC Charcot-Leyden crystal galectin
COPG1 coatomer protein complex, subunit gamma 1
CRIP2 cysteine-rich protein 2
CYLD cylindromatosis (turban tumor syndrome)
DDAH1 dimethylarginine dimethylaminohydrolase 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DSTN destrin (actin depolymerizing factor)
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EMP2 epithelial membrane protein 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ESYT1 extended synaptotagmin-like protein 1
FASTKD5 FAST kinase domains 5
FNBP1L formin binding protein 1-like
G6PD glucose-6-phosphate dehydrogenase
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GOLM1 golgi membrane protein 1
HIST1H1C histone cluster 1, H1c
HN1 hematological and neurological expressed 1
HPSE heparanase
HSPA1A heat shock 70kDa protein 1A
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
JUND jun D proto-oncogene
KDM5A lysine (K)-specific demethylase 5A
L1CAM L1 cell adhesion molecule
LRP4 low density lipoprotein receptor-related protein 4
LRRN3 leucine rich repeat neuronal 3
MAB21L2 mab-21-like 2 (C. elegans)
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MGP matrix Gla protein
MPPED2 metallophosphoesterase domain containing 2
MT1E metallothionein 1E
MT1H metallothionein 1H
MT1X metallothionein 1X
MT2A metallothionein 2A
MTMR11 myotubularin related protein 11
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
NCAM1 neural cell adhesion molecule 1
NDFIP1 Nedd4 family interacting protein 1
NFIB nuclear factor I/B
NOSIP nitric oxide synthase interacting protein
NPTX2 neuronal pentraxin II
NR4A2 nuclear receptor subfamily 4, group A, member 2
NSFL1C NSFL1 (p97) cofactor (p47)
PCLO piccolo presynaptic cytomatrix protein
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PKM pyruvate kinase, muscle
PLA2G15 phospholipase A2, group XV
PLAT plasminogen activator, tissue
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLD3 phospholipase D family, member 3
POLB polymerase (DNA directed), beta
PRAME preferentially expressed antigen in melanoma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCA protein kinase C, alpha
PRKCI protein kinase C, iota
PRSS2 protease, serine, 2 (trypsin 2)
PTN pleiotrophin
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RBKS ribokinase
RGS2 regulator of G-protein signaling 2
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RTN2 reticulon 2
SCGB2A2 secretoglobin, family 2A, member 2
SCML1 sex comb on midleg-like 1 (Drosophila)
SFTPB surfactant protein B
SLC16A4 solute carrier family 16, member 4
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SRGN serglycin
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TKTL1 transketolase-like 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
ZCCHC24 zinc finger, CCHC domain containing 24

decreased expression

Symbol Name
ADA adenosine deaminase
ADAM12 ADAM metallopeptidase domain 12
ADM adrenomedullin
AEBP1 AE binding protein 1
AHNAK2 AHNAK nucleoprotein 2
ALCAM activated leukocyte cell adhesion molecule
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
APOA2 apolipoprotein A-II
APOD apolipoprotein D
ATF5 activating transcription factor 5
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL2 B-cell CLL/lymphoma 2
BDH1 3-hydroxybutyrate dehydrogenase, type 1
CCL19 chemokine (C-C motif) ligand 19
CD48 CD48 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CKAP4 cytoskeleton-associated protein 4
CLIC4 chloride intracellular channel 4
CLU clusterin
COCH cochlin
COL4A6 collagen, type IV, alpha 6
CTPS1 CTP synthase 1
CYB5R2 cytochrome b5 reductase 2
CYBA cytochrome b-245, alpha polypeptide
DCLK1 doublecortin-like kinase 1
DCN decorin
DHRS7 dehydrogenase/reductase (SDR family) member 7
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DUSP6 dual specificity phosphatase 6
ELOVL6 ELOVL fatty acid elongase 6
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
GAS1 growth arrest-specific 1
GPX2 glutathione peroxidase 2
GSTO1 glutathione S-transferase omega 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IRAK1 interleukin-1 receptor-associated kinase 1
KEAP1 kelch-like ECH-associated protein 1
KLF4 Kruppel-like factor 4 (gut)
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LRMP lymphoid-restricted membrane protein
LTF lactotransferrin
LUM lumican
LYPLA1 lysophospholipase I
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP7 microtubule-associated protein 7
MFAP5 microfibrillar associated protein 5
MICALL1 MICAL-like 1
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MSMB microseminoprotein, beta-
MXRA5 matrix-remodelling associated 5
MYC v-myc avian myelocytomatosis viral oncogene homolog
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PAX5 paired box 5
PDGFRL platelet-derived growth factor receptor-like
PERP PERP, TP53 apoptosis effector
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
POU2AF1 POU class 2 associating factor 1
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PTK2 protein tyrosine kinase 2
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRC protein tyrosine phosphatase, receptor type, C
PXDN peroxidasin
QPRT quinolinate phosphoribosyltransferase
RCN1 reticulocalbin 1, EF-hand calcium binding domain
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SIK1 salt-inducible kinase 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC35F2 solute carrier family 35, member F2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SPON2 spondin 2, extracellular matrix protein
SPRY2 sprouty homolog 2 (Drosophila)
STAP1 signal transducing adaptor family member 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TCF12 transcription factor 12
TMEM123 transmembrane protein 123
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TRAF1 TNF receptor-associated factor 1
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UPK1B uroplakin 1B
VPREB3 pre-B lymphocyte 3
WIPF1 WAS/WASL interacting protein family, member 1
XPO7 exportin 7