BRD-K69840642_HDAC6 inhibitor ISOX_SW948_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

181 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_SW948_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ACOT7 acyl-CoA thioesterase 7
ADD3 adducin 3 (gamma)
ALB albumin
ALDOB aldolase B, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ARL3 ADP-ribosylation factor-like 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C14ORF132 chromosome 14 open reading frame 132
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCDC92 coiled-coil domain containing 92
CCNG2 cyclin G2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL6A3 collagen, type VI, alpha 3
CTSK cathepsin K
CXCL9 chemokine (C-X-C motif) ligand 9
CYFIP2 cytoplasmic FMR1 interacting protein 2
DCN decorin
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
ENAH enabled homolog (Drosophila)
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FAM107A family with sequence similarity 107, member A
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GLRX glutaredoxin (thioltransferase)
GPNMB glycoprotein (transmembrane) nmb
GSTM3 glutathione S-transferase mu 3 (brain)
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HLTF helicase-like transcription factor
HSPA2 heat shock 70kDa protein 2
IDI1 isopentenyl-diphosphate delta isomerase 1
IER3 immediate early response 3
IGFBP5 insulin-like growth factor binding protein 5
ITM2A integral membrane protein 2A
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
L1CAM L1 cell adhesion molecule
MAOB monoamine oxidase B
MAP1A microtubule-associated protein 1A
MICB MHC class I polypeptide-related sequence B
MLF1 myeloid leukemia factor 1
MMP9 matrix metallopeptidase 9
MT1X metallothionein 1X
MXI1 MAX interactor 1, dimerization protein
NBPF10 neuroblastoma breakpoint family, member 10
NOSIP nitric oxide synthase interacting protein
OAT ornithine aminotransferase
OLFM1 olfactomedin 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDE8B phosphodiesterase 8B
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHYH phytanoyl-CoA 2-hydroxylase
PLA2G15 phospholipase A2, group XV
PLAU plasminogen activator, urokinase
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PRAF2 PRA1 domain family, member 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAP1GAP RAP1 GTPase activating protein
RGS10 regulator of G-protein signaling 10
RGS2 regulator of G-protein signaling 2
RIMS3 regulating synaptic membrane exocytosis 3
RNASE6 ribonuclease, RNase A family, k6
SCPEP1 serine carboxypeptidase 1
SGK1 serum/glucocorticoid regulated kinase 1
SGPP1 sphingosine-1-phosphate phosphatase 1
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SMYD3 SET and MYND domain containing 3
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRPX sushi-repeat containing protein, X-linked
STC1 stanniocalcin 1
STXBP1 syntaxin binding protein 1
SULF1 sulfatase 1
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
THBS2 thrombospondin 2
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TKTL1 transketolase-like 1
TRAK2 trafficking protein, kinesin binding 2
TSPAN7 tetraspanin 7
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
VIM vimentin
VWA5A von Willebrand factor A domain containing 5A
YPEL5 yippee-like 5 (Drosophila)
ZBTB16 zinc finger and BTB domain containing 16

decreased expression

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BMP4 bone morphogenetic protein 4
C8ORF4 chromosome 8 open reading frame 4
CCL2 chemokine (C-C motif) ligand 2
CCNB2 cyclin B2
CCND2 cyclin D2
CDC25A cell division cycle 25A
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CIAPIN1 cytokine induced apoptosis inhibitor 1
CSK c-src tyrosine kinase
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DSG2 desmoglein 2
DUSP4 dual specificity phosphatase 4
EGFR epidermal growth factor receptor
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM57A family with sequence similarity 57, member A
FAM60A family with sequence similarity 60, member A
FHL2 four and a half LIM domains 2
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GABPB1 GA binding protein transcription factor, beta subunit 1
GANAB glucosidase, alpha; neutral AB
GPX1 glutathione peroxidase 1
GPX2 glutathione peroxidase 2
HMGA2 high mobility group AT-hook 2
HOXA10 homeobox A10
IL1RN interleukin 1 receptor antagonist
ITGA6 integrin, alpha 6
KANK1 KN motif and ankyrin repeat domains 1
KCNK1 potassium channel, two pore domain subfamily K, member 1
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
KLF5 Kruppel-like factor 5 (intestinal)
LCN2 lipocalin 2
LMNB1 lamin B1
MANSC1 MANSC domain containing 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MDK midkine (neurite growth-promoting factor 2)
MEPCE methylphosphate capping enzyme
MET MET proto-oncogene, receptor tyrosine kinase
MGST2 microsomal glutathione S-transferase 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO5C myosin VC
NMI N-myc (and STAT) interactor
NRIP1 nuclear receptor interacting protein 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLBD1 phospholipase B domain containing 1
PLK1 polo-like kinase 1
PON2 paraoxonase 2
PPIF peptidylprolyl isomerase F
PROM1 prominin 1
PUF60 poly-U binding splicing factor 60KDa
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SLC35F2 solute carrier family 35, member F2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SORBS3 sorbin and SH3 domain containing 3
SPATS2L spermatogenesis associated, serine-rich 2-like
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYPL1 synaptophysin-like 1
TACSTD2 tumor-associated calcium signal transducer 2
TEAD4 TEA domain family member 4
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TLK1 tousled-like kinase 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TRAK1 trafficking protein, kinesin binding 1
TRIM14 tripartite motif containing 14
TRIM16 tripartite motif containing 16
TRIM29 tripartite motif containing 29
TSPAN8 tetraspanin 8
WDR82 WD repeat domain 82
ZBED1 zinc finger, BED-type containing 1
ZFP36L2 ZFP36 ring finger protein-like 2