BRD-K69840642_HDAC6 inhibitor ISOX_THP1_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

295 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_THP1_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ADD3 adducin 3 (gamma)
ADRB2 adrenoceptor beta 2, surface
ANKRD46 ankyrin repeat domain 46
APP amyloid beta (A4) precursor protein
ARHGAP29 Rho GTPase activating protein 29
ARL3 ADP-ribosylation factor-like 3
ARMCX2 armadillo repeat containing, X-linked 2
ASMTL acetylserotonin O-methyltransferase-like
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BBX bobby sox homolog (Drosophila)
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG2 BTG family, member 2
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CCL4 chemokine (C-C motif) ligand 4
CCNG2 cyclin G2
CD24 CD24 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD47 CD47 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CETN2 centrin, EF-hand protein, 2
CGA glycoprotein hormones, alpha polypeptide
CGRRF1 cell growth regulator with ring finger domain 1
CLDN10 claudin 10
CLDN3 claudin 3
CLIC4 chloride intracellular channel 4
CORO1C coronin, actin binding protein, 1C
CPNE3 copine III
CREM cAMP responsive element modulator
CSRP1 cysteine and glycine-rich protein 1
DCTN3 dynactin 3 (p22)
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24
DHCR7 7-dehydrocholesterol reductase
DLX2 distal-less homeobox 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DPYSL2 dihydropyrimidinase-like 2
DSTN destrin (actin depolymerizing factor)
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
ECHDC3 enoyl CoA hydratase domain containing 3
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFHD1 EF-hand domain family, member D1
EGR1 early growth response 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EZR ezrin
FCGBP Fc fragment of IgG binding protein
FCHO1 FCH domain only 1
FHL1 four and a half LIM domains 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
G6PD glucose-6-phosphate dehydrogenase
GADD45B growth arrest and DNA-damage-inducible, beta
GCH1 GTP cyclohydrolase 1
GLRX glutaredoxin (thioltransferase)
GM2A GM2 ganglioside activator
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GPX3 glutathione peroxidase 3
GREM1 gremlin 1, DAN family BMP antagonist
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HK1 hexokinase 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDI1 isopentenyl-diphosphate delta isomerase 1
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFI30 interferon, gamma-inducible protein 30
IFI6 interferon, alpha-inducible protein 6
IFT57 intraflagellar transport 57
IGFBP5 insulin-like growth factor binding protein 5
IL17RB interleukin 17 receptor B
IL1B interleukin 1, beta
INSIG1 insulin induced gene 1
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
JUN jun proto-oncogene
KCTD12 potassium channel tetramerization domain containing 12
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIMA1 LIM domain and actin binding 1
LPIN1 lipin 1
MAP7 microtubule-associated protein 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MKNK1 MAP kinase interacting serine/threonine kinase 1
MLF1 myeloid leukemia factor 1
MPZL1 myelin protein zero-like 1
MSMO1 methylsterol monooxygenase 1
MTUS1 microtubule associated tumor suppressor 1
MYO6 myosin VI
NEU1 sialidase 1 (lysosomal sialidase)
NIT1 nitrilase 1
NME7 NME/NM23 family member 7
NPC1 Niemann-Pick disease, type C1
NPTX2 neuronal pentraxin II
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NSDHL NAD(P) dependent steroid dehydrogenase-like
NXN nucleoredoxin
PALLD palladin, cytoskeletal associated protein
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PEG10 paternally expressed 10
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHKG2 phosphorylase kinase, gamma 2 (testis)
PLA2G15 phospholipase A2, group XV
PLA2G16 phospholipase A2, group XVI
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLD3 phospholipase D family, member 3
PLS1 plastin 1
PNMA2 paraneoplastic Ma antigen 2
POLB polymerase (DNA directed), beta
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PROM1 prominin 1
PROSC proline synthetase co-transcribed homolog (bacterial)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PXDN peroxidasin
QPCT glutaminyl-peptide cyclotransferase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RABAC1 Rab acceptor 1 (prenylated)
RAP2A RAP2A, member of RAS oncogene family
RGS2 regulator of G-protein signaling 2
RRAGC Ras-related GTP binding C
RRBP1 ribosome binding protein 1
RTN2 reticulon 2
RYBP RING1 and YY1 binding protein
SAMD4A sterile alpha motif domain containing 4A
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A2 secretoglobin, family 2A, member 2
SCPEP1 serine carboxypeptidase 1
SDC4 syndecan 4
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SESN1 sestrin 1
SIK1 salt-inducible kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
SOX9 SRY (sex determining region Y)-box 9
SPAG9 sperm associated antigen 9
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPON1 spondin 1, extracellular matrix protein
SQLE squalene epoxidase
SST somatostatin
STX1A syntaxin 1A (brain)
STXBP1 syntaxin binding protein 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYNM synemin, intermediate filament protein
TFF1 trefoil factor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM41B transmembrane protein 41B
TOB1 transducer of ERBB2, 1
TPD52 tumor protein D52
TPD52L1 tumor protein D52-like 1
TPMT thiopurine S-methyltransferase
TSPAN13 tetraspanin 13
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
UGCG UDP-glucose ceramide glucosyltransferase
UNC13B unc-13 homolog B (C. elegans)
USP6NL USP6 N-terminal like
VCL vinculin
WIPI1 WD repeat domain, phosphoinositide interacting 1
WLS wntless Wnt ligand secretion mediator
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
ADI1 acireductone dioxygenase 1
ADNP activity-dependent neuroprotector homeobox
AKAP8 A kinase (PRKA) anchor protein 8
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANPEP alanyl (membrane) aminopeptidase
ARID1A AT rich interactive domain 1A (SWI-like)
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
AZU1 azurocidin 1
BCL2 B-cell CLL/lymphoma 2
BCLAF1 BCL2-associated transcription factor 1
BEX1 brain expressed, X-linked 1
C6ORF62 chromosome 6 open reading frame 62
CARKD carbohydrate kinase domain containing
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CD36 CD36 molecule (thrombospondin receptor)
CD58 CD58 molecule
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CES1 carboxylesterase 1
CLEC11A C-type lectin domain family 11, member A
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
COCH cochlin
CREBZF CREB/ATF bZIP transcription factor
CSK c-src tyrosine kinase
CSTA cystatin A (stefin A)
CTPS1 CTP synthase 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYC1 cytochrome c-1
DCTD dCMP deaminase
DKK1 dickkopf WNT signaling pathway inhibitor 1
ELANE elastase, neutrophil expressed
ELF1 E74-like factor 1 (ets domain transcription factor)
FAM60A family with sequence similarity 60, member A
FKBP11 FK506 binding protein 11, 19 kDa
GATAD1 GATA zinc finger domain containing 1
GBE1 glucan (1,4-alpha-), branching enzyme 1
GSAP gamma-secretase activating protein
GSTO1 glutathione S-transferase omega 1
GUSBP3 glucuronidase, beta pseudogene 3
HAL histidine ammonia-lyase
HDGF hepatoma-derived growth factor
HMGB2 high mobility group box 2
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HOMER3 homer scaffolding protein 3
IL6R interleukin 6 receptor
IL7R interleukin 7 receptor
IRAK1 interleukin-1 receptor-associated kinase 1
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
KRT6A keratin 6A, type II
LINC00341 long intergenic non-protein coding RNA 341
LPL lipoprotein lipase
LYZ lysozyme
MEPCE methylphosphate capping enzyme
MKI67 marker of proliferation Ki-67
MSL1 male-specific lethal 1 homolog (Drosophila)
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO1F myosin IF
N4BP2L2 NEDD4 binding protein 2-like 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NID1 nidogen 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUP62 nucleoporin 62kDa
OBSL1 obscurin-like 1
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PHF2 PHD finger protein 2
PLK1 polo-like kinase 1
PON2 paraoxonase 2
PTBP1 polypyrimidine tract binding protein 1
PTPN6 protein tyrosine phosphatase, non-receptor type 6
QKI QKI, KH domain containing, RNA binding
RAD23B RAD23 homolog B (S. cerevisiae)
RBM3 RNA binding motif (RNP1, RRM) protein 3
RBMX RNA binding motif protein, X-linked
RCN1 reticulocalbin 1, EF-hand calcium binding domain
REPIN1 replication initiator 1
RPL31 ribosomal protein L31
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMYD2 SET and MYND domain containing 2
SNRPE small nuclear ribonucleoprotein polypeptide E
SPAG7 sperm associated antigen 7
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SRSF8 serine/arginine-rich splicing factor 8
STAG2 stromal antigen 2
STEAP3 STEAP family member 3, metalloreductase
SUN2 Sad1 and UNC84 domain containing 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCF3 transcription factor 3
TGOLN2 trans-golgi network protein 2
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TLK2 tousled-like kinase 2
TNS3 tensin 3
TRIM13 tripartite motif containing 13
TRIP6 thyroid hormone receptor interactor 6
UBE2C ubiquitin-conjugating enzyme E2C
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UFC1 ubiquitin-fold modifier conjugating enzyme 1
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
USP34 ubiquitin specific peptidase 34
XPOT exportin, tRNA
ZDHHC6 zinc finger, DHHC-type containing 6
ZHX2 zinc fingers and homeoboxes 2
ZNF274 zinc finger protein 274
ZNF430 zinc finger protein 430
ZNF551 zinc finger protein 551
ZNF586 zinc finger protein 586
ZNF91 zinc finger protein 91