BRD-K69840642_HDAC6 inhibitor ISOX_SNUC4_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

157 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_SNUC4_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDOC aldolase C, fructose-bisphosphate
ANXA6 annexin A6
AOX1 aldehyde oxidase 1
AP2B1 adaptor-related protein complex 2, beta 1 subunit
ARHGAP29 Rho GTPase activating protein 29
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C9ORF16 chromosome 9 open reading frame 16
CALCOCO2 calcium binding and coiled-coil domain 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHGA chromogranin A
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN10 claudin 10
COL15A1 collagen, type XV, alpha 1
CYLD cylindromatosis (turban tumor syndrome)
DCTN3 dynactin 3 (p22)
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DEPTOR DEP domain containing MTOR-interacting protein
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
EFHD1 EF-hand domain family, member D1
ELF5 E74-like factor 5 (ets domain transcription factor)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
G0S2 G0/G1 switch 2
GADD45B growth arrest and DNA-damage-inducible, beta
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLRX glutaredoxin (thioltransferase)
GPC3 glypican 3
H1F0 H1 histone family, member 0
HOXC6 homeobox C6
IFT57 intraflagellar transport 57
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGKV1-5 immunoglobulin kappa variable 1-5
JUN jun proto-oncogene
KCTD12 potassium channel tetramerization domain containing 12
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS2 lectin, galactoside-binding, soluble, 2
LIMA1 LIM domain and actin binding 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MLF1 myeloid leukemia factor 1
NOSIP nitric oxide synthase interacting protein
NPTX2 neuronal pentraxin II
NRGN neurogranin (protein kinase C substrate, RC3)
NT5E 5'-nucleotidase, ecto (CD73)
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PCSK5 proprotein convertase subtilisin/kexin type 5
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PLA2G15 phospholipase A2, group XV
PLAU plasminogen activator, urokinase
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RAB3B RAB3B, member RAS oncogene family
RAB5C RAB5C, member RAS oncogene family
RGS2 regulator of G-protein signaling 2
RGS4 regulator of G-protein signaling 4
RNF167 ring finger protein 167
ROGDI rogdi homolog (Drosophila)
RTN3 reticulon 3
SCGB1D2 secretoglobin, family 1D, member 2
SCPEP1 serine carboxypeptidase 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGK1 serum/glucocorticoid regulated kinase 1
SRPX sushi-repeat containing protein, X-linked
SST somatostatin
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STX1A syntaxin 1A (brain)
STXBP1 syntaxin binding protein 1
TBPL1 TBP-like 1
THBS2 thrombospondin 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNS1 tensin 1
TSPAN7 tetraspanin 7
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
TXNIP thioredoxin interacting protein
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UGCG UDP-glucose ceramide glucosyltransferase
VCAN versican
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ADORA2B adenosine A2b receptor
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANXA3 annexin A3
AQP3 aquaporin 3 (Gill blood group)
ATF5 activating transcription factor 5
AUTS2 autism susceptibility candidate 2
BASP1 brain abundant, membrane attached signal protein 1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C1ORF116 chromosome 1 open reading frame 116
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCND1 cyclin D1
CCND2 cyclin D2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CFLAR CASP8 and FADD-like apoptosis regulator
CST7 cystatin F (leukocystatin)
CTPS1 CTP synthase 1
CXCL3 chemokine (C-X-C motif) ligand 3
CYC1 cytochrome c-1
CYCS cytochrome c, somatic
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DACH1 dachshund family transcription factor 1
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
FAM57A family with sequence similarity 57, member A
FAM60A family with sequence similarity 60, member A
FCGBP Fc fragment of IgG binding protein
FOSL1 FOS-like antigen 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GPX2 glutathione peroxidase 2
GSAP gamma-secretase activating protein
IFRD2 interferon-related developmental regulator 2
IL1R2 interleukin 1 receptor, type II
IRAK1 interleukin-1 receptor-associated kinase 1
KEAP1 kelch-like ECH-associated protein 1
KRT13 keratin 13, type I
KRT15 keratin 15, type I
KRT6B keratin 6B, type II
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LYZ lysozyme
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEFH neurofilament, heavy polypeptide
PI3 peptidase inhibitor 3, skin-derived
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIR pirin (iron-binding nuclear protein)
PUF60 poly-U binding splicing factor 60KDa
RGS1 regulator of G-protein signaling 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
S100A8 S100 calcium binding protein A8
SATB1 SATB homeobox 1
SELENBP1 selenium binding protein 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC35F2 solute carrier family 35, member F2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SLPI secretory leukocyte peptidase inhibitor
SNRPE small nuclear ribonucleoprotein polypeptide E
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SPRR1A small proline-rich protein 1A
SPRY2 sprouty homolog 2 (Drosophila)
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STXBP2 syntaxin binding protein 2
TM4SF1 transmembrane 4 L six family member 1
TNS3 tensin 3
TP53 tumor protein p53
TRIM2 tripartite motif containing 2
TRIM29 tripartite motif containing 29
TSPAN8 tetraspanin 8
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon