BRD-K69840642_HDAC6 inhibitor ISOX_SW480_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

159 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_SW480_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABAT 4-aminobutyrate aminotransferase
AMIGO2 adhesion molecule with Ig-like domain 2
ANPEP alanyl (membrane) aminopeptidase
APP amyloid beta (A4) precursor protein
ASRGL1 asparaginase like 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
CALB1 calbindin 1, 28kDa
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCNA1 cyclin A1
CD200 CD200 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CDC25B cell division cycle 25B
CLIC4 chloride intracellular channel 4
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CORO1A coronin, actin binding protein, 1A
CPE carboxypeptidase E
CREB1 cAMP responsive element binding protein 1
CTSZ cathepsin Z
CYBB cytochrome b-245, beta polypeptide
DCHS1 dachsous cadherin-related 1
DPYD dihydropyrimidine dehydrogenase
DPYSL2 dihydropyrimidinase-like 2
DPYSL3 dihydropyrimidinase-like 3
EIF5A eukaryotic translation initiation factor 5A
FADS3 fatty acid desaturase 3
FN1 fibronectin 1
GFOD1 glucose-fructose oxidoreductase domain containing 1
H1F0 H1 histone family, member 0
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HNMT histamine N-methyltransferase
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFNGR1 interferon gamma receptor 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IL1R1 interleukin 1 receptor, type I
JUN jun proto-oncogene
LGALS1 lectin, galactoside-binding, soluble, 1
LOC100505650 uncharacterized LOC100505650
MFAP5 microfibrillar associated protein 5
NEFH neurofilament, heavy polypeptide
NNMT nicotinamide N-methyltransferase
PCDH9 protocadherin 9
PCP4 Purkinje cell protein 4
PDE8B phosphodiesterase 8B
PEG10 paternally expressed 10
PELI1 pellino E3 ubiquitin protein ligase 1
PENK proenkephalin
PLA2G15 phospholipase A2, group XV
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PXDN peroxidasin
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RAP1GAP RAP1 GTPase activating protein
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
SCGB1D2 secretoglobin, family 1D, member 2
SELE selectin E
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SNN stannin
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRGN serglycin
SSBP2 single-stranded DNA binding protein 2
SULF1 sulfatase 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP3 TIMP metallopeptidase inhibitor 3
TUBB2A tubulin, beta 2A class IIa
VNN1 vanin 1
ZNF91 zinc finger protein 91
ZW10 zw10 kinetochore protein

decreased expression

Symbol Name
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
AMPD3 adenosine monophosphate deaminase 3
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANO1 anoctamin 1, calcium activated chloride channel
AQP3 aquaporin 3 (Gill blood group)
BAG2 BCL2-associated athanogene 2
BHLHE40 basic helix-loop-helix family, member e40
BMP2 bone morphogenetic protein 2
BMP4 bone morphogenetic protein 4
CA12 carbonic anhydrase XII
CXCL8 chemokine (C-X-C motif) ligand 8
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPN2 epsin 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM134B family with sequence similarity 134, member B
FAM57A family with sequence similarity 57, member A
FGFR3 fibroblast growth factor receptor 3
FKBP11 FK506 binding protein 11, 19 kDa
FOXG1 forkhead box G1
GATAD1 GATA zinc finger domain containing 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GOLGA8H golgin A8 family, member H
GPNMB glycoprotein (transmembrane) nmb
GPX2 glutathione peroxidase 2
GRWD1 glutamate-rich WD repeat containing 1
GSAP gamma-secretase activating protein
GSTO1 glutathione S-transferase omega 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGF1R insulin-like growth factor 1 receptor
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
KCNK1 potassium channel, two pore domain subfamily K, member 1
KEAP1 kelch-like ECH-associated protein 1
KIAA0101 KIAA0101
LAPTM4B lysosomal protein transmembrane 4 beta
LY6D lymphocyte antigen 6 complex, locus D
MCM5 minichromosome maintenance complex component 5
MDK midkine (neurite growth-promoting factor 2)
METTL7A methyltransferase like 7A
MGP matrix Gla protein
MLH3 mutL homolog 3
MRPS2 mitochondrial ribosomal protein S2
NRN1 neuritin 1
NUP62 nucleoporin 62kDa
PCNA proliferating cell nuclear antigen
PCSK6 proprotein convertase subtilisin/kexin type 6
PDLIM4 PDZ and LIM domain 4
PFKP phosphofructokinase, platelet
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PIR pirin (iron-binding nuclear protein)
PLAGL1 pleiomorphic adenoma gene-like 1
POU2AF1 POU class 2 associating factor 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRDX4 peroxiredoxin 4
PROM1 prominin 1
PRPS2 phosphoribosyl pyrophosphate synthetase 2
RBM26 RNA binding motif protein 26
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RNF167 ring finger protein 167
RPL27A ribosomal protein L27a
RPS11 ribosomal protein S11
SALL1 spalt-like transcription factor 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC35F2 solute carrier family 35, member F2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SMYD2 SET and MYND domain containing 2
SOX4 SRY (sex determining region Y)-box 4
SPRR1A small proline-rich protein 1A
SPRY2 sprouty homolog 2 (Drosophila)
STX1A syntaxin 1A (brain)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFF1 trefoil factor 1
TLK1 tousled-like kinase 1
TM4SF1 transmembrane 4 L six family member 1
TMEM109 transmembrane protein 109
TSC22D1 TSC22 domain family, member 1
TSKU tsukushi, small leucine rich proteoglycan
TSPAN8 tetraspanin 8
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
WEE1 WEE1 G2 checkpoint kinase