BRD-K69840642_HDAC6 inhibitor ISOX_SNUC5_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

194 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_SNUC5_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACAA1 acetyl-CoA acyltransferase 1
ADCY9 adenylate cyclase 9
ADD3 adducin 3 (gamma)
ALDOC aldolase C, fructose-bisphosphate
ARHGAP29 Rho GTPase activating protein 29
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BSG basigin (Ok blood group)
BZW2 basic leucine zipper and W2 domains 2
C14ORF132 chromosome 14 open reading frame 132
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CORO1A coronin, actin binding protein, 1A
CSRP1 cysteine and glycine-rich protein 1
DCTN3 dynactin 3 (p22)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPYSL2 dihydropyrimidinase-like 2
DSTN destrin (actin depolymerizing factor)
EAF2 ELL associated factor 2
FERMT2 fermitin family member 2
FN1 fibronectin 1
GADD45B growth arrest and DNA-damage-inducible, beta
GLRX glutaredoxin (thioltransferase)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GRN granulin
GSN gelsolin
H1F0 H1 histone family, member 0
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HMOX1 heme oxygenase 1
HN1 hematological and neurological expressed 1
HSPB1 heat shock 27kDa protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IGSF3 immunoglobulin superfamily, member 3
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KCTD5 potassium channel tetramerization domain containing 5
LPCAT1 lysophosphatidylcholine acyltransferase 1
MAPT microtubule-associated protein tau
MBNL2 muscleblind-like splicing regulator 2
MCOLN1 mucolipin 1
MFAP4 microfibrillar-associated protein 4
MSRB1 methionine sulfoxide reductase B1
MT1E metallothionein 1E
MT1G metallothionein 1G
MT1HL1 metallothionein 1H-like 1
MTUS1 microtubule associated tumor suppressor 1
MYH10 myosin, heavy chain 10, non-muscle
NDRG1 N-myc downstream regulated 1
NOSIP nitric oxide synthase interacting protein
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PALLD palladin, cytoskeletal associated protein
PLA2G15 phospholipase A2, group XV
PLAT plasminogen activator, tissue
PLIN3 perilipin 3
PMP22 peripheral myelin protein 22
PNMA2 paraneoplastic Ma antigen 2
PRDX1 peroxiredoxin 1
PRDX2 peroxiredoxin 2
PRSS3 protease, serine, 3
PRSS8 protease, serine, 8
PTTG1IP pituitary tumor-transforming 1 interacting protein
PXMP2 peroxisomal membrane protein 2, 22kDa
RAD9A RAD9 homolog A (S. pombe)
RAP1GAP RAP1 GTPase activating protein
RIOK3 RIO kinase 3
RND1 Rho family GTPase 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
S100A14 S100 calcium binding protein A14
SCPEP1 serine carboxypeptidase 1
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SEPT6 septin 6
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SKP1 S-phase kinase-associated protein 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SPAG9 sperm associated antigen 9
SRGN serglycin
SRPX sushi-repeat containing protein, X-linked
STK17A serine/threonine kinase 17a
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
STXBP1 syntaxin binding protein 1
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TBPL1 TBP-like 1
TICAM1 toll-like receptor adaptor molecule 1
TLE4 transducin-like enhancer of split 4
TRAK2 trafficking protein, kinesin binding 2
TSPAN13 tetraspanin 13
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
VAT1 vesicle amine transport 1
WDTC1 WD and tetratricopeptide repeats 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADAM12 ADAM metallopeptidase domain 12
ALCAM activated leukocyte cell adhesion molecule
ATF5 activating transcription factor 5
BEX1 brain expressed, X-linked 1
BHLHE41 basic helix-loop-helix family, member e41
C6ORF62 chromosome 6 open reading frame 62
CCDC86 coiled-coil domain containing 86
CCNB2 cyclin B2
CCND2 cyclin D2
CDK14 cyclin-dependent kinase 14
CFLAR CASP8 and FADD-like apoptosis regulator
COL11A1 collagen, type XI, alpha 1
CTSO cathepsin O
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTIP cytohesin 1 interacting protein
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEPTOR DEP domain containing MTOR-interacting protein
DUT deoxyuridine triphosphatase
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EPCAM epithelial cell adhesion molecule
F5 coagulation factor V (proaccelerin, labile factor)
FAM60A family with sequence similarity 60, member A
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FOXE1 forkhead box E1
GATAD1 GATA zinc finger domain containing 1
GBE1 glucan (1,4-alpha-), branching enzyme 1
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPX2 glutathione peroxidase 2
GSAP gamma-secretase activating protein
HIST1H2BG histone cluster 1, H2bg
HMGA2 high mobility group AT-hook 2
HMGB2 high mobility group box 2
HOXA10 homeobox A10
HOXC10 homeobox C10
IDO1 indoleamine 2,3-dioxygenase 1
IL1R2 interleukin 1 receptor, type II
IRAK1 interleukin-1 receptor-associated kinase 1
IRS1 insulin receptor substrate 1
JADE2 jade family PHD finger 2
KDM5D lysine (K)-specific demethylase 5D
KHNYN KH and NYN domain containing
KIAA0101 KIAA0101
KIAA0368 KIAA0368
KYNU kynureninase
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LOX lysyl oxidase
LTF lactotransferrin
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK13 mitogen-activated protein kinase 13
MCTP1 multiple C2 domains, transmembrane 1
MECOM MDS1 and EVI1 complex locus
MMP9 matrix metallopeptidase 9
NARFL nuclear prelamin A recognition factor-like
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NMI N-myc (and STAT) interactor
NR2F6 nuclear receptor subfamily 2, group F, member 6
NT5E 5'-nucleotidase, ecto (CD73)
NUSAP1 nucleolar and spindle associated protein 1
OBSL1 obscurin-like 1
PDGFC platelet derived growth factor C
PGLS 6-phosphogluconolactonase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PON2 paraoxonase 2
PRRX1 paired related homeobox 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGCC regulator of cell cycle
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPP38 ribonuclease P/MRP 38kDa subunit
RRM2 ribonucleotide reductase M2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SFRP4 secreted frizzled-related protein 4
SLC35F2 solute carrier family 35, member F2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
STEAP1 six transmembrane epithelial antigen of the prostate 1
SULF1 sulfatase 1
TRIM22 tripartite motif containing 22
TSPYL5 TSPY-like 5
TYMS thymidylate synthetase
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
YBX3 Y box binding protein 3
ZHX2 zinc fingers and homeoboxes 2
ZSCAN31 zinc finger and SCAN domain containing 31